2010
DOI: 10.1017/s0954422410000077
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Nutritional programming of gastrointestinal tract development. Is the pig a good model for man?

Abstract: The consequences of early-life nutritional programming in man and other mammalian species have been studied chiefly at the metabolic level. Very few studies, if any, have been performed in the gastrointestinal tract (GIT) as the target organ, but extensive GIT studies are needed since the GIT plays a key role in nutrient supply and has an impact on functions of the entire organism. The possible deleterious effects of nutritional programming at the metabolic level were discovered following epidemiological studi… Show more

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Cited by 270 publications
(234 citation statements)
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References 179 publications
(205 reference statements)
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“…In a recent review, Guilloteau et al (28) highlighted the numerous similarities (anatomy, physiology, digestion, absorption and metabolism) between the gastrointestinal tract of humans and pigs. More specifically for vitamin B 12 , the bioavailability of dietary * Values for unsupplemented did not differ from those of cyanocobalamin (P¼0·76), cyanocobalamin differed from those of all milks (raw, pasteurised and microfiltrated; P¼0·001), raw milk did not differ from those of treated (pasteurised þ microfiltrated) milks (P¼0·83) and pasteurised milk did not differ from those of microfiltrated milk (P¼0·45).…”
Section: Discussionmentioning
confidence: 99%
“…In a recent review, Guilloteau et al (28) highlighted the numerous similarities (anatomy, physiology, digestion, absorption and metabolism) between the gastrointestinal tract of humans and pigs. More specifically for vitamin B 12 , the bioavailability of dietary * Values for unsupplemented did not differ from those of cyanocobalamin (P¼0·76), cyanocobalamin differed from those of all milks (raw, pasteurised and microfiltrated; P¼0·001), raw milk did not differ from those of treated (pasteurised þ microfiltrated) milks (P¼0·83) and pasteurised milk did not differ from those of microfiltrated milk (P¼0·45).…”
Section: Discussionmentioning
confidence: 99%
“…Early-life nutrition may also influence gut immunity and metabolism at long-term and may impact growth of pigs at later physiological stages by imprinting [1]. Indeed, modulating the diet of females during gestation and lactation and/or the diet of young animal's results in later change in microbiota and epigenetic reactions in several species [2].…”
Section: Introductionmentioning
confidence: 99%
“…Pigs seem to be the most appropriate, if not the best, animal model for human nutrition studies after non-human primates, simply because there are remarkable similarities between pigs and humans with respect to their nutritional requirements, as well as their digestive and metabolic processes [16][17][18]. The findings from this research project on pigs may also provide some novel insights into the molecular mechanisms of muscle growth vs. wasting in humans.…”
Section: Introductionmentioning
confidence: 91%