Nutritional profile of pediatric cancer patients at Cancer Institute, Chennai

Radhakrishnan, Venkatraman; Ganesan, Prasanth; Rajendranath, Rejiv; Ganesan, T.; Sagar, TG

doi:10.4103/0019-509x.175841

Cited by 18 publications

(20 citation statements)

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“…Nutritional status starts to deteriorate rapidly after treatment begins and malnutrition continues to be a problem underlining the need to develop efficient methods to provide nutritional support for children with cancer 35 . Two studies reported improvement in nutritional status of the patients during the course of treatment attributed to active nutritional interventions 36,37 …”

Section: Discussionmentioning

confidence: 99%

“…35 Two studies reported improvement in nutritional status of the patients during the course of treatment attributed to active nutritional interventions. 36,37 The value of serum albumin and prealbumin for diagnosing or monitoring malnutrition is controversial considering their relatively low specificity and the effects of acute illnesses, especially inflammatory states. [38][39][40] A systematic review reported that serum visceral proteins are not predictive of nutritional deprivation in starved and otherwise healthy malnourished people.…”

Section: F I G U R Ementioning

confidence: 99%

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Assessment of nutritional status in children with cancer: Significance of arm anthropometry and serum visceral proteins

Yaprak

Yalçın

Pınar

et al. 2020

Pediatric Blood & Cancer

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Section: Discussionmentioning

confidence: 99%

Section: F I G U R Ementioning

confidence: 99%

Assessment of nutritional status in children with cancer: Significance of arm anthropometry and serum visceral proteins

Yaprak

Yalçın

Pınar

et al. 2020

Pediatric Blood & Cancer

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“… 26 Malnutrition is a significant problem in developing countries, and it has been associated with poor outcomes in pediatric malignancies, but it was not a significant prognostic factor in this study. 27 …”

Section: Discussionmentioning

confidence: 99%

Pediatric Hodgkin Lymphoma Treated at Cancer Institute, Chennai, India: Long-Term Outcome

Radhakrishnan

Dhanushkodi

Ganesan

et al. 2017

JGO

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PurposePediatric Hodgkin lymphoma (HL) is a highly curable malignancy. Outcomes for pediatric HL may vary between developed and developing countries for multiple reasons. This study was conducted to ascertain the outcomes of children with HL at our center and to identify risk factors for recurrent disease.MethodsWe analyzed the outcomes of 172 consecutive, previously untreated patients with pediatric HL presenting at our center from 2001 to 2010. Patients were treated with either adriamycin, bleomycin, vinblastine, and dacarbazine or adriamycin, bleomycin, vinblastine, cyclophosphamide, vincristine, prednisone, and procarbazine chemotherapy initially, and radiation to bulky sites or a single site of residual disease when appropriate.ResultsThe median duration of follow-up was 77 months. The median age of the patients was 10 years; 127 (74%) of the 172 patients were male. The extent of disease was stage I and II in 59% of the patients. B symptoms were present in 32% of the patients, and 27% had bulky disease. The most common histologic subtype was mixed cellularity (45%). The 5-year overall survival (OS) and progression-free survival (PFS) of the entire cohort were 92.9% and 83.1%, respectively. The 5-year OS rates for patients with stage I, II, III, and IV were 96%, 94.7%, 84%, and 69.8%, respectively. On univariate analysis, advanced stage, response on interim radiologic assessment, and presence of B symptoms significantly predicted inferior PFS and OS. On multivariate analysis, only interim radiologic response significantly predicted PFS (P < .001) and OS (P < .001).ConclusionOverall, the outcomes of patients treated at our center are comparable to those observed in other centers in India and globally.

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“…The prevalence of undernutrition in children with cancer varies between 10% and 60%, depending on the criteria and assessment of undernutrition, types and stages of malignancy, the time of assessment during anti-tumor treatment, and the socioeconomic status of the examined patient subset [8,9]. Higher prevalence data of undernutrition have been published from low-GDP countries, where even most healthy children are undernourished [8,10]. In contrast, undernutrition is less frequent and oncological treatment outcome measures are better in high-GDP countries [8,9,11].…”

Section: Introductionmentioning

confidence: 99%

“…Higher prevalence data of undernutrition have been published from low-GDP countries, where even most healthy children are undernourished [8,10]. In contrast, undernutrition is less frequent and oncological treatment outcome measures are better in high-GDP countries [8,9,11]. The nutritional status of Hungarian children with malignancies has not yet been determined.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Undernutrition and Effect of Body Weight Loss on Survival among Pediatric Cancer Patients in Northeastern Hungary

Kadenczki

Nagy

Kiss

2021

IJERPH

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Undernutrition is a prevalent condition in pediatric malignancy patients leading to unfavorable outcomes. The aim of this retrospective study was to determine the nutritional status and rate of undernutrition in 174 Hungarian pediatric patients with malignancies and the impact on 5-year survival based on anthropometric measurements. At the time of diagnosis, 5.0%, 4.6%, and 4.0% of patients were undernourished as determined by body weight (BW), weight-for-height (WFH), and body mass index (BMI) Z-score, respectively. The rate of undernutrition was 30.5% using ideal body weight percent (IBW%). Undernutrition at the time of diagnosis worsened the five-year overall survival only in solid tumor patients as defined by BMI Z-score and IBW%. Furthermore, 26.5% of patients became undernourished based on IBW% during the treatment period. Deterioration of nutritional status during treatment unfavorably influenced overall survival in both hematological and solid tumor subsets. Abnormal BW, WFH, and BMI Z-score were associated with poor prognosis in the hematologic group. The mortality risk was higher among hematologic patients with weight loss exceeding 20%. In conclusion, IBW% seems to be the most sensitive parameter to estimate undernutrition. Furthermore, BMI Z-score in both groups and severe weight loss in the hematological group may influence clinical outcome and play a role in prognosis assessment.

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Nutritional profile of pediatric cancer patients at Cancer Institute, Chennai

Abstract: Under-nutrition is present in close to half of the pediatric cancer patients presenting to our institute. Active nutritional intervention and education were able to significantly reduce the prevalence of under-nutrition in patients at the end of treatment.

Cited by 18 publications

References 1 publication

Assessment of nutritional status in children with cancer: Significance of arm anthropometry and serum visceral proteins

Assessment of nutritional status in children with cancer: Significance of arm anthropometry and serum visceral proteins

Pediatric Hodgkin Lymphoma Treated at Cancer Institute, Chennai, India: Long-Term Outcome

Prevalence of Undernutrition and Effect of Body Weight Loss on Survival among Pediatric Cancer Patients in Northeastern Hungary

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