Nutritional Influences on Reproduction: A Functional Approach

Horn, Brandon; Yu, Wendy

doi:10.1007/978-3-030-30730-1_32

Cited by 3 publications

(2 citation statements)

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“…Thiamine (B1) deficiency leads to a higher embryonic mortality and pathological changes in the internal organs of the fetuses due to cardiovascular and nervous system development disorders in the implantation period of blastocyst and gastrula [ 26 ]. Deficiency of riboflavin (B2) tends to slow down the growth and differentiation of the fetal tissues and leads to missed miscarriage in severe cases [ 27 , 28 ]. Niacin (B6) is involved in the synthesis of steroid, including sex hormones, and hormonal status disorders caused by its deficiency result in fertility decline and pregnancy termination [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

“…Niacin (B6) is involved in the synthesis of steroid, including sex hormones, and hormonal status disorders caused by its deficiency result in fertility decline and pregnancy termination [ 29 ]. Pyridoxine (B12) deficiency brings about anorexia, weight loss, pathological changes of internal organs (liver, lungs, and ovaries), slower puberty, and sterility [ 27 ]. Deficiency of fat-soluble vitamins can also affect a reproductive function: given retinol deficiency, the number of spermatogonia and sperm cells, as well as a testosterone synthesis and a number of fetuses' ovarian cells tend to decrease, while the above deficiency was found to increase the content of follicle stimulating hormone, atypical nuclei in Sertoli cells, germ cell apoptosis [ 30 , 31 ].…”

Section: Resultsmentioning

confidence: 99%

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The Use of the Adaptation Potential Reduction Model for Reproductive Toxicity Research In Vivo

Тышко

Sadykova

Shestakova

et al. 2020

Journal of Toxicology

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The modeling of adaptation potential decrease in rats due to modification of the diet’s vitamin–mineral composition allows to increase animals’ sensitivity to toxic load in reprotoxicological experiments. The threshold values of vitamins B1, B2, B3, and B6 and mineral substances Fe3+ and Mg2+ in the diet, which lead to a considerable reduction of laboratory animals’ adaptation potential, have been determined as 19% (from the basic level in the diet) for males and 18% for females. The efficiency of this model has been confirmed in a reprotoxicological experiment with glyphosate as a toxic factor: the action of the toxic factor against the background of reduced availability of B vitamins and salts Fe3+ and Mg2+ led to significant changes in such indicators of reproductive function as mating efficiency, postimplantation loss, and the total number of alive pups, while the toxic effect of glyphosate was not so pronounced against the normal level of essential substances. The obtained results prove that this adaptation potential reduction model can be recommended for the research of the low-toxicity objects reproductive toxicity in rats and for the safety assessment of novel food, in particular.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The Use of the Adaptation Potential Reduction Model for Reproductive Toxicity Research In Vivo

Тышко

Sadykova

Shestakova

et al. 2020

Journal of Toxicology

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MicroRNA-26b-3p inhibits human trophoblast cell proliferation, invasion and resistance to apoptosis via targeting SHBG

et al. 2020

Journal of King Saud University - Science

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Apigenin as a Promising Agent for Enhancing Female Reproductive Function and Treating Associated Disorders

Sirotkin,

Harrath

2024

Biomedicines

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Apigenin is an organic flavonoid abundant in some plants such as parsley, chamomile, or celery. Recently, it has been investigated for several of its pharmacological characteristics, such as its ability to act as an antioxidant, reduce inflammation, and inhibit the growth of cancer cells. The purpose of this review is to provide a summary of the existing knowledge regarding the effects of apigenin on female reproductive systems and its dysfunctions. Apigenin can influence reproductive processes by regulating multiple biological events, including oxidative processes, cell proliferation, apoptosis, cell renewal and viability, ovarian blood supply, and the release of reproductive hormones. It could stimulate ovarian folliculogenesis, as well as ovarian and embryonal cell proliferation and viability, which can lead to an increase in fertility and influence the release of reproductive hormones, which may exert its effects on female reproductive health. Furthermore, apigenin could inhibit the activities of ovarian cancer cells and alleviate the pathological changes in the female reproductive system caused by environmental pollutants, harmful medications, cancer, polycystic ovarian syndrome, ischemia, as well as endometriosis. Therefore, apigenin may have potential as a biostimulator for female reproductive processes and as a therapeutic agent for certain reproductive diseases.

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Nutritional Influences on Reproduction: A Functional Approach

Cited by 3 publications

References 372 publications

The Use of the Adaptation Potential Reduction Model for Reproductive Toxicity Research In Vivo

The Use of the Adaptation Potential Reduction Model for Reproductive Toxicity Research In Vivo

MicroRNA-26b-3p inhibits human trophoblast cell proliferation, invasion and resistance to apoptosis via targeting SHBG

Apigenin as a Promising Agent for Enhancing Female Reproductive Function and Treating Associated Disorders

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