Nutritional Intake Influences Zinc Levels in Preterm Newborns: An Observational Study

Terrin, Gianluca; Boscarino, Giovanni; Chiara, Maria Di; Iacobelli, Simona; Faccioli, F.; Greco, Carla; Onestà, Elisa; Sabatini, Giulia; Pietravalle, Andrea; Oliva, Salvatore; Conti, Maria Giulia; Natale, Fabio; Curtis, Mario De

doi:10.3390/nu12020529

Cited by 34 publications

(19 citation statements)

References 40 publications

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“…The nutrition of the preterm neonates to catch up growth may elevate zinc consumption so zinc supplementation may be needed even if the preterm neonates had initial normal serum zinc levels and Preterm neonates may have higher zinc requirements than previously recommended. [26] The results of these studies which with or against our study raise the attention of the need of further studies in the same topic to reach a solid recommendation to use or not to use zinc supplementation in preterm neonates with jaundice.…”

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confidence: 59%

WITHDRAWN: Zinc Supplementation in Preterm Neonates with Jaundice: Is It Beneficial?

Elfarargy¹,

Ashmawy

Abu-Risha

et al. 2020

Preprint

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Background: Neonatal jaundice is a common neonatal disease which had adverse effect in the neonates especially preterm neonates when the level of indirect bilirubin is high enough to pass the blood brain barrier causing bilirubin encephalopathy or kernicterus. Aim: The aim of this study is to investigate the value of zinc (Zn) supplementation in preterm neonates with jaundice and if it will be beneficial or not. Patients and methods: A prospective randomized clinical trial (RCT) study, identification number is TCTR20200504007, which was done at Tanta University Hospital (TUH) from July 2016 to March 2018 on 200 preterm neonates suffering from neonatal jaundice. The studied neonates were divided into 2 groups: group 1, which received Zn and phototherapy, and group 2, which received phototherapy only and did not take Zn. In the group 1, 100 preterm neonates with jaundice received Zn as 0.6 ml(cm3) of zinc origin/kg/day orally through oro/nasogastric tube divided into 2 doses (/12 hours) which is equal 1.2 mg elemental zinc/kg/day orally for 10 day. Results: There was no significant difference in serum bilirubin between the 2 groups in the 2nd, 4th and 6th day of admission while the serum bilirubin was significantly decreased in neonates who were treated by Zn and phototherapy in group 1, compared with neonates of group 2 who were treated with phototherapy only in the 8th , 9th and 10th day of admission where the p value was 0.045* ,0.027* and 0.004* respectively. Conclusion: Zn administration in jaundiced preterm neonates is beneficial in decreasing serum bilirubin. Recommendation: Zn supplementation for jaundiced preterm neonates.

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confidence: 59%

WITHDRAWN: Zinc Supplementation in Preterm Neonates with Jaundice: Is It Beneficial?

Elfarargy¹,

Ashmawy

Abu-Risha

et al. 2020

Preprint

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“…In particular, GA, BW, gender, type of delivery, twin pregnancy, antenatal steroid administration, Apgar score at the 1st and 5th min after birth, pH on cord blood at birth, body temperature at the 1st h of life, Clinical Risk Index for Babies II score (CRIB II), death, and need of invasive mechanical ventilation were recorded ( 16 ). Diagnosis of the major morbidities associated with prematurity, such as necrotizing enterocolitis (Bell stage ≥2), bronchopulmonary dysplasia, IVH, PVL, retinopathy of prematurity, and sepsis proven by positive cultures, were performed according to the standard criteria and recorded in the reporting form, as previously described ( 17 , 18 ). Data on daily enteral and parenteral nutritional intake were collected during the first week of life.…”

Section: Methodsmentioning

confidence: 99%

Early Protein Intake Influences Neonatal Brain Measurements in Preterms: An Observational Study

et al. 2020

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Introduction: To limit extrauterine growth restriction, recent guidelines on nutrition of preterm neonates recommended high protein intake since the first day of life (DOL). The impact of this nutritional strategy on the brain is still controversial. We aimed to evaluate the effects of protein intake on early cerebral growth in very low birth weight newborns. Materials and Methods: We performed serial cranial ultrasound (cUS) scans at 3-7 DOL and at 28 DOL in very low birth weight newborns consecutively observed in the neonatal intensive care unit. We analyzed the relation between protein intake and cerebral measurements at 28 DOL performed by cUS. Results: We enrolled 100 newborns (gestational age 29 ± 2 weeks, birth weight 1,274 ± 363 g). A significant (p < 0.05) positive correlation between enteral protein intake and biparietal diameter (r = 0.490 * *), occipital-frontal diameter (r = 0.608 * *), corpus callosum (length r = 0.293 * , genu r = 0.301 *), caudate head (right r = 0.528 * * , left r = 0.364 * *), and cerebellum (transverse diameter r = 0.440 * * , vermis height r = 0.356 * * , vermis width r = 0.377 * *) was observed at 28 DOL. Conversely, we found a significant negative correlation of protein intake given by parenteral nutrition (PN) with biparietal diameter (r = −0.524 * *), occipital-frontal diameter (r = −0.568 * *), body of corpus callosum (r = −0.276 *), caudate head (right r = −0.613 * * , left r = −0.444 * *), and cerebellum (transverse diameter r = −0.403 * * , vermis height r = −0.274 * , vermis width r = −0.462 * *) at 28 DOL. Multivariate regression analysis showed that measurements of occipital-frontal diameter, caudate head, and cerebellar vermis at 28 DOL depend positively on protein enteral intake (r = 0.402 * , r = 0.305 * , and r = 0.271 *) and negatively by protein parenteral intake (r = −0.278 * , r = −0.488 * , and r = −0.342 *). Conclusion: Brain development in neonatal life depends on early protein intake. High protein intake affects cerebral structures' measurements of preterm newborn when administered by PN. Positive impact on brain development encourages the administration of recommended protein intake mainly by enteral nutrition.

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“…Data on survival, morbidity, and duration of hospital stay were collected in a separate and codified data form. Diagnosis of the main neonatal morbidities was performed according to the standard criteria by physicians unaware of the study design and aims as previously described ( 26 , 27 ). Nutritional management was performed as previously described ( 24 , 26 , 28 ).…”

Section: Methodsmentioning

confidence: 99%

Echocardiography-Guided Management of Preterms With Patent Ductus Arteriosus Influences the Outcome: A Cohort Study

et al. 2020

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Introduction: Echocardiography (ECHO) with color flow Doppler is considered as the gold standard to identify a hemodynamic patent ductus arteriosus (hs-PDA). However, the optimal diagnostic and therapeutic management for newborns with hs-PDA is still controversial. We aimed to investigate two clinical strategies: (1) targeted treatment based on ECHO criteria and (2) treatment based on ECHO criteria in addition to clinical signs and symptoms.Materials and Methods: This is a cohort study including all neonates consecutively admitted in the Neonatal Intensive Care Unit of University La Sapienza in Rome, with gestational age <32 weeks or body birth weight <1,500 g and with a diagnosis of hs-PDA as confirmed by ECHO evaluation performed within 72 h of life. We classified the babies in two cohorts: (A) pharmacological treatment immediately after ECHO screening and (B) pharmacological therapy for PDA was administered when the relevance of a hs-PDA was associated with clinical signs of hemodynamic instability.Results: We considered as primary outcome newborns who survived without any morbidities (A: 48.1% vs. B: 22.2%, p = 0.022). In particular, we found that the rate of intraventricular hemorrhage stage ≥2 was increased in cohort B (A: 3.7% vs. B 24.4%, p = 0.020). A multivariate analysis showed that assignment to cohort A independently influences the primary outcome.Conclusions: Adopting an hs-PDA management option based on ECHO-directed therapy regardless of symptoms may reduce the morbidity and improve the survival of very low birth weight infants.

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Nutritional Intake Influences Zinc Levels in Preterm Newborns: An Observational Study

Cited by 34 publications

References 40 publications

WITHDRAWN: Zinc Supplementation in Preterm Neonates with Jaundice: Is It Beneficial?

WITHDRAWN: Zinc Supplementation in Preterm Neonates with Jaundice: Is It Beneficial?

Early Protein Intake Influences Neonatal Brain Measurements in Preterms: An Observational Study

Echocardiography-Guided Management of Preterms With Patent Ductus Arteriosus Influences the Outcome: A Cohort Study

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