Nutritional intervention in chronic pain: an innovative way of targeting central nervous system sensitization?

Nijs, Jo; Yılmaz, Sevilay Tümkaya; Elma, Ömer; Tatta, Joe; Mullie, Patrick; Vanderweeën, Luc; Clarys, Peter; Deliens, Tom; Coppieters, Iris; Weltens, Nathalie; Oudenhove, Lukas Van; Huysmans, Eva; Malfliet, Anneleen

doi:10.1080/14728222.2020.1784142

Cited by 40 publications

(44 citation statements)

References 115 publications

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“…Another pitfall for clinicians applying a pain phenotyping approach is that one might neglect the individual variability within one pain phenotype. Therefore, precision medicine for patients with chronic pain is more than accounting for CS, and it also implies addressing relevant comorbidities, such as insomnia [ 73 ] and obesity [ 74 ], and lifestyle factors that sustain CS, such as stress [ 75 ], physical inactivity [ 76 ] and unhealthy diet [ 77 ], depending on the individual patient characteristics.…”

Section: The Futurementioning

confidence: 99%

Nociplastic Pain Criteria or Recognition of Central Sensitization? Pain Phenotyping in the Past, Present and Future

Nijs

Lahousse

Kapreli

et al. 2021

JCM

Self Cite

198

127

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Recently, the International Association for the Study of Pain (IASP) released clinical criteria and a grading system for nociplastic pain affecting the musculoskeletal system. These criteria replaced the 2014 clinical criteria for predominant central sensitization (CS) pain and accounted for clinicians’ need to identify (early) and correctly classify patients having chronic pain according to the pain phenotype. Still, clinicians and researchers can become confused by the multitude of terms and the variety of clinical criteria available. Therefore, this paper aims at (1) providing an overview of what preceded the IASP criteria for nociplastic pain (‘the past’); (2) explaining the new IASP criteria for nociplastic pain in comparison with the 2014 clinical criteria for predominant CS pain (‘the present’); and (3) highlighting key areas for future implementation and research work in this area (‘the future’). It is explained that the 2021 IASP clinical criteria for nociplastic pain are in line with the 2014 clinical criteria for predominant CS pain but are more robust, comprehensive, better developed and hold more potential. Therefore, the 2021 IASP clinical criteria for nociplastic pain are important steps towards precision pain medicine, yet studies examining the clinimetric and psychometric properties of the criteria are urgently needed.

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Section: The Futurementioning

confidence: 99%

Nociplastic Pain Criteria or Recognition of Central Sensitization? Pain Phenotyping in the Past, Present and Future

Nijs

Lahousse

Kapreli

et al. 2021

JCM

Self Cite

198

127

View full text Add to dashboard Cite

show abstract

“…In the context of CNCP, an aspect of systemic inflammation of particular interest manifests in the central nervous system. This neuroinflammation is mediated by neuroglia cells, which are found in the brain and central nervous system [ 19 ]. They are thought to be activated by overall poor dietary patterns (i.e., energy-dense, nutrient-poor diets) through a variety of mechanisms such as oxidative stress, peripheral inflammation, and changes in the gut microbiome [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

“…This neuroinflammation is mediated by neuroglia cells, which are found in the brain and central nervous system [ 19 ]. They are thought to be activated by overall poor dietary patterns (i.e., energy-dense, nutrient-poor diets) through a variety of mechanisms such as oxidative stress, peripheral inflammation, and changes in the gut microbiome [ 19 ]. This leads to central nervous system sensitisation, a dominant contributor to CNCP [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…They are thought to be activated by overall poor dietary patterns (i.e., energy-dense, nutrient-poor diets) through a variety of mechanisms such as oxidative stress, peripheral inflammation, and changes in the gut microbiome [ 19 ]. This leads to central nervous system sensitisation, a dominant contributor to CNCP [ 19 , 20 ]. The corollary of this is that the adoption of a high-quality diet facilitates normalisation of glial activity and reduced central nervous system inflammation and sensitisation [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Diet and Chronic Non-Cancer Pain: The State of the Art and Future Directions

Brain

Burrows

Bruggink

et al. 2021

JCM

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Nutrition plays an important role in pain management. Healthy eating patterns are associated with reduced systemic inflammation, as well as lower risk and severity of chronic non-cancer pain and associated comorbidities. The role of nutrition in chronic non-cancer pain management is an emerging field with increasing interest from clinicians and patients. Evidence from a number of recent systematic reviews shows that optimising diet quality and incorporating foods containing anti-inflammatory nutrients such as fruits, vegetables, long chain and monounsaturated fats, antioxidants, and fibre leads to reduction in pain severity and interference. This review describes the current state of the art and highlights why nutrition is critical within a person-centred approach to pain management. Recommendations are made to guide clinicians and highlight areas for future research.

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“…Based on preclinical studies, it is hypothesized that central (and peripheral) nervous system function could be mediated via a gut-brain axis [5]. The gut microbiota interacts with the host immune, metabolic, endocrine and nervous systems.…”

mentioning

confidence: 99%

Osteoarthritis Related Pain: Which Procedure is the Optimal Choice?

2021

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Osteoarthritis (OA) is not simply a matter of mechanical damage and several risk factors are involved in the manifestation of the OA phenotype. OA-related pain management needs a multidisciplinary approach involving various treatment options including nonpharmacological and pharmacological ones. Due to the low number of high-quality studies related to OA related pain treatment, which conservative or non-conservative procedure should be chosen?

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Nutritional intervention in chronic pain: an innovative way of targeting central nervous system sensitization?

Cited by 40 publications

References 115 publications

Nociplastic Pain Criteria or Recognition of Central Sensitization? Pain Phenotyping in the Past, Present and Future

Nociplastic Pain Criteria or Recognition of Central Sensitization? Pain Phenotyping in the Past, Present and Future

Diet and Chronic Non-Cancer Pain: The State of the Art and Future Directions

Osteoarthritis Related Pain: Which Procedure is the Optimal Choice?

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