Nutritional Modulation of the Carcinogenesis Process: Targets and Examples

Hursting, Stephen D.

doi:10.1159/000061822

Cited by 5 publications

(7 citation statements)

References 60 publications

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“…A recent case-control study of Asian-American women demonstrated a significant reduction in breast cancer risk associated with green tea consumption, especially in women with low soy intake (OR ¼ 0.45; 95% CI ¼ 0.26-0.78) [213]. Potential mechanisms by which green tea may protect against cancer development includes the scavenging of ROS, inhibition of carcinogen formation, enhanced carcinogen detoxification, enhanced DNA repair and modulation of estrogen metabolism [198,214]. Green tea has also been linked with cell cycle arrest and apoptosis [201,215].…”

Section: Green Teamentioning

confidence: 99%

Brief Report: Towards a dietary prevention of hereditary breast cancer

Kotsopoulos

Narod

2005

Cancer Causes Control

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Inheritance of a deleterious mutation in BRCA1 or BRCA2 confers a high lifetime risk of developing breast cancer. Variation in penetrance between individuals suggests that factors other than the gene mutation itself may influence the risk of cancer in susceptible women. Several risk factors have been identified which implicate estrogen-induced growth stimulation as a probable contributor to breast cancer pre-disposition. The protein products of both of these genes appear to help preserve genomic integrity via their participation in the DNA damage response and repair pathways. To date, the evidence for a cancer-protective role of dietary nutrients, for the most part those with antioxidant properties, has been based on women without any known genetic pre-disposition and it is important to identify and evaluate dietary factors which may modify the risk of cancer in BRCA carriers. Here we propose that diet modification may modulate the risk of hereditary breast cancer by decreasing DNA damage (possibly linked to estrogen exposure) or by enhancing DNA repair. The prevention of hereditary breast cancer through diet is an attractive complement to current management strategies and deserves exploration.

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Section: Green Teamentioning

confidence: 99%

Brief Report: Towards a dietary prevention of hereditary breast cancer

Kotsopoulos

Narod

2005

Cancer Causes Control

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“…Numerous bioactive substances seem to act as cancer-preventing agents by inhibiting the activation of pro-carcinogens, enhancing the detoxification of carcinogens or impeding the progression of carcinogenesis (Hursting et al, 1999;Wattenberg, 1992). Chronic lymphocytic leukaemia (CLL) is the commonest form of leukaemia in Western World and is considered a disease of B-cell in which a faulty apoptotic mechanism is still retained one of the primary pathogenic events (Chiorazzi et al, 2005;Reed & Kitada, 2001).…”

Section: Introductionmentioning

confidence: 99%

Active caspase-3 detection to evaluate apoptosis induced by Verbena officinalis essential oil and citral in chronic lymphocytic leukaemia cells

Martino¹,

Arena²,

Minervini³

et al. 2011

Rev. bras. farmacogn.

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Verbena officinalis L., Verbenaceae, commonly known as vervain, is a plant widely used in medicine. Despite of its widespread use in different traditional practices, the mechanisms of pharmacological actions of the plant and its volatile oil are still unclear. We evaluated the pro-apoptotic activity of V. officinalis essential oil and of its main component, citral, on lymphocytes collected from ten patients with chronic lymphocytic leukaemia (CLL), a disease in which a faulty apoptotic mechanism is still retained one of the primary pathogenic events, by adding to treated mononuclear cells, annexin-V, propidium iodide, and CD19. Apoptosis was also evaluated using anti-active-caspase-3 monoclonal antibody after permeabilization of the cells. Both V. officinalis essential oil and citral were found able to induce apoptosis in CLL cells and to activate caspase-3, which is considered the way by means they active apoptosis in B neoplastic cells. This data further support evidences that indicate natural compounds as possible lead structure to develop new therapeutic agents for CLL.

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“…Numerous bioactive constituents have been hypothesized to act as cancerpreventing agents by inhibiting the activation of procarcinogens, enhancing the detoxifi cation of carcinogens, preventing them from interacting with critical target sites or stopping the progression of carcinogenesis (Wattenberg, 1990(Wattenberg, , 1992Hursting et al, 1999). Plants, vegetables, and herbs used as folk and traditional medicines have been currently accepted as one of the main sources of cancer chemopreventive agents in drug discovery and development (Abdullaev et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Effect of the Method of Preparation on the Composition and Cytotoxic Activity of the Essential Oil of Pituranthos tortuosus

Abdallah

Ezzat

2011

Zeitschrift Für Naturforschung C

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The aerial parts of Pituranthos tortuosus (Desf.) Benth and Hook (Apiaceae), growing wild in Egypt, yielded 0.8%, 0.6%, and 1.5% (v/w) of essential oil when prepared by hydrodistillation (HD), simultaneous hydrodistillation-solvent (n-pentane) extraction (Lickens-Nickerson, DE), and conventional volatile solvent extraction (preparation of the "absolute", SE), respectively. GC-MS analysis showed that the major components in the HD sample were β-myrcene (18.81%), sabinene (18.49%), trans-iso-elemicin (12.90%), and terpinen-4-ol (8.09%); those predominent in the DE sample were terpinen-4-ol (29.65%), sabinene (7.38%), γ-terpinene (7.27%), and β-myrcene (5.53%); while the prominent ones in the SE sample were terpinen-4-ol (15.40%), dill apiol (7.90%), and allo-ocimene (4E,6Z) (6.00%). The oil prepared in each case was tested for its cytotoxic activity on three human cancer cell lines, i.e. liver cancer cell line (HEPG2), colon cancer cell line (HCT116), and breast cancer cell line (MCF7). The DE sample showed the most potent activity against the three human cancer cell lines (with IC 50 values of 1.67, 1.34, and 3.38 μg/ml against the liver, colon, and breast cancer cell lines, respectively). Terpinen-4-ol, sabinene, γ-terpinene, and β-myrcene were isolated from the DE sample and subjected to a similar evaluation of cytotoxic potency; signifi cant activity was observed.

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Nutritional Modulation of the Carcinogenesis Process: Targets and Examples

Cited by 5 publications

References 60 publications

Brief Report: Towards a dietary prevention of hereditary breast cancer

Brief Report: Towards a dietary prevention of hereditary breast cancer

Active caspase-3 detection to evaluate apoptosis induced by Verbena officinalis essential oil and citral in chronic lymphocytic leukaemia cells

Effect of the Method of Preparation on the Composition and Cytotoxic Activity of the Essential Oil of Pituranthos tortuosus

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