Nutritional etiology of breast cancer: Where are we now, and where are we going?

Waard, F. de

doi:10.1080/01635588209513743

Cited by 24 publications

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dietary factors have been repeatedly associated with the risk ofbreast cancer (BC) (Miller, 1981;de Waard, 1981;Wynder, 1980); some of them. especially dietary fat, in an adverse way, others, like vitamins: in a protective way.…”

mentioning

confidence: 99%

Liposoluble vitamins and lipid parameters in breast cancer. A joint study in northern Italy and southern France

Gerber¹,

Cavallo

Marubini

et al. 1988

Intl Journal of Cancer

View full text Add to dashboard Cite

The relationship between breast cancer, liposoluble vitamins, cholesterol and triglycerides was investigated by means of a hospital-based case-control study conducted at Milan (Italy) and Montpellier (France). These parameters were measured in blood samples taken from 319 cases and 344 controls. The interview included an evaluation of dietary intake of liposoluble vitamins. No difference emerged in liposoluble vitamin consumption, whereas a statistically significantly higher serum level of cholesterol and plasma level of vitamin E existed in cases compared to controls. The difference in plasma vitamin E was confirmed after adjustment for total cholesterol and triglycerides. In contrast, vitamin A variations appear to follow triglyceride trends. A multivariate analysis of the vitamin E plasma level was performed after classification of cases and controls according to quintile distribution of controls. All known risk factors plus age, serum total cholesterol and triglycerides were used as covariates. The odds ratio value for the highest quintile of plasma vitamin E is: 4.2 (1.9-9.0).

show abstract

mentioning

confidence: 99%

Liposoluble vitamins and lipid parameters in breast cancer. A joint study in northern Italy and southern France

Gerber¹,

Cavallo

Marubini

et al. 1988

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

Estrogen and progesterone receptors in breast cancer patients. Epidemiologic characteristics and survival differences

Ruder

Lubin

Wax

et al. 1989

Cancer

View full text Add to dashboard Cite

Risk factors commonly associated with breast cancer were studied in relation to: (1) tumor estrogen receptor (ER) or progesterone receptor (PR) status and (2) the presence of tumor hormone receptors in relation to subsequent survival. For 171 Israeli women diagnosed with breast cancer in 1976 to 1979, tumor hormone receptor status (positive if greater than 20 fmol receptors/mg protein; negative if less than or equal to 20 fmol/mg) and survival as of April 1984 were ascertained. There were 77 ER- versus 94 ER+ and (for 134 PR analyses) 69 PR- versus 65 PR+. Although ER status and PR status were found to be highly positively related, the epidemiologic features of women with an ER+ tumor were different from those with a PR+ tumor. Age tended to be associated positively with both ER+ and PR+. Being postmenopausal, older at menopause or at first birth, nulliparous, having more years of schooling, and a higher body mass index for older women or a lower body mass index for younger women were correlated positively with ER and negatively with PR. Among women with Stage III or IV tumors at diagnosis significant differences existed: restricted mean survival for follow-up time was 47.2 months for ER-, 73.8 months for ER+, 45.8 months for PR-, and 61.9 months for PR+. The combined hormone effects on survival at Stages III to IV showed a similar trend: restricted mean survival of 38.4 months for ER-PR-, intermediate survival with one positive hormone receptor status, and 74.6 months for ER+PR+.

show abstract

Weight gain with breast cancer adjuvant treatment

Levine

Raczynski

Carpenter

1991

Cancer

View full text Add to dashboard Cite

Available information suggests that individuals with breast cancer gain weight during adjuvant treatment and that this weight gain may be associated with poor prognosis. Exploration of the factors which affect weight gain may aid in developing weight control interventions for these patients. To determine the factors which are associated with weight gain, 32 women undergoing adjuvant chemotherapy were followed over 2 years from the beginning of adjuvant treatment. Measures of psychologic functioning and self-reports of exercise levels and eating were assessed every 2 months during the course of treatment. Sixty-nine percent of the women gained weight over treatment, resulting in a significant weight gain for the group as a whole. Weight gain was correlated positively with several psychologic measures but not with assessed biologic measures. A multiple-regression equation using psychologic/behavioral measures of emotional discharge, logical analysis, affective regulation, interpersonal sensitivity, average number of symptoms, and obsessive compulsiveness accounted for 58% of the variance in overall weight gain. At 2 years of follow-up, 27 women had gained weight for an average of 6.03 kg. The coping style of logical analysis emerged as a significant predictor of disease recurrence, accounting for 28% of the variance in weight gain at 2 years. The results are discussed in terms of identification of women likely to gain weight during adjuvant treatment, directions for future research, and development of interventions to control weight gain. Cancer 67:1954-1959,1991. ECENT STUDIES have shown a relationship between R body weight and recurrence of breast cancer,'-3 with heavier women having a poorer prognosis. Weight gain during adjuvant treatment among women with breast cancer has also been n ~ t e d. ~-~ Heasman et af.* found a mean weight gain over the course of chemotherapy of 4.3 kg in 96% of their sample of subjects. Weight gain did not seem to be related to chemotherapy type, although women receiving combination chemotherapy gained more weight than those receiving only one agent. It is possible that weight gain may also be related to the prognosis of breast cancer, although this question has not been studied adequately. Various hypotheses have been examined regarding the relationship between weight and incidence From the University of Alabama at Birmingham, Birmingham, Ala-bama.

show abstract

Nutritional etiology of breast cancer: Where are we now, and where are we going?

Cited by 24 publications

References 12 publications

Liposoluble vitamins and lipid parameters in breast cancer. A joint study in northern Italy and southern France

Liposoluble vitamins and lipid parameters in breast cancer. A joint study in northern Italy and southern France

Estrogen and progesterone receptors in breast cancer patients. Epidemiologic characteristics and survival differences

Weight gain with breast cancer adjuvant treatment

Contact Info

Product

Resources

About