Nutritional deficiencies in recurrent aphthae

Abstract

A series of 330 patients with recurrent aphthae was screened for deficiencies of iron, folate and vitamin B|2. In 47 patients (14.2 %) such deficiencies were found; 23 were deficient in iron, seven in folic acid, six in vitamin B|2 and in addition 11 patients had combined deficiencies.Clinical examination of the aphthae was not helpful in identifying individual patients with a nutritional deficiency although patients with an associated glossitis or angular cheilitis were more likely to suffer from such deficiencies.Screening of the patients by examination of their peripheral blood alone (estimation of haemoglobin and absolute values, and blood film examination) detected only a proportion of those with deficiencies of iron or folic acid, although in this series such screening was able to identify the small number of cases with vitamin B12 deficiency.The 39 patients with a proven nutritional deficiency who were available for follow-up showed a favourable response to corrective therapy; 23 showed a complete remission of ulcers, 11 were improved and five were not helped.The significance of these findings is discussed. It is suggested that the results indicate the need for lull haematological screening of all patients with recurrent aphthae.

Comparing the Effect of Injectable Vitamin B With Conventional Oral Treatment on Aphthous Stomatitis

“…In the research conducted by Olson et al (13), no significant difference was found between hematological parameters in patients with aphthous and healthy people, and these results were inconsistent with those of the current research, which examined these parameters in patients and healthy controls. Since some reports indicated that about 18% of patients with recurrent aphthous stomatitis are diagnosed with deficiencies in vitamin B12, folate, or iron, the hypothesized relationship between recurrent aphthous stomatitis and hematological disorders has been discussed (6,14). This suggests the importance of blood examination in diagnosis and treatment of patients.…”

“…The research conducted by Wary et al showed that topical treatments led to improvement until the treatment process continued (14), however, after the end, aphthous ulcers reappeared. Also, these treatments could not reduce the intervals and recurrence of the lesion.…”

The Prevalence of Recurrent Aphthous Stomatitis in Patients With Hematinic Deficiency

“…5,8,11,[15][16][17][18] Iron, vitamin B12 and folic acid deficiencies were reported as predisposing factors in RAS in several studies. 4,5,8,10,11,16,18 Porter et al 18 have determined the frequency of anaemia and/or HD in RAS. They indicated that 11.6% of RAS patients had low iron storage when compared with 4.9% of control subjects and also indicated that neither patients nor control subjects had anaemia.…”

“…[2][3][4][5][6][7] The role and prevalence of HD such as iron, folic acid and vitamin B12 deficiencies in the aetiopathogenesis of RAS are not well known and many conflicting results have been reported in the literature. 4,5,[7][8][9][10] Wray et al 8,11 reported increased incidence of HD in RAS patients and suggested haematological screening in such patients. While many researchers supported this relationship, 5,9-13 conflicting studies exist as well.…”

Análise da expressão gênica do FOXP3, MIP-3? e Interleucinas 2, 10 e 35 em pacientes com ulceração aftosa recorrente

“…O novo conhecimento que a biologia molecular tem trazido a este campo vem também nos ajudando a compreender os vários fatores modificadores do comportamento das UAR que foram sendo observados pelos clínicos ao longo da história das UAR (Ship, 1972;Stanley, 1972;Miller;Ship, 1977;Wray et al, 1978;Wray et al, 1981;Woo, Sonis, 1996;Shotts et al, 1999;Tuzun et al, 2000;Boulinguez et al, 2000;Casiglia, 2002;Scully et al, 2003;Natah et al, 2004;Scully, Felix, 2005;Scully, Porter, 2008;Tappuni et al, 2013). Barros et al (2010) propuseram um modelo para a explicação dos eventos imunológicos que culminam na lesão de UAR, este está baseado no desequilíbrio das respostas Th1/Th2, a disfunção da barreira epitelial causada por alterações na função da via do receptor TLR2 em conjunto com uma redução da tolerância imunológica.…”