Nutritional iron status and susceptibility to <i>Proteus mirabilis</i> pyelonephritis in the rat

Hart, Robin C.; Kadis, Solomon; Chapman, Willie L.

doi:10.1139/m82-108

Cited by 23 publications

(13 citation statements)

References 10 publications

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“…However our results confirm those reported by other investigators for S. typhimurium (15) and other bacteria (7,9,20), showing increased resistance of hypoferremic animals to bacterial infection. Generally, protein malnutrition increases host susceptibility to infection as a result of the depression of nonspecific resistance factors and alteration of humoral and cellmediated immunity (6,13,14).…”

Section: Discussionsupporting

confidence: 93%

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Increased Resistance to Salmonella Infection of Hypoferremic Mice Fed a Low‐Protein Diet

Gauthier

Isoard

1986

Microbiology and Immunology

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Section: Discussionsupporting

confidence: 93%

“…Nevertheless other investigators have shown that laboratory animals fed an iron-deficient diet had decreased serum iron levels but increased resistance to various experimental infections (9,15). Such results are in agreement with the observation that lowering of the plasma iron content is a physiological reaction against infection (20).…”

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confidence: 99%

Increased Resistance to Salmonella Infection of Hypoferremic Mice Fed a Low‐Protein Diet

Gauthier

Isoard

1986

Microbiology and Immunology

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“…All P. vulgaris strains showed this haemolytic activity but at a significantly lower level than the P. mirabilis strains; it is a strongly cell-associated property (Peerbooms et al, 1983). The possible role of haemolysin production in the pathogenesis of urinary-tract infections could be the liberation of iron compounds (Waalwijk, MacLaren and De Graaf, 1983) stimulating bacterial growth in vivo (Hart, Kadis and Chapman, 1982), creation of favourable growth conditions by cell destruction or stimulation of cell invasiveness. This latter phenomenon we described earlier for P. mirabilis (Peerbooms et al, 1984).…”

Section: Discussionmentioning

confidence: 99%

Uropathogenic Properties of Proteus Mirabilis and Proteus Vulgaris

Peerbooms

Verweij

Maclaren

1985

Journal of Medical Microbiology

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SUMMARY. A group of faecal isolates of Proteus vulgaris and P. mirabilis was studied for the presence of possible virulence factors such as growth rates in urine and broth, haemolysin production, hydrophobicity, sensitivity to the bactericidal activity of human serum and cell invasiveness. Differences were found in haemolysin production, cell invasiveness and experimental virulence in a mouse model. These differences might explain why P. mirabilis is much more common in human urinary-tract infections than P. vulgaris. INTRODUCTIONProteus vulgaris and P. mirabilis are common inhabitants of the human gut; Krikler (1953) reported prevalences of 17% for P. mirabilis and 5% for P. vulgaris in the faeces of healthy persons. Urinary pathogens are thought to originate mainly from the gut and it is interesting that P. mirabilis is disproportionately more frequently isolated from patients with urinary-tract infections than P. vulgaris. Senior (1 979), for example, isolated 258 strains of P. mirabilis from infected urines against only four strains of P. vulgaris, two of which were isolated together with P. mirabilis. These epidemiological data suggest that P. mirabilis is more likely to cause urinary-tract infections than P. vulgaris. As both species are very similar, genetically and biochemically (Brenner et al., 1978), a comparative study of isolates of both species could yield valuable information about bacterial properties important in the pathogenesis of urinary-tract infections. Therefore, we have compared faecal isolates of both species, isolated from the same population, with regard to several properties: experimental virulence in a mouse model, growth rates in urine and broth, haemolysin production, hydrophobicity, sensitivity to the bactericidal activity of human serum, cell invasiveness and serotype. MATERIALS AND METHODSIsolation of Proteus strains from faeces. Stool samples were obtained from patients seen in general practice. Most samples had been submitted for examination for occult blood or for suspected parasitic infestation. A suspension of the sample in phosphate-buffered saline (PBS) was inoculated in the centre of a fresh nutrient-agar plate (Oxoid). The plates were incubated for ~ ~

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“…Proteins involved in iron acquisition are critical virulence factors produced during a UTI (9,42,45,457) and, potentially, CAUTIs, since this nutrient is limiting in urine (363). The addition of exogenous iron reduces the susceptibility of animals to the development of P. mirabilis pyelonephritis (131). While most enterobacteria produce phenolate (enterobactin)-and/or hydroxamine (aerobactin)-type siderophores during iron-limiting conditions (42,45,296), none of these traditional siderophores have been demonstrated to be produced in Proteus, Providencia, or Morganella species (92,296,323).…”

Section: Damage To the Host And Acquisition Of Nutrientsmentioning

confidence: 99%

Complicated Catheter-Associated Urinary Tract Infections Due toEscherichia coliandProteus mirabilis

et al. 2008

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SUMMARY Catheter-associated urinary tract infections (CAUTIs) represent the most common type of nosocomial infection and are a major health concern due to the complications and frequent recurrence. These infections are often caused by Escherichia coli and Proteus mirabilis. Gram-negative bacterial species that cause CAUTIs express a number of virulence factors associated with adhesion, motility, biofilm formation, immunoavoidance, and nutrient acquisition as well as factors that cause damage to the host. These infections can be reduced by limiting catheter usage and ensuring that health care professionals correctly use closed-system Foley catheters. A number of novel approaches such as condom and suprapubic catheters, intermittent catheterization, new surfaces, catheters with antimicrobial agents, and probiotics have thus far met with limited success. While the diagnosis of symptomatic versus asymptomatic CAUTIs may be a contentious issue, it is generally agreed that once a catheterized patient is believed to have a symptomatic urinary tract infection, the catheter is removed if possible due to the high rate of relapse. Research focusing on the pathogenesis of CAUTIs will lead to a better understanding of the disease process and will subsequently lead to the development of new diagnosis, prevention, and treatment options.

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Nutritional iron status and susceptibility to Proteus mirabilis pyelonephritis in the rat

Cited by 23 publications

References 10 publications

Increased Resistance to Salmonella Infection of Hypoferremic Mice Fed a Low‐Protein Diet

Increased Resistance to Salmonella Infection of Hypoferremic Mice Fed a Low‐Protein Diet

Uropathogenic Properties of Proteus Mirabilis and Proteus Vulgaris

Complicated Catheter-Associated Urinary Tract Infections Due toEscherichia coliandProteus mirabilis

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