Two experiments were conducted to study the effect of autoclaving and heat processing (HP) and enzyme supplementation on wheat nutritive value for quails. In the first experiment, 72 male quails (13 weeks) were used to determine apparent metobalisable energy corrected for nitrogen (AMEn) of wheat samples. In the second experiment, 720 seven-day-old as-hatched Japanese quail were randomly assigned to a 3 )3 factorial design. Factors include three processing methods (untreated, autoclaving and HP) and three levels of enzyme (0, 0.25 and 0.5 g/kg). Each treatment group consisted of 4 replicates of 20 birds. According to the results, the total and insoluble none starch polysaccharides (NSP) and insoluble to soluble NSP ratio increased by processing (PB0.01) and also total and insoluble b-glucan increased by processing (PB0.01). The amount of AME, AMEn, gross energy efficiency and dry matter digestibility of wheat has significantly increased by autoclaving (P B0.05). Quails performance was increased by wheat autoclaving (PB0.05). However, wheat dry heat processing had no significant effect on performance. Adding enzyme to diet significantly improved quails performance. By autoclaving wheat, carcass and breast weight significantly increased (PB0.05). Adding enzyme to diet significantly increased breast and thigh weight (P B0.05). In conclusion, we can use autoclaving, in spite of enzyme supplementation, to improve growth rate and feed conversion ratio of growing quail fed diets based on wheat.