Nutritional management of patients with diabetic peripheral neuropathy with L-methylfolate-methylcobalamin-pyridoxal-5-phosphate: results of a real-world patient experience trial

Abstract

In a real-world clinical setting, patients with diabetic peripheral neuropathy treated with LMF-MC-PP achieved significant improvements in total symptom score (NTSS-6) and in quality of life and functioning, together with greater medication satisfaction. A limitation of this study was the use of a survey instrument to collect data on patient outcomes.

A systematic review and meta‐analysis of nutrition interventions for chronic noncancer pain

“…After the removal of duplicates, a total of 7080 studies was identified in the search. Following full‐text screening, 71 studies were identified for inclusion, with 23 eligible for meta‐analysis. The abstracts for the majority of the papers were not sufficiently detailed to determine whether the full text should be retrieved.…”

“…Approximately 30% ( n = 21) of the studies were conducted in the USA , with five undertaken in Australia , four conducted in each of Germany , Japan and Spain , and three conducted in each of Denmark , Finland , Sweden , Iran and the Netherlands . Of the included studies, 47 were randomised controlled trials (RCT) , eight were nonrandomised trials , nine were pre–post studies , six were randomised cross‐over trials and one a longitudinal study .…”

“…Assessment of study quality rated 31 studies as of positive quality , 36 as neutral and four studies were classified as being of negative study quality . Of the 33 studies classified as neutral, information regarding the randomisation process ( n = 29) or the intervention description ( n = 13) was lacking.…”

“…The most common pain‐related condition experienced by study participants was rheumatoid arthritis ( n = 19 studies) , followed by osteoarthritis ( n = 16) and fibromyalgia ( n = 13) , migraine and chronic pain ( n = 4), joint pain , back pain , diabetic neuropathy ( n = 3), chronic pancreatitis , irritable bowel syndrome (IBS) , neuropathy and headache ( n = 1). Two studies had participants with two pain‐related conditions: rheumatoid arthritis and osteoarthritis and fibromyalgia and IBS .…”

Effects of Tongluotangtai recipe on serum pain substances 5-HT, B-EP, histamine and bradykinin in rats with painful diabetic peripheral neuropathy model of streptozotocin (STZ)

“…The clinical manifestations are spontaneous burning or lightning -like pain in lower abdomen, end of lower limbs, and lateral part of thigh. During onset, it will cause great pain, it is difficult to tolerate [3,4]. Therefore, finding DNP effective method can not only relieve pain of patients, also has an important significance in reducing disability and death rate induced by diabetes.…”