Nutritional Epigenomics and Age-Related Disease

Amenyah, Sophia; Ward, Mary; Strain, James J.; McNulty, Helene; Hughes, Catherine F; Dollin, Caitlin; Walsh, Colum P.; Lees-Murdock, Diane J.

doi:10.1093/cdn/nzaa097

Cited by 26 publications

(21 citation statements)

References 123 publications

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“…The epigenetic clock and nutritional epigenomics may contribute to aging as well as age-related diseases [ 4 ]. Thus, mapping food-related chemical profiles (diet) and molecular pathways is the main goal of the network-based “Foodome” project ( https://www.barabasilab.com/projects ).…”

Section: Epigenetics and Risk Stratification Of Cvds: Network Medicinmentioning

confidence: 99%

Clinical epigenetics settings for cancer and cardiovascular diseases: real-life applications of network medicine at the bedside

et al. 2021

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Despite impressive efforts invested in epigenetic research in the last 50 years, clinical applications are still lacking. Only a few university hospital centers currently use epigenetic biomarkers at the bedside. Moreover, the overall concept of precision medicine is not widely recognized in routine medical practice and the reductionist approach remains predominant in treating patients affected by major diseases such as cancer and cardiovascular diseases. By its’ very nature, epigenetics is integrative of genetic networks. The study of epigenetic biomarkers has led to the identification of numerous drugs with an increasingly significant role in clinical therapy especially of cancer patients. Here, we provide an overview of clinical epigenetics within the context of network analysis. We illustrate achievements to date and discuss how we can move from traditional medicine into the era of network medicine (NM), where pathway-informed molecular diagnostics will allow treatment selection following the paradigm of precision medicine.

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Section: Epigenetics and Risk Stratification Of Cvds: Network Medicinmentioning

confidence: 99%

Clinical epigenetics settings for cancer and cardiovascular diseases: real-life applications of network medicine at the bedside

et al. 2021

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“…A recent genome-wide DNA methylation study with 3096 participants demonstrated that tea and coffee consumption are also associated with altered methylation in two differentially methylated CpG sites (DNAJC16 and TTC17) [ 111 ]. Another study reported an association between ω-3 PUFA supplementation and vegetable and fruit consumption and lower GrimAgeAccel, DNAm PAI-1, DNAm ADM, and DNAm cystatin C which are considered epigenetic age markers enriched for DNA methylation sites that are surrogate biomarkers for blood plasma proteins related to aging [ 112 , 113 ].…”

Section: Effect Of Lifestyle and Environmental Factors On Epigenetic Modification In Older Adults With Cvdmentioning

confidence: 99%

“…Similarly, magnesium and selenium levels may function as potential epigenetic regulators via modulating different signaling pathways [ 112 , 113 , 122 ]. The possible epigenetic effects of selenium are the modulation of epigenetic information editors, interaction with miRNAs, as well as influence on the metabolism of a carbon, which acts as a methyl donor for DNA methylation [ 123 , 124 ].…”

Section: Effect Of Lifestyle and Environmental Factors On Epigenetic Modification In Older Adults With Cvdmentioning

confidence: 99%

How Are Epigenetic Modifications Related to Cardiovascular Disease in Older Adults?

Gharipour

Mani

Baghbahadorani

et al. 2021

IJMS

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The rate of aging has increased globally during recent decades and has led to a rising burden of age-related diseases such as cardiovascular disease (CVD). At the molecular level, epigenetic modifications have been shown recently to alter gene expression during the life course and impair cellular function. In this regard, several CVD risk factors, such as lifestyle and environmental factors, have emerged as key factors in epigenetic modifications within the cardiovascular system. In this study, we attempted to summarized recent evidence related to epigenetic modification, inflammation response, and CVD in older adults as well as the effect of lifestyle modification as a preventive strategy in this age group. Recent evidence showed that lifestyle and environmental factors may affect epigenetic mechanisms, such as DNA methylation, histone acetylation, and miRNA expression. Several substances or nutrients such as selenium, magnesium, curcumin, and caffeine (present in coffee and some teas) could regulate epigenetics. Similarly, physical inactivity, alcohol consumption, air pollutants, psychological stress, and shift working are well-known modifiers of epigenetic patterns. Understanding the exact ways that lifestyle and environmental factors could affect the expression of genes could help to influence the time of incidence and severity of aging-associated diseases. This review highlighted that a healthy lifestyle throughout the life course, such as a healthy diet rich in fibers, vitamins, and essential elements, and specific fatty acids, adequate physical activity and sleep, smoking cessation, and stress control, could be useful tools in preventing epigenetic changes that lead to impaired cardiovascular function.

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“…These modifications are mediated by DNA methyltransferases (DNMTs) which transfer a methyl group from S-adenosylmethionine (SAM) to the acceptor nucleotide. The epigenetic clock theory of aging has been proposed by identifying DNA methylation signatures able to predict biological age and disease susceptibility [160].…”

Section: Nutrients As Epigenetic Modulators Of Health Span and Longevitymentioning

confidence: 99%

Nutrients and Pathways that Regulate Health Span and Life Span

et al. 2020

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Both life span and health span are influenced by genetic, environmental and lifestyle factors. With the genetic influence on human life span estimated to be about 20–25%, epigenetic changes play an important role in modulating individual health status and aging. Thus, a main part of life expectance and healthy aging is determined by dietary habits and nutritional factors. Excessive or restricted food consumption have direct effects on health status. Moreover, some dietary interventions including a reduced intake of dietary calories without malnutrition, or a restriction of specific dietary component may promote health benefits and decrease the incidence of aging-related comorbidities, thus representing intriguing potential approaches to improve healthy aging. However, the relationship between nutrition, health and aging is still not fully understood as well as the mechanisms by which nutrients and nutritional status may affect health span and longevity in model organisms. The broad effect of different nutritional conditions on health span and longevity occurs through multiple mechanisms that involve evolutionary conserved nutrient-sensing pathways in tissues and organs. These pathways interacting each other include the evolutionary conserved key regulators mammalian target of rapamycin, AMP-activated protein kinase, insulin/insulin-like growth factor 1 pathway and sirtuins. In this review we provide a summary of the main molecular mechanisms by which different nutritional conditions, i.e., specific nutrient abundance or restriction, may affect health span and life span.

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Nutritional Epigenomics and Age-Related Disease

Cited by 26 publications

References 123 publications

Clinical epigenetics settings for cancer and cardiovascular diseases: real-life applications of network medicine at the bedside

Clinical epigenetics settings for cancer and cardiovascular diseases: real-life applications of network medicine at the bedside

How Are Epigenetic Modifications Related to Cardiovascular Disease in Older Adults?

Nutrients and Pathways that Regulate Health Span and Life Span

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