Nutritional regulation of gene expression of insulin-like growth factor-binding proteins and the acid-labile subunit in various tissues of rats

Takenaka, Asako; Mori, Masao; Yamada, Shotaro; Ohgane, Jun; Takahashi, Shin‐Ichiro; Noguchi, Tadashi

doi:10.1677/joe.0.1500033

Cited by 56 publications

(19 citation statements)

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“…A similar discrepancy was reported where protein restriction reduced plasma IGFBP-3 and -4 levels, but liver mRNA levels did not change (4). This discordance between changes in protein and mRNA concentrations could be due to undernutrition increasing IGFBP clearance or protease activity (6).…”

Section: Discussionsupporting

confidence: 65%

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Interaction between malnutrition and ovarian hormones on the systemic IGF-I axis

Goya

García‐Segura²,

Ramos³

et al. 2002

European Journal of Endocrinology

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Objective: In malnutrition both the GH -IGF and reproductive axes are greatly affected. Because the actions of IGF and sex steroids are inter-dependent in many tissues, we have examined how ovariectomy modulates the response of the systemic IGF system to undernutrition. Design and methods: Peripubertal (30 days of age) female rats were either sham operated or ovariectomized. Five days later half of each group was submitted to a protein-caloric restriction diet. All rats were killed at 60 days of age. Results: Growth was decreased in all rats submitted to calorie restriction and this was consistent with a decrease in circulating IGF-I concentrations and liver IGF-I mRNA expression. While in normally fed rats ovariectomy had no significant effect on serum IGF-I concentrations, ovariectomized and underfed rats had significantly higher levels than intact underfed rats. In undernourished rats, serum IGF-binding proteins (IGFBP)-1, -2 and -3 concentrations were significantly reduced and this was not modified by ovariectomy. In contrast, liver mRNA concentrations of IGFBP-1 and -2 were increased and IGFBP-3 unchanged in intact undernourished animals, suggesting that undernutrition could be affecting the proteolysis of these binding proteins, and this response was significantly modulated by ovariectomy. Conclusion: These results indicate that the presence of circulating ovarian hormones significantly affects the response of the IGF system to undernutrition.

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Section: Discussionsupporting

confidence: 65%

“…Therefore, their response to later hormonal manipulations may differ from that of adult animals. This may also explain why we found no effect of ovariectomy on serum IGFBP-1, -2 or -3 concentrations, while other authors report changes (4,41).…”

Section: Discussionmentioning

confidence: 41%

Interaction between malnutrition and ovarian hormones on the systemic IGF-I axis

Goya

García‐Segura²,

Ramos³

et al. 2002

European Journal of Endocrinology

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“…The 23 kDa IGFBP, which we presume to be BP4, was depressed at most ages by fasting. BP4 impedes IGF action in culture systems (McCusker 1998) and is reduced by poor nutrition (Holt et al 1996, Takenaka et al 1996. Reduction of BP4, in conjunction with changes in clearance and/or secretion of IGF, seems to be an appropriate response if basal metabolic functions of IGFs are to be maintained in the face of nutritional stress.…”

Section: Discussionmentioning

confidence: 99%

Nutritional regulation of IGF-II, but not IGF-I, is age dependent in sheep

Oldham

Martyn²,

Hua³

et al. 1999

Journal of Endocrinology

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In post-natal animals, plasma concentrations of IGF-I are tightly regulated by nutritional status. The current study reports that plasma levels of IGF-II in sheep are also regulated by nutrition, but whether plasma IGF-II is increased, decreased or remains the same, depends on the age of the animal. Ewe lambs, ranging in age from 2 days to 2 years, were fed or fasted for lengths of time between 24 and 72 h. Blood samples were taken at intervals of 24 h throughout the treatment period and immediately before slaughter.Plasma concentrations of IGF-I increased with advancing age in fed animals (P<0·001) and were reduced by fasting in all age groups (P<0·001). Plasma concentrations of IGF-II also increased as animals matured (P<0·001), but did not show an overall effect of the fasting treatment. An interaction between age and nutrition (P<0·001) resulted from a decrease in plasma IGF-II in response to fasting in neonatal animals (P<0·01) and, conversely, increased levels of plasma IGF-II in fasted mature animals (P<0·01 or P<0·001). Fasted sheep of peripubertal age showed no change in plasma levels of IGF-II.The nutritional sensitivity of serum IGF-binding proteins (BPs) also changed with age. The 29 kDa BP, which we presume to be BP1, was elevated by fasting in young animals and reduced slightly in older animals. BP2 was increased to a similar magnitude by fasting at all ages. BP3 was depressed by fasting in young animals and showed little change in adults. In contrast, a 24 kDa BP, which is probably BP4, showed little change in young animals and was reduced substantially in older sheep.In conclusion, the response of plasma IGF-II to fasting suggests that this peptide has functions in mediating nutritional stress which depend on the age of the animal, and also that the role of IGF-II may differ from that of IGF-I in adults.

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“…In rats it is associated with lower serum IGF-I concentrations, partly because of increased IGF-I hepatic mRNA fragility (Straus & Takemoto 1990) and altered serum IGFBP profiles (increased IGFBPs-1 and -2, decreased IGFBPs-3 and -4) reflecting hepatic mRNA transcription (Lemozy et al 1994, Takenaka et al 1996. In carnivores, protein may be more important than energy in modulation of IGF and IGFBP concentrations, as it is in GH secretion.…”

Section: Discussionmentioning

confidence: 99%

Nutritional modulation of canine insulin-like growth factors and their binding proteins

Maxwell¹,

Butterwick²,

Yateman³

et al. 1998

Journal of Endocrinology

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The response of canine insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) to moderate nutritional restriction followed by refeeding has not previously been studied in detail. The purpose of these studies was to examine the effects of nutritional restriction on the IGF system of adult dogs. Normal serum IGF values were established after validation of heterologous RIAs for measuring canine IGFs-I and -II. Canine serum IGFBP profiles were examined by Western ligand blotting (WLB), using radiolabelled recombinant human (rh) IGF-I as the ligand, and were found to be similar to those of other species. IGF-I and IGFBP-3 concentrations correlated with body weight, thus reflecting breed size as previously shown, whereas IGF-II concentrations did not.IGFBP-2 serum concentrations and band intensity on WLB were increased compared with normal human serum IGFBP-2. Overnight fasting had no effect on IGF or IGFBP concentrations, including IGFBP-1, nor did refeeding. Prolonged restriction to 56% and then 42·5% of maintenance energy requirements for 2 weeks decreased IGF-I concentrations by 20·4% and 32·7% respectively. Feeding of the same diet ad libitum for 2 weeks normalised IGF-I concentrations. There were no changes in IGF-II or insulin levels. Serum IGFBP-2 concentrations increased with 56% restriction of maintenance energy (P=0·03). We conclude that serum IGF-I is potentially a useful marker of short-term change in nutritional status in the adult dog.

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Nutritional regulation of gene expression of insulin-like growth factor-binding proteins and the acid-labile subunit in various tissues of rats

Cited by 56 publications

References 0 publications

Interaction between malnutrition and ovarian hormones on the systemic IGF-I axis

Interaction between malnutrition and ovarian hormones on the systemic IGF-I axis

Nutritional regulation of IGF-II, but not IGF-I, is age dependent in sheep

Nutritional modulation of canine insulin-like growth factors and their binding proteins

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