Nutritional Evaluation, Phytochemical Screening and Antimicrobial Effects of Aqueous Extract of Picralima nitida Peel

Obasi, NA; Okorie, Uchechukwu; Enemchukwu, B.N.; Ogundapo, Segun Solomon; Otuchristi, G.

doi:10.3923/ajbs.2012.105.112

Cited by 9 publications

(6 citation statements)

References 11 publications

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“…The percentages in ash content in leaves and fruits could be involved in important nutritional mineral elements [37]. The content of carbohydrate in roots was higher in comparison with the peel of Picralima nitida (37.7 ± 0.18%) [38] and so lower than the seeds of Saba florida (79.56 ± 0.033%) [39]. Calculated total energy in that P. tomentosa may encourage its use as a source of feed and fodder for animals and/or of possible human use in addition to its medicinal properties.…”

Section: Resultsmentioning

confidence: 99%

Nutritional Composition and Phytochemical, Antioxidative, and Antifungal Activities ofPergularia tomentosaL.

Lahmar¹,

Belghith

Abdallah³

et al. 2017

BioMed Research International

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Crude extracts from a medicinal Tunisian plant, Pergularia tomentosa L., were the investigated natural material. Butanolic extract of roots analyzed with IR spectra revealed the presence of hydroxyl, alcoholic, and carboxylic groups and sugars units. Analysis of some secondary metabolites, total phenolic, flavonoids, flavonols, and procyanidins, was performed using different solvents following the increased gradient of polarity. Fruits and leaves contained the highest amounts of all these compounds. Antioxidant properties were evaluated by the determination of free radical scavenging activity and the reducing power of methanolic extracts. Fruits and leaf extracts were the most powerful antioxidants for the two-assay in vitro system. Stems and fruits extracts exhibit an antifungal activity against Fusarium oxysporum f. sp. lycopersici which could become an alternative to synthetic fungicide to control Solanum species fungal diseases.

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Section: Resultsmentioning

confidence: 99%

Nutritional Composition and Phytochemical, Antioxidative, and Antifungal Activities ofPergularia tomentosaL.

Lahmar¹,

Belghith

Abdallah³

et al. 2017

BioMed Research International

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“…Consequently, these secondary metabolites will be the ones responsible for the antitussive and other activities that have been established for the plant in this work. Retrospective experiments have given similar secondary metabolites ( 57 58 ). Alkaloids in PNE could have contributed to its antitussive and analgesic activity as these have shown to have activity on μ and k opioid receptors e.g.…”

Section: Discussionmentioning

confidence: 94%

The possible mode of antitussive and expectorant activity of the ethanol seed extracts of Picralima nitida ((Stapf) Th. & H. Durand)

Dapaah

Koffuor

Mante

et al. 2017

Journal of Traditional and Complementary Medicine

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It has been established that Picralima nitida has antitussive effect. This study therefore aimed at determining the possible mode of antitussive and expectorant activity of an ethanolic seed extract of P. nitida (PNE). The muco-suppressant, mast cell stabilization, and the anxiolytic effects of PNE were ascertained using ammonium chloride-induced phenol red secretion in BALB/c mice; compound 48/80-induced mesenteric mast cell degranulation assay; and the open field and the elevated plus maze models respectively. Antibacterial potential was ascertained by the agar plate diffusion method and its antioxidant potential by the 2,2-diphenyl-1-picrylhydrazyl hydrate (DPPH) free radical scavenging, linoleic acid lipid peroxidation, reducing power, and total antioxidant assays. Data obtained was analyzed using One-way analysis of variance (ANOVA) with Dunnett's Multiple Comparison post hoc test. PNE (100–500 mg/kg) reduced (P ≤ 0.05–0.001) tracheal phenol red secretion. The extract (100–500 μg/ml) also dose-dependently (P ≤ 0.05–0.0001) stabilized mast cells. PNE (100–500 mg/kg) increased open arm activities in the elevated plus maze (P ≤ 0.05) as well as central zone exploration (P ≤ 0.05) in the open field test. PNE (10–50 mg/ml) showed activity against Staphylococcus aureus, Streptococcus pneumonia, Escherichia coli, Klebsiella pneumonia, and Salmonella typhi. By the assays, PNE showed significant antioxidant effect. The ethanolic seed extract of P. nitida has demonstrated very significant mast cell stabilizing, mucus suppressant, and antioxidant activity as well as substantial antibacterial and anxiolytic properties; all of which could contribute to its antitussive and expectorant property.

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“…Although this study did not focus on the bioactive compounds present in this plant, several studies have previously shown that various extracts of this plant are good sources of phytochemicals [ 26 , 27 , 30 , 33 , 70 ]. More specifically, the seed extract of the P. nitida has been reported to contain glycosides, alkaloids, triterpenes flavonoids, polyphenols, saponins, and tannins [ 31 , 33 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

Protective Role of Picralima nitida Seed Extract in High-Fat High-Fructose-Fed Rats

Campos

Osaigbovo

Bisi-Adeniyi

et al. 2020

Advances in Pharmacological and Pharmaceutical Sciences

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Picralima nitida is a therapeutic herb used in ethnomedicine for the management of several disease conditions including diabetes. This study examined the potential palliative effect of aqueous seed extract of Picralima nitida (APN) on dyslipidemia, hyperglycemia, oxidative stress, insulin resistance, and the expression of some metabolic genes in high-fat high-fructose-fed rats. Experimental rats (2 months old) were fed a control diet or a high-fat diet with 25% fructose (HFHF diet) in their drinking water for nine weeks. APN was administered orally during the last four weeks. Anthropometric and antioxidant parameters, lipid profile, plasma glucose, and insulin levels and the relative expression of some metabolic genes were assessed. APN caused a significant decrease ( P < 0.05 ) in weight gained, body mass index, insulin resistance, plasma glucose, and insulin levels. High-density lipoprotein cholesterol level was significantly increased ( P < 0.05 ), while triacylglycerol, cholesterol, low-density lipoprotein, cardiac index, atherogenic index, coronary artery index, and malondialdehyde levels in plasma and liver samples were also significantly decreased ( P < 0.05 ) by APN at all experimental doses when compared to the group fed with an HFHF diet only. APN also significantly ( P < 0.05 ) upregulated the relative expression of glucokinase, carnitine palmitoyltransferase-1 (CPT-1), and leptin at 400 mg/kg body weight when compared to the group fed with an HFHF diet only. This study showed that APN alleviated dyslipidemia, hyperglycemia, and oxidant effect associated with the intake of a high-fat high-fructose diet.

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Nutritional Evaluation, Phytochemical Screening and Antimicrobial Effects of Aqueous Extract of Picralima nitida Peel

Cited by 9 publications

References 11 publications

Nutritional Composition and Phytochemical, Antioxidative, and Antifungal Activities ofPergularia tomentosaL.

Nutritional Composition and Phytochemical, Antioxidative, and Antifungal Activities ofPergularia tomentosaL.

The possible mode of antitussive and expectorant activity of the ethanol seed extracts of Picralima nitida ((Stapf) Th. & H. Durand)

Protective Role of Picralima nitida Seed Extract in High-Fat High-Fructose-Fed Rats

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