Nutritional Requirements during the Latter Half of Life

143

Male and female Wistar rats (n = 140) age 1.5 months were maintained in either wheel-cage units or cage units for their entire life span. Voluntary wheel exercise significantly increased the mean longevity of both male and female rats compared with that of control rats. Between and within groups, growth duration was positively related to longevity, and growth rate was negatively related to longevity. These factors may explain differences in longevity between exercise and control groups and differences in longevity between male and female groups. These factors of growth, here defined in terms of body weight increment, may possibly account for many instances of group differences in longevity

Section: Discussionsupporting

confidence: 78%

mentioning

confidence: 99%

See 1 more Smart Citation

Effects of Long-Term Voluntary Wheel Exercise on Male and Female Wistar Rats

Goodrick¹

1980

143

“…As an average, the females lived 163 days longer (850 vs. 687) or 24% longer than the males. This is in line with previous studies (Slonaker, 1912;McCay et al, 1941McCay et al, , 1943Sperling et al, 1955). In each comparison, the rats which had the opportunity to exercise outlived their mates that were housed in standard indi vidual cages.…”

Section: Life Spansupporting

confidence: 89%

Effect of Sulfamerazine and Exercise on Life Span of Rats and Hamsters

Sperling¹,

Loosli²,

Lupien³

et al. 1978

Rats and hamsters of both sexes were divided into exercise and non-exercise groups with and without small amounts of sulfamerazine in the diet. In every case rats on exercise lived longer than their controls. The females outlived the males while hamster males lived slightly longer than females. Sulfamerazine had a significantly beneficial effect on life span of rats and apparently increased that of male hamsters. All rats fed sulfamerazine attained higher maximum weights than their controls. There was no consistent change in bone densities.

“…1947]; dietary protein intake [Goodrick, 1978;Leto et al, 1976;Miller and Payne. 1968;Nakagawa and Masana, 1971;Ross, 1959;Stoltzner, 1977]; feeding sched ule [Carlson and Hoelzel, 1946;GerbaseDcLima et al, 1975]; and exercise [Droh and Folman, 1976;Goodrick, 1978;McCay et al, 1941;Retzlaff et al, 1966], In addition, the relationship of genetic variables, such as sex and strain, to growth rate and longevity has also been of interest [cf. Comfort.…”

mentioning

confidence: 99%

Relationship of Sex, Exercise, and Growth Rate to Life Span in the Wistar Rat: a Multivariate Correlational Approach

Ingram¹,

Reynolds²,

Goodrick³

1982

Measures of body weight change were calculated and examined in relation to the life span of 68 male and 71 female Wistar rats that were maintained either in wheel-cage units or cages without wheels. The analysis revealed the following: (a) sex and wheel exercise accounted for nearly one third of the obtained variation in life span; (b) growth rate, defined as the ratio of peak body weight to growth duration, accounted for over 15% of the variance in life span unattributable to sex and exercise; (c) measures of body weight gain early in the developmental span were virtually unrelated to life span; (d) beyond 9 months of age, measures of body weight gain showed a significant positive relationship with life span. Thus, there was no evidence of a negative relationship between life span and body weight gain during early life.