Nutritional impact on Immunological maturation during Childhood in relation to the Environment (NICE): a prospective birth cohort in northern Sweden

Barman, Malin; Murray, Fiona; Bernardi, Angelina I.; Broberg, Karin; Bölte, Sven; Hesselmar, Bill; Jacobsson, Bo; Jönsson, Karin; Kippler, Maria; Rabe, Hardis; Ross, Alastair B.; Sjöberg, Fei; Strömberg, Nicklas; Vahter, Marie; Wold, Agnes E.; Sandberg, Ann Sofie; Sandin, Anna

doi:10.1136/bmjopen-2018-022013

Cited by 28 publications

(31 citation statements)

References 48 publications

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“…In the ongoing Nutritional impact on Immunological maturation during Childhood in relation to the Environment (NICE) birth-cohort, the ways in which exposure to different agents during pregnancy and in early life affects the subsequent health status of the infants are being explored. The primary aim of the NICE study is to investigate the effects of exposures to key environmental factors, such as nutrition, microbes, environmental toxins, and lifestyle, during both pregnancy and early childhood on the maturation of the infant’s immune system, as well as on the development of sensitization and allergy, infant growth, neurological development, and oral health [9]. A detailed examination of the maternal diet during pregnancy is an important and an essential component of the NICE cohort, as the maternal diet during pregnancy is associated with many different outcomes, both during pregnancy and during childhood.…”

Section: Introductionmentioning

confidence: 99%

Food and Nutrient Intake during Pregnancy in Relation to Maternal Characteristics: Results from the NICE Birth Cohort in Northern Sweden

et al. 2019

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Linkages between diet and other lifestyle factors may confound observational studies. We used cluster analysis to analyze how the intake of food and nutrients during pregnancy co-varies with lifestyle, clinical and demographic factors in 567 women who participated in the NICE (nutritional impact on immunological maturation during childhood in relation to the environment) birth-cohort in northern Sweden. A food frequency questionnaire, Meal-Q, was administered in pregnancy Week 34, and the reported food and nutrient intakes were related to maternal characteristics such as age, education, rural/town residence, parity, pre-pregnancy smoking, first-trimester BMI, allergy and hyperemesis. Two lifestyle-diet clusters were identified: (1) High level of education and higher age were related to one another, and associated with a diet rich in fruits, vegetables, whole grains and fish, and (2) smoking before pregnancy and higher BMI in early pregnancy were related to one another and associated with a diet that contained white bread, French fries, pizza, meat, soft drinks, candy and snacks. More than half of the women had lower-than-recommended daily intake levels of vitamin D, folate, selenium, and iodine. Complex lifestyle-diet interactions should be considered in observational studies that link diet and pregnancy outcome.

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Section: Introductionmentioning

confidence: 99%

Food and Nutrient Intake during Pregnancy in Relation to Maternal Characteristics: Results from the NICE Birth Cohort in Northern Sweden

et al. 2019

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“…Such early encounters between SpaP A/B/C and Cnm/Cbm types and the host innate and adaptive immunity may shape distinct long-lasting immunity and inflammation responses. Thus, the perinatal and infancy period may represent a window of opportunity for establishing long-lasting conditions beneficial to oral and general health [37], and the association of Cnm types and tooth loss with stroke and systemic risk further emphasizes the potential of exploring S. mutans phenotypes in the prevention of caries early in life.…”

Section: Discussionmentioning

confidence: 99%

Dynamics, cariogenicity, and geographic distribution of Streptococcus mutans adhesin types suggest adaptation to individual hosts

Sheng

Esberg

Mårell

et al. 2019

Preprint

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Dental caries, the most common chronic infectious disease, involve Streptococcus mutans SpaP A/B/C and Cnm/Cbm adhesin types of different virulence. We have explored their stability and dynamics over 5 years, their geographic distribution, as well as the potentially increased cariogenicity of specific SpaP B subtypes. We performed qPCR and TaqMan typing using whole saliva and isolates from 452 Swedish adolescents followed from 12 to 17 years of age. Approximately 50% of the children were infected at baseline with a single dominant (44%) or mixed (6%) SpaP A, B, or C type, some of which were also Cnm (6%) or Cbm (1%) positive. Stability (+, +) was high for S. mutans infection (85%) and dominant SpaP A or C (80% and 67%) and Cnm or Cbm (85% and 100%) types, but low for SpaP B (51%) and mixed SpaP A/B/C types (26%). Only five children switched from one SpaP type to another, and none between Cnm and Cbm types. Mixed SpaP A/B/C types were typically lost or changed into dominant types. Moreover, children infected with Cnm (n=26) types were more frequent in the northern (Skellefteå) region (p = 0.0041), and those with Cbm types (n=7) in the southern (Umeå) region. Children infected with SpaP B-2 subtypes had a doubled caries experience (p = 0.009) and 5-year caries increment (p = 0.02) compared to those infected with SpaP A. In conclusion, the stable dominant but instable mixed adhesin types and geographic differentiation of Cnm and Cbm types suggest adaptation of low and high cariogenicity types to specific individuals. Swedish adolescents followed from 12 to 17 years of age [7,11,12]. Accordingly, children infected with S. mutans SpaP B and Cnm adhesin types developed more caries than those infected with SpaP A or C and Cbm types or non-infected children [7]. The Cnm phenotype, which occurs in 6% of adolescents, has been implicated in endocarditis and stroke [13][14][15].Both Cnm and SpaP B, one of the three core genome SpaP A, B, or C adhesin types in S. mutans biotypes A, B, and C, exhibit increased acid tolerance and binding to saliva pattern recognition receptor DMBT1 [7,16,17]. Moreover, sequence typing of 70 caries-free and decayed extreme cases suggested a cluster or subgroup of SpaP B-2 types with increased cariogenicity [7]. However, the high cariogenic nature of SpaP B-2 types remains to be verified in the entire sample of 452 adolescents.S. mutans infects 40-80% of subjects and is transmitted similarly to the oral and gut microbiomes from parent to child [18,19]. Infection by S. mutans is dominated by one or a few phenotypes, such as the SpaP A, B, or C adhesin types [18,19], whereas genotype diversity in oral streptococci increases with extent of sequencing [20]. The S. mutans adhesin types and oral, gut, and other microbiomes colonize their niches in a stable fashion over time, though quantitative fluctuations occur in response to antibiotic treatment, traveling, breast feeding, and unknown factors [7,21-23]. However, whether S. mutans adapts to host receptor repertoires similar to uropathogenic Escherich...

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“…Protocol TIPS: (1) The cotton ball should be wet but soft and allow pups to hide below; (2) mice like corners. Place cotton balls on all corners would help their survivals; and (3) Different sources of milk may have an impact on neonate's immune system [8,9]. The specific milk (Enfamil ProSobee Soy Sensitive Baby Formula) may enhance baby's immune response, however, due to the short duration time (up to 7 d), the effects may be marginal.…”

Section: Pol Scientificmentioning

confidence: 99%

A simple method for short-term maintenance of neonatal mice without foster mothers

et al. 2020

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Mice are typically weaned from their mother between 21 and 28 days of age, or at 10 grams of body weight. However, some biochemical experiments need to be done before the weaning days, and the mother might cannibalize or ignore those manipulated pups. Here, we provide a detailed protocol for maintenance of neonatal mice without the presence of their mothers for biomedical research. The basic instinct of neonate mice to hide under covers is harnessed for their survival in a mother-free environment. When covers are soaked with milk and the only targets for hiding, the neonates would acquire their nutrients at least in an involuntary fashion. The protocol is simple and can be used for neonatal rodent studies for short periods of times, and assures the accuracy of the biomedical experiments if survival rate of neonates is critical.

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Nutritional impact on Immunological maturation during Childhood in relation to the Environment (NICE): a prospective birth cohort in northern Sweden

Cited by 28 publications

References 48 publications

Food and Nutrient Intake during Pregnancy in Relation to Maternal Characteristics: Results from the NICE Birth Cohort in Northern Sweden

Food and Nutrient Intake during Pregnancy in Relation to Maternal Characteristics: Results from the NICE Birth Cohort in Northern Sweden

Dynamics, cariogenicity, and geographic distribution of Streptococcus mutans adhesin types suggest adaptation to individual hosts

A simple method for short-term maintenance of neonatal mice without foster mothers

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