Nutritional limitation in early postnatal life and its effect on aging and longevity in rodents

Davis, Kallie; Chamseddine, Douja; Harper, James M.

doi:10.1016/j.exger.2016.05.001

Cited by 12 publications

(9 citation statements)

References 113 publications

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“…Longer life expectancy in less provisioned neonates can be readily interpreted as a manifestation of caloric restriction - probably the most reliable environmental intervention extending lifespan across almost all animals studied (Fontana et al 2010; Kapahi et al 2017). There is a growing body of evidence that caloric restriction may extend longevity not only in organisms experiencing it continuously and throughout the lifespan, but also in organisms that experienced it early in life or even in parental germline (Brakefield et al 2005; Barnes & Ozanne 2011; Davis et al 2016). Lipids are the main storage nutrients in many crustaceans including Daphnia (Goulden & Place 1993; Smirnov 2017).…”

Section: Discussionmentioning

confidence: 99%

Inverse Lansing effect: maternal age and provisioning affecting daughters’ longevity and male offspring production

Anderson

Homa

Jonas-Closs

et al. 2021

Preprint

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Maternal age effects on life history of offspring has been demonstrated in a variety of organisms, more often than not offspring of older mothers having lower life expectancy (Lansing effect). However, there is no consensus on how general this phenomenon is and what are the genetic and epigenetic mechanisms behind it. We tested the predictions of Lansing effect in several Daphnia magna clones in and observed a significant genotype-by-maternal age interaction, indicating clone-specific magnitude and direction of the effect of maternal age on daughters' longevity. We then repeated this experiment with more detailed life-history and offspring provisioning data focusing on 2 clones with contrasting life-histories. One of these clones demonstrating the inverse Lansing effect, with daughters of older mothers living longer than those of young mothers. Individuals from a single-generation maternal age reversal treatment showed intermediate lifespan. We also report genotype-specific, ambidirectional, and largely fecundity-independent effects of maternal age on daughters' propensity to produce male offspring, with daughters of older mothers showing higher male production than daughters of younger mothers in the least male-producing clone and vise versa. We tested whether both effects can be explained by either lipid provisioning of embryos by mothers of different age, or by properties of mitochondria transmitted by mothers of different age to their offspring, using rhodamine-123 assay of mitochondrial membrane potential as a measure of mitochondria quality. We show that once lipid provisioning is accounted for, the effects of maternal age on lifespan and male production disappear and that the effect of lipid provisioning itself is clone-dependent, confirming that maternal provisioning sets daughters life history parameters. In the clone showing the inverse Lansing effect we demonstrated that, contrary to the predictions, neonates produced by older mothers were characterized by higher mitochondrial membrane potential in neural tissues than their counterparts born to younger mothers. We conclude that, in at least some genotypes, a reverse Lansing effect is possible, and hypothesize that it may be a result of lower lipid provisioning creating calorically restricted environment during embryonic development.

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Section: Discussionmentioning

confidence: 99%

Inverse Lansing effect: maternal age and provisioning affecting daughters’ longevity and male offspring production

Anderson

Homa

Jonas-Closs

et al. 2021

Preprint

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“…A large body of work in the field of aging has focused on how early-life interventions affect aging and longevity-for example, pre-and postnatal manipulation of caloric intake in various species (see, for example, [32]). For bird biologists, manipulation of the prenatal environment in ovo is an ongoing and intense area of study, due in large part to the relative ease of implementation and the separation of the developing embryo from more direct physiological maternal effects during development.…”

Section: Early-life Interventions and In Ovo Developmental Studiesmentioning

confidence: 99%

New Perspectives on Avian Models for Studies of Basic Aging Processes

Harper

Holmes

2021

Biomedicines

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Avian models have the potential to elucidate basic cellular and molecular mechanisms underlying the slow aging rates and exceptional longevity typical of this group of vertebrates. To date, most studies of avian aging have focused on relatively few of the phenomena now thought to be intrinsic to the aging process, but primarily on responses to oxidative stress and telomere dynamics. But a variety of whole-animal and cell-based approaches to avian aging and stress resistance have been developed—especially the use of primary cell lines and isolated erythrocytes—which permit other processes to be investigated. In this review, we highlight newer studies using these approaches. We also discuss recent research on age-related changes in neural function in birds in the context of sensory changes relevant to homing and navigation, as well as the maintenance of song. More recently, with the advent of “-omic” methodologies, including whole-genome studies, new approaches have gained momentum for investigating the mechanistic basis of aging in birds. Overall, current research suggests that birds exhibit an enhanced resistance to the detrimental effects of oxidative damage and maintain higher than expected levels of cellular function as they age. There is also evidence that genetic signatures associated with cellular defenses, as well as metabolic and immune function, are enhanced in birds but data are still lacking relative to that available from more conventional model organisms. We are optimistic that continued development of avian models in geroscience, especially under controlled laboratory conditions, will provide novel insights into the exceptional longevity of this animal taxon.

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“…71 Moderate early-life nutritional stress created in situations such as heavy competition for nursing or a low-protein maternal diet can produce a modest reduction in the growth of the pups but resistance to metabolic disease and increased life span in the adult animal, with glucocorticoid levels that were about 50% higher in the mature offspring of protein-restricted dams. 19,76 One report suggests that elevated corticosterone induced by long-term dietary restriction may be detrimental to learning but that this unfavorable effect is balanced by numerous protective mechanisms that are also induced by dietary restriction and that are reflected in improved long-term functional outcomes. 69 Some studies suggest that HPA activation is stronger in imposed as compared with voluntary weight loss.…”

Section: Examples Of Allostasis and Resiliencementioning

confidence: 99%

Analytic and Interpretational Pitfalls to Measuring Fecal Corticosterone Metabolites in Laboratory Rats and Mice

Rowland

Toth

2019

comp med

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Minimization and alleviation of stress are generally viewed as desirable aspects of laboratory animal management and use. However, achieving that goal requires an unambiguous and valid measure of stress. Glucocorticoid concentrations are commonly used as a physiologic index of stress. Measurement of glucocorticoids in blood, serum or plasma clearly reflects many types of both acute and chronic stress. However, the rapid rise in concentrations of circulating glucocorticoids that occurs even with relatively simple manipulations such as handling has led to the increased use of fecal glucocorticoid metabolite (FCM) assays, which provide a temporally integrated measure that may allow a more accurate interpretation of chronic stressors. In this review, we consider 3 aspects of glucocorticoids as a measure of stress. First, we discuss the analytic and interpretational pitfalls of using FCM concentrations as an index of stress in mice and rats. Second, we consider evidence that some degree of stress may benefit animals by priming physiologic and behavioral adaptations that render the animals more resilient in the face of stress. Finally, we use 2 situations—social housing and food restriction—to illustrate the concept of hormesis—a biologic phenomenon in which a low dose or intensity of a challenge has a beneficial effect, whereas exposure to high doses or intensities is detrimental.

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Nutritional limitation in early postnatal life and its effect on aging and longevity in rodents

Cited by 12 publications

References 113 publications

Inverse Lansing effect: maternal age and provisioning affecting daughters’ longevity and male offspring production

Inverse Lansing effect: maternal age and provisioning affecting daughters’ longevity and male offspring production

New Perspectives on Avian Models for Studies of Basic Aging Processes

Analytic and Interpretational Pitfalls to Measuring Fecal Corticosterone Metabolites in Laboratory Rats and Mice

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