Nutritional parameters affecting erythrocyte polyamine levels in cancer patients.

Ota, David M.; Nishioka, Kusuki; Foulkes, Mary A.; Grossie, V. Bruce

doi:10.1200/jco.1984.2.10.1157

Cited by 31 publications

(12 citation statements)

References 15 publications

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“…Therefore, it is possible that urinary excretion of polyamines is significantly related to liver metabolism, with a more advanced functional influence of this phenomenon in cancer patients depending on either elevated hepatic acute-phase reactions with increased liver protein synthesis (26), or a more advanced influence of cholestasis in many cancer patients with progressive disease. This interpretation has also support in a negative correlation between plasma albumin, a negative acute-phase reactant, and polyamine excretion in both the present and previous studies (27).…”

Section: Discussionsupporting

confidence: 75%

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Increased Urinary Polyamine Excretion in Unselected Cancer Patients Related to Host Factors

et al. 1998

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Unselected patients with solid malignant tumours were investigated in order to determine whether they displayed elevated urinary excretion of polyamines; and if so, whether polyamine excretion in such patients predicts disease progression, or is secondary to host and systemic factors. Thirty-eight male and female patients with generalized solid, mainly gastrointestinal, malignant tumours were investigated. Ten male patients operated on for infrarenal aortic aneurysms and 15 otherwise healthy male and female patients hospitalized for minor surgical procedures served as reference patients, representing individuals with and without metabolic stress. Urine samples were collected from all patients during 24 h for measurement of both total and individual excretion of polyamines during three consecutive days. Polyamine excretion was not significantly increased in cancer patients when compared by analysis of variance among the three patient groups. However, polyamine excretion was significantly elevated in both cancer and stressed, non-cancer patients compared with patients without stress (p < 0.05). A multivariate analysis indicated that plasma protein and albumin concentrations, abnormal liver function tests and liver metastasis predicted variation in polyamine excretion in cancer patients (p < 0.01), but this was unrelated to survival. Our results demonstrate that increased polyamine excretion in cancer patients is related more to host factors than to tumour growth itself.

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Section: Discussionsupporting

confidence: 75%

“…Previous studies have demonstrated high polyamine content in erythrocytes, indicating that changes in plasma concentration of red blood cells may relate to whole-body polyamine content (27). Anaemia is a strong promoter of cell proliferation in bone marrow and of the synthesis of growth factors such as erythropoietin.…”

Section: Discussionmentioning

confidence: 99%

Increased Urinary Polyamine Excretion in Unselected Cancer Patients Related to Host Factors

et al. 1998

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“…This conclusion was also supported by the finding that the carbohydrate component in ordinary animal food pellets was a powerful stimulant of tumour cell proliferation by activating DNA synthesis, an effect which may be evoked by insulin (Westin et al, 1991a;Westin et al, 1991b). Changes in tumour DNA synthesis was reflected by alterations in ornithinedecarboxylase activity (ODC), which is rate limiting for polyamine synthesis (Russel, 1973;Pegg, 1988;Ota et al, 1984;Janne et al, 1978). Polyamines are probably endogenously produced growth factors, that without cell DNA synthesis and cellcycle traverse cannot proceed normally.…”

supporting

confidence: 49%

Energetics of nutrition and polyamine-related tumour growth alterations in experimental cancer

Westin

Soussi²,

Idström³

et al. 1993

Br J Cancer

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Summary The aim of this study was to evaluate whether food intake modulates experimental tumour growth by acute alterations in the energy state and blood flow of the tumour, and if so whether such changes are related to alterations in the enzyme ornithinedecarboxylase (ODC) and DNA synthesis. Inbred mice (C57BL/ J) bearing a syngeneic undifferentiated and rapidly growing tumour were used. The tumour levels of high energy phosphates were measured in vivo by 31-P-NMR spectroscopy and biochemically following tissue extraction. DNA synthesis was estimated by measuring the incorporation of bromodeoxy-uridine into tumour DNA. Difluoro-methylornithine (DFMO) was used to inhibit ODC-activity. Tumour

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“…This observation may be related to a possible increase in tumor growth in patients given TPN treatment for cancer-related cachexia (Ota et al, 1984), where TPN increased RBC polyamines selectively in cancer patients but not in non-cancer patients.…”

Section: ; Mccannmentioning

confidence: 96%

Polyamine‐directed preferential nutritional repletion of normal tissues in tumor‐bearing hosts

Nishioka

Grossie

Ajani

et al. 1988

Intl Journal of Cancer

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Our previous study demonstrated that total parenteral nutrition (TPN) increases erythrocyte (RBC) polyamines selectively in cancer patients but not in non-cancer patients, suggesting that these changes may relate to tumor presence. We therefore studied the possible relationship between RBC polyamine levels and potential tumor growth induced by TPN. In addition, we attempted to control tumor growth during TPN with alpha-difluoromethylornithine (DFMO), a suicide inhibitor of ornithine decarboxylase (ODC), in a fibrosarcoma-bearing rat model. Rats in a control group received chow ad libitum for 3 weeks and their tumors grew exponentially. A restricted intake (RI) tumor-bearing group received 8 g chow per day per rat; this produced malnourished rats in which tumor growth significantly slowed. The third group (RI----TPN) received the RI diet for 2 weeks and TPN for 1 week, which resulted in an increase in tumor growth. The last group (RI----TPN + DFMO) received a 2-week RI regimen and 1-week TPN plus DFMO regimen, which inhibited tumor growth to the level of the RI group due to the addition of DFMO (1 g/kg/day). Although the addition of TPN to the RI regimen markedly increased tumor ODC activity, as well as tumor putrescine and RBC putrescine levels, the addition of DFMO to the RI----TPN regimen entirely abolished these increases. Despite DFMO treatment, liver ODC activity in RI----TPN + DFMO group was unaffected. The plasma albumin level, an indicator of host nutrition, of the RI----TPN + DFMO group was significantly higher than that of the RI group. Liver, spleen, kidney and total body weights of the RI----TPN or RI----TPN + DFMO group were significantly higher than those of the RI group. These results indicate that TPN can enhance tumor growth in malnourished hosts and that the addition of DFMO to TPN can effectively control this TPN-enhanced tumor growth, leading to preferential nutritional repletion of the host.

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Nutritional parameters affecting erythrocyte polyamine levels in cancer patients.

Cited by 31 publications

References 15 publications

Increased Urinary Polyamine Excretion in Unselected Cancer Patients Related to Host Factors

Increased Urinary Polyamine Excretion in Unselected Cancer Patients Related to Host Factors

Energetics of nutrition and polyamine-related tumour growth alterations in experimental cancer

Polyamine‐directed preferential nutritional repletion of normal tissues in tumor‐bearing hosts

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