Nutritional factors and survival of patients with oral cancer

Liu, Shih–An; Tsai, Wen‐Chen; Wong, Yong–Kie; Lin, Jin‐Ching; Poon, Chiu-Kwan; Chao, Shou-Yee; Hsiao, Ying-Lyung; Chan, Man-Yee; Cheng, Ching-An; Wang, Chen‐Chi

doi:10.1002/hed.20461

Cited by 84 publications

(82 citation statements)

References 18 publications

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“…Co-existence of smoking and tobacco chewing in drinkers is highly apparent in those consuming less vegetables and fruits (Cancela et al, 2009). Better pre-operative nutritional status helps in improving the survival of OC patients (Liu et al, 2006). The situation may be further complicated by poor socio-economic conditions.…”

Section: Mortality and Survivalmentioning

confidence: 99%

Epidemiology of Oral Cancer in Asia in the Past Decade- An Update (2000-2012)

Rao¹,

Mejía²,

Roberts‐Thomson³

et al. 2013

Asian Pacific Journal of Cancer Prevention

407

256

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The prevalence of oral cancers (OC) is high in Asian countries, especially in South and Southeast Asia. Asian distinct cultural practices such as betel-quid chewing, and varying patterns of tobacco and alcohol use are important risk factors that predispose to cancer of the oral cavity. The aim of this review is to provide an update on epidemiology of OC between 2000 and 2012. A literature search for this review was conducted on Medline for articles on OC from Asian countries. Some of the articles were also hand searched using Google. High incidence rates were reported from developing nations like India, Pakistan, Bangladesh, Taiwan and Sri Lanka. While an increasing trend has been observed in Pakistan, Taiwan and Thailand, a decreasing trend is seen in Philippines and Sri Lanka. The mean age of occurrence of cancer in different parts of oral cavity is usually between 51-55 years in most countries. The tongue is the leading site among oral cancers in India. The next most common sites in Asian countries include the buccal mucosa and gingiva. The 5 year survival rate has been low for OC, despite improvements in diagnosis and treatment. Tobacco chewing, smoking and alcohol are the main reasons for the increasing incidence rates. Low socioeconomic status and diet low in nutritional value lacking vegetables and fruits contribute towards the risk. In addition, viral infections, such as HPV and poor oral hygiene, are other important risk factors. Hence, it is important to control OC by screening for early diagnosis and controlling tobacco and alcohol use. It is also necessary to have cancer surveillance at the national-level to collect and utilise data for cancer prevention and control programs.

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Section: Mortality and Survivalmentioning

confidence: 99%

Epidemiology of Oral Cancer in Asia in the Past Decade- An Update (2000-2012)

Rao¹,

Mejía²,

Roberts‐Thomson³

et al. 2013

Asian Pacific Journal of Cancer Prevention

407

256

View full text Add to dashboard Cite

show abstract

“…No signiWcant evolution in the management of oral cancer has been developed in recent years. Even though better combinations of locoregional treatment modalities have improved the quality of life after diagnosis, the relative 5-year survival rate has not changed much over the past decades [2]. Consequently, recognition of poor prognostic factors has become a focus in the literature.…”

Section: Introductionmentioning

confidence: 99%

Somatic mutations in the D-loop of mitochondrial DNA in oral squamous cell carcinoma

Liu

Jiang

Chen³

et al. 2011

Eur Arch Otorhinolaryngol

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We aimed to characterize somatic mutations in the D-loop of mitochondrial DNA (mtDNA) and their impact on survival in oral squamous cell carcinoma patients in an endemic betel quid chewing area. Histologically confirmed oral cancer and corresponding non-tumor tissues were obtained from 59 patients. The D-loop of mtDNA sequence in a patient's non-cancerous tissues was compared with that of paired oral cancer samples and any sequence differences were identified as somatic mutations. With a median follow-up of 16 months, somatic mutations of the D-loop were observed in 38 (64.4%) patients and most of them occurred in the poly-C tract. There was no significant difference between the mutation group and non-mutation group in age, gender, primary site, histological features, pathological stage, smoking, betel quid chewing, alcohol consumption, and postoperative radiotherapy. However, patients with D-loop mutations have better survival (2 year disease specific survival rate: 73.4 vs. 45.0%, P = 0.0374). A high rate of somatic mutations in the D-loop region of mtDNA was found in betel quid-related oral squamous cell carcinoma patients. Somatic mutation of D-loop of mtDNA was associated with better survival.

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“…31 Liu S et al also demonstrated that pretreatment serum albumin levels are independent indicator of prognosis for patients with oral cavity cancer. 34 A prospective cohort study of 170 patients with advanced cancer, where lung (34%), liver (14%), and lower gastrointestinal tract (14%) malignancies accounted for almost two thirds of the primary cancers, enrolled into the palliative care unit of a regional hospital in Hong Kong demonstrated that serum albumin is an independent predictor of survival. 35 Furthermore, these findings have also been reproduced in carcinoma of lung cancer, pancreatic cancer, gastric cancer, colorectal cancer and breast cancer with increasing evidence that serum albumin can be a prognostic factor in cancer.…”

Section: Discussionmentioning

confidence: 99%

“…A vast majority (>70%) of more than one billion population of India lives in rural areas, which have inadequate access to trained providers and limited health services. As a result, most of the cases are diagnosed at later stages which result in low treatment outcomes and poor 5-year survival rate of approximately 37% (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45). 2 Various clinical, biochemical, and histological prognostic factors have been identified in the literature, some generic to all cancers and some specific for oral cavity cancer.…”

Section: Introductionmentioning

confidence: 99%