Nutritional modulation of mineralocorticoid and prostaglandin production: Potential role in prevention and treatment of gastric pathology

McCarty, Mark F.

doi:10.1016/0306-9877(83)90083-x

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…Aldosterone and relaxin pathways were concentrated in younger group, while growth hormone synthesis, secretion and action and thyroid hormone signaling pathway were concentrated in older group. Although there were many studies suggesting the relationship between these hormones and GC or other cancer, a lack of consensus existed regarding these hormones as a signi cant factor of pathogenesis mechanisms in younger female patients with GC, and further research was needed to explore their implications [32][33][34][35][36][37][38][39][40][41].…”

Section: Discussionmentioning

confidence: 99%

Molecular characteristics, potential mechanisms and prognostic gene model of younger female patients with gastric cancer

Luan,

Zhao,

Wang

et al. 2024

Preprint

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Background Male patients were twice as likely to develop gastric cancer (GC) compared to females, partly due to the protective effect of estrogen. However, the proportion of females increased in the young GC patients. The study was designed to explore comprehensive molecular profiles of younger female GC patients, as well as develop a prognostic gene model for female GC patients. Methods Gene expression and clinical data of GC and non-tumor patients were downloaded from the Gene Expression Omnibus (GEO) database. Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and gene set enrichment analysis (GSEA) were used to find molecular characteristics and potential mechanisms of younger female GC patients. The prognostic gene model containing 6 differential expressed genes (DEGs), which were between younger and older female patients, was established using Lasso-Cox regression. Its performance was validated by external validation. Then, receiver operating characteristic (ROC) curve was applied to determine the prognostic value of the prognostic gene model. Results Six GEO cohorts with 305 female GC patients (69 younger patients and 236 older patients) and 38 female non-tumor patients were included. A total of 4557 DEGs between female GC patients and non-tumor patients were identified, including 2212 up-regulated genes and 2345 down-regulated genes. Estrogen response early (p < 0.001) and estrogen response late (p < 0.001) were enriched in female GC patients. In KEGG analysis, aldosterone (p = 0.023) and relaxin pathways (p = 0.043) were concentrated in younger group. Moreover, we further used GSE84437 cohort to construct a prognostic gene model containing 6 genes, namely NREP, GAD1, SLCO4A1, KRT17, DEFB1, and P3H2, to predict the overall survival (OS) of female GC patients (AUC = 0.810). Younger female patients, who were related with high-risk at the genetic level, showed worse OS compared with older female patients who showed low-risk (HR = 5.7688, 95%CI: 3.0108–11.0530, P < 0.001). Conclusions In conclusion, we provided the comprehensive molecular profiles of younger female GC patients and found that there was a significant difference in enriched hormone-related pathways between younger group and older group. In addition, we found younger female patients showed worse OS compared with older female patients using the prognostic gene model we created.

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Section: Discussionmentioning

confidence: 99%

Molecular characteristics, potential mechanisms and prognostic gene model of younger female patients with gastric cancer

Luan,

Zhao,

Wang

et al. 2024

Preprint

View full text Add to dashboard Cite

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Hormonal status of gastric cancer. I. Effect of rice and salty rice diets on the constitution of urinary steroids in mice

Kodama

Ooki³

1987

Nutrition and Cancer

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We investigated the effect of rice and salty rice diets on the physical growth and on the constitution of urinary steroids in Swiss/ICR mice. The following three kinds of diets were employed in the feeding experiment: 1) standard diet; 2) rice diet; and 3) salty rice diet. Long-term maintenance of mice on both rice and salty rice diets led to a relative increase of tetrahydrocortisol associated with a concomitant decrease of androgen, progestin, and cholesterol in urine. Evidence was presented to indicate that the activity of endogenous hydrocortisone in mice could be augmented by an increased intake of sodium chloride alone; there was also evidence that the glandular stomach of a young mouse drinking physiological saline is highly sensitive to a suppressive action of hydrocortisone. We concluded that the two experimental diets produced a state of catabolic glucocorticoid excess combined with a deficiency of anabolic androgen and progestin. Mineralocorticoid status was not examined. In the salty rice diet, a markedly lower weight gain was observed, whereas in the rice diet, in general, no significant weight changes were observed.

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Hormonal status of gastric cancer. II. Abnormal constitution of urinary steroids in gastric cancer patients

Kodama

Kobayashi

et al. 1987

Nutrition and Cancer

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We undertook a case-control study regarding the excretions of 14 urinary steroids in gastric cancer (GC) patients. The results are as follows: the levels of androgens, progestins, and two corticosteroids were, relative to tetrahydrocortisol, significantly depressed in GC patients of both sexes compared with the corresponding normal controls. The deviation profile of urinary steroids was not affected by radical gastrectomy. Evidence indicated that observed changes of GC urines were the steroidal expression of a decrease of endogenous testosterone combined with an increase of endogenous hydrocortisone; there was also evidence that the hormonal environment of our GC patients was endocrinologically homologous to that of rice-fed or salty rice-fed mice. Epidemiological inquiry revealed that GC patients having more access to rice-rich or salt-rich diets were taller and less obese than were rural healthy controls. In agreement with the anthropometric data of those cancer patients is the finding that the specific death rate of GC (as calculated for each of 15 prefectures of northern Japan) was positively correlated for each sex with the mean heights, but not with the mean weights, of 14-year-old youths of those areas. This paper discusses the possible relevancy of the hormonal and epidemiological aspects of GC patients to gastrocarcinogenesis in light of steroid physiology.

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Nutritional modulation of mineralocorticoid and prostaglandin production: Potential role in prevention and treatment of gastric pathology

Cited by 3 publications

References 30 publications

Molecular characteristics, potential mechanisms and prognostic gene model of younger female patients with gastric cancer

Molecular characteristics, potential mechanisms and prognostic gene model of younger female patients with gastric cancer

Hormonal status of gastric cancer. I. Effect of rice and salty rice diets on the constitution of urinary steroids in mice

Hormonal status of gastric cancer. II. Abnormal constitution of urinary steroids in gastric cancer patients

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