Nutritional Effect of Nandrolone Decanoate in Predialysis Patients With Chronic Kidney Disease

Eiam‐Ong, Somchai; Buranaosot, Somphon; Eiam-Ong, Somchit; Wathanavaha, Arpar; Pansin, Pongsuk

doi:10.1053/j.jrn.2007.01.001

Cited by 26 publications

(8 citation statements)

References 30 publications

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“…The effect of anabolic steroids on striated muscle is well known: application causes increased lean body mass and muscle protein synthesis in man 11,15,17,18,42,43 . Nandrolone decanoate, a derivative of testosterone, is recommended and is used to counteract catabolic processes in patients with postmenopausal osteoporosis 44,45 , sequelae of kidney disease 46,47 , and muscle wasting in human immunodeficiency virus 48 . Although we believe that nandrolone decanoate will produce a similarly beneficial effect in humans as observed in our animal model, further research is needed to determine optimal dose-effect relationships and delivery methods.…”

mentioning

confidence: 99%

Anabolic Steroids Reduce Muscle Damage Caused by Rotator Cuff Tendon Release in an Experimental Study in Rabbits

Gerber

Meyer

Nuss

et al. 2011

Journal of Bone and Joint Surgery

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To our knowledge, this is the first documentation of partial prevention of important muscle alterations after retraction of the supraspinatus musculotendinous unit caused by tendon disruption. Nandrolone decanoate administration in the phase after tendon release prevented fatty infiltration of the supraspinatus muscle and reduced functional muscle impairment caused by myotendinous retraction in this rabbit rotator cuff model, but two of seven rabbits that received the drug developed infections. Background: Muscles of the rotator cuff undergo retraction, atrophy, and fatty infiltration after a chronic tear, and a rabbit

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mentioning

confidence: 99%

Anabolic Steroids Reduce Muscle Damage Caused by Rotator Cuff Tendon Release in an Experimental Study in Rabbits

Gerber

Meyer

Nuss

et al. 2011

Journal of Bone and Joint Surgery

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“…This is an additional advantage of nandrolone over EPO, which has also been supported by randomized controlled trials that address this and related outcomes [18, 19]. …”

Section: Discussionmentioning

confidence: 92%

Meta-Analysis of Randomized Controlled Trials on Androgens versus Erythropoietin for Anaemia of Chronic Kidney Disease: Implications for Developing Countries

Adamu

Ma'aji

Erwin

et al. 2012

International Journal of Nephrology

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Androgens which are relatively cheap were used in the treatment of anaemia in dialysis patients before the advent of Erythropoietin (EPO). However, there are concerns about their efficacy and side effects. Aims. To examine the efficacy and harms of androgens for the treatment of anaemia of chronic kidney disease (CKD) compared to EPO. Settings and Design. A systematic review and meta-analysis using an a priori protocol. Methods and Materials. We searched several databases for randomized controlled trials using the key terms anaemia, chronic kidney disease, and androgens, without language restrictions. We also searched reference lists of relevant articles. Statistical Analysis Used. Data was analyzed using Review manger 5 software. We summarized treatment effects as relative risks and mean differences, with 95% confidence intervals using a random-effect model. We tested for heterogeneity with Chi2 and the I2 statistics. Results. We identified four eligible trials involving 114 participants, majority (83.33%) of whom were males, mostly over 50 years of age. The pooled difference in mean haemoglobin between the nandrolone and EPO arms at the end of the trials was −0.11 (CI −0.80 to 0.58) which is not statistically significant. Conclusions. This meta-analysis revealed no difference between nandrolone and EPO for the treatment of anaemia of CKD in men over 50 years. Therefore, nandrolone can be used for the treatment of anaemia of CKD in this category of patients, in resource-limited countries. However, further studies are needed to determine the long-term safety of nandrolone in men over 50 years old, as well as its effectiveness and safety in females in general, and males less than 50 years of age.

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“…No randomised controlled trials of any anabolic steroid in horses for treatment of anaemia were found in a search of the biomedical literature. In man, increases in packed cell volume (PCV) and haemoglobin have been reported in patients on haemodialysis receiving nandrolone decanoate (Barton Pai et al 2002); however, other studies in predialysis patients have shown no changes in PCV after nadrolone administration (Eiam-Ong et al 2007). In human patients with chronic obstructive pulmonary disease, increases in erythropoeitin and haemoglobin have been reported following nandrolone administration (Creutzberg et al 2003).…”

Section: Anabolic Steroids and Anaemiamentioning

confidence: 99%

An evidence‐based analysis of anabolic steroids as therapeutic agents in horses

Fajt

McCook

2008

Equine Veterinary Education

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Nutritional Effect of Nandrolone Decanoate in Predialysis Patients With Chronic Kidney Disease

Cited by 26 publications

References 30 publications

Anabolic Steroids Reduce Muscle Damage Caused by Rotator Cuff Tendon Release in an Experimental Study in Rabbits

Anabolic Steroids Reduce Muscle Damage Caused by Rotator Cuff Tendon Release in an Experimental Study in Rabbits

Meta-Analysis of Randomized Controlled Trials on Androgens versus Erythropoietin for Anaemia of Chronic Kidney Disease: Implications for Developing Countries

An evidence‐based analysis of anabolic steroids as therapeutic agents in horses

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