Nutritional evaluation of children with chronic cholestatic disease

Silva, Francislaine Veiga da; Ferri, Priscila Menezes; Queiroz, Thaís Costa Nascentes; Barbosa, Pamela de Souza Haueisen; Oliveira, Maria Cristina Cassiano de; Pereira, Laura Jácome de Melo; Silva, Ana Cristina Simões e; Penna, Francisco José; Fagundes, Eleonora Druve Tavares; Ferreira, Alexandre Rodrígues

doi:10.1016/j.jped.2015.07.006

Cited by 16 publications

(18 citation statements)

References 17 publications

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“…It has been suggested that liver disease is more likely to cause malnutrition, especially severe malnutrition, than other diseases in children. However, the malnutrition prevalence was lower than in a recent study in Brazil (stunting 50·0 %, underweight 27·3 % and wasting 11·1 %, respectively) ( 5 ) . The difference may be attributed to the course and severity of the liver disease.…”

Section: Discussionmentioning

confidence: 62%

“…The human liver is an important regulator of metabolism, storage, synthesis and absorption of nutrients ( 2 ) . Nutritional deficiencies are common among people with chronic liver disease, especially in children ( 3 – 5 ) . The malnutrition prevalence in children with chronic liver disease may range from 9·1 to 71·1 % depending on the severity of liver disease ( 5 – 7 ) .…”

mentioning

confidence: 99%

“…Nutritional deficiencies are common among people with chronic liver disease, especially in children ( 3 – 5 ) . The malnutrition prevalence in children with chronic liver disease may range from 9·1 to 71·1 % depending on the severity of liver disease ( 5 – 7 ) . The development of malnutrition in childhood liver disease is complex and involves multiple mechanisms, including decreased dietary intake, impaired nutrient digestion and absorption, increased energy requirements and disordered substrate use ( 8 – 10 ) .…”

mentioning

confidence: 99%

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Prevalence of malnutrition and risk of undernutrition in hospitalised children with liver disease

Wang

Xiao

et al. 2017

J Nutr Sci

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Nutritional status of 380 hospitalised children aged from 1 month to 5 years with liver disease was evaluated in a single paediatric centre. The total prevalence of stunting (height-for-age Z (HAZ) < −2), underweight (weight-for-age Z (WAZ) < −2) and wasting (weight-for-height Z < −2) was 9·8, 9·0 and 7·9 %, respectively. The overall nutritional risk (−2 ≤ Z < −1) of stunting, underweight and wasting was 11·8, 12·9 and 12·6 %. The prevalence of undernutrition was significantly higher in children with cholestasis than children without cholestasis (stunting, 17·5 %/4·4 %, P < 0·001, and underweight, 14·9 %/4·9 %, P < 0·001). HAZ and WAZ scores were significantly higher in children without cholestasis than children with cholestasis (0·58 (sd 1·59)/−0·68 (sd 1·99), P < 0·001, and 0·37 (sd 1·35)/−0·47 (sd 1·75), P < 0·001). Further multivariate logistic regression analysis strengthened the evidence that cholestasis was significantly associated with undernutrition of stunting (OR = 4·18, P = 0·002) and underweight (OR = 3·26, P = 0·008), and suggested that the prevalence of stunting caused by infection was lower than other aetiologies in hospitalised children with liver disease (OR = 0·10, P = 0·002). We concluded that a high prevalence of malnutrition and risk of undernutrition presents in hospitalised young children with liver disease, especially in children with cholestasis. Nutrition assessment is recommended for hospitalised children with liver disease.

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Section: Discussionmentioning

confidence: 62%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Prevalence of malnutrition and risk of undernutrition in hospitalised children with liver disease

Wang

Xiao

et al. 2017

J Nutr Sci

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“…Foram encontrados sete artigos com menos de 10 anos de publicação passíveis de comparação com o presente estudo: quatro brasileiros [15][16][17][18] e três internacionais [19][20][21] . Esses estudos utilizaram os índices E/I e/ou DCT/I para a classificação do estado nutricional e os modelos PELD e/ou MELD e/ou o escore Child-Pugh para a classificação da gravidade da doença.…”

Section: Resultsunclassified

“…Já o segundo estudo mostrou prevalência de 50% de desnutrição. Pode-se observar nesses estudos que os escores de gravidade são bem mais elevados que os encontrados nas duas séries do HCPA, demonstrando um estado clínico bem mais comprometido (tabela 3 18 . Dos 91 pacientes avaliados, 25 apresentavam cirrose.…”

Section: Discussionunclassified