Nutritional risk index predicts the prognosis of gastric cancer patients with pyloric stenosis who received preoperative parenteral nutrition

Li, Guomiao; He, Lijuan; Sun, Hao

doi:10.3892/ol.2023.13988

Cited by 3 publications

(1 citation statement)

References 45 publications

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“…Gastric cancer complicated by gastric outlet obstruction has long been a focus of researchers. In 2023, Li et al ( 27 ) conducted comparative analysis to investigate the unique clinical and pathological characteristics of patients with gastric outlet obstruction. Data were collected from 194 patients with gastric cancer accompanied by gastric outlet obstruction and 221 patients without gastric outlet obstruction.…”

Section: Discussionmentioning

confidence: 99%

Effect of different preoperative nutritional treatments on postoperative recovery and clinical outcomes in patients with gastric cancer and early gastric outlet obstruction

Wang,

Yang

2024

Oncol Lett

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Patients with gastric cancer and early gastric outlet obstruction often experience malnutrition and require various nutritional support strategies. This study aimed to evaluate the impact of different preoperative nutritional treatments on their postoperative recovery and prognosis. The present retrospective study collected data from 467 patients with gastric cancer and early gastric outlet obstruction who underwent surgery at Harbin Medical University Cancer Hospital (Harbin, China) between January 2016 and December 2018. All patients received preoperative nutritional treatment, with a mean treatment duration of 8.23±2.33 days. The present study analyzed associations and survival in different groups using χ 2 , independent-samples t-test, ANOVA and log-rank tests. Furthermore, single- and multi-factor survival analyses were conducted and nomograms and calibration curves constructed to investigate factors influencing patient survival. In this study, 230 patients (49.3%) received only parenteral nutrition (PN; Group 1), 162 patients (34.7%) received PN combined with enteral nutrition (EN; Group 2) and 75 patients (16.0%) received PN combined with a full- or semi-liquid diet (Group 3). No significant differences in clinical and pathological parameters were observed among the groups. However, Group 2 showed significant advantages in postoperative recovery, including faster time to first postoperative bowel sounds, flatus and bowel movement. Survival analysis indicated that Group 3 had shorter progression-free survival (χ 2 =30.485) and overall survival (χ 2 =31.249). Preoperative nutritional treatment was identified as an independent prognostic factor. Preoperative PN combined with EN proved advantageous for postoperative recovery of patients with gastric cancer and early gastric outlet obstruction. Furthermore, PN combined with full- or semi-liquid diets may not have fully met the nutritional needs of these patients, resulting in less favorable clinical outcomes.

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Section: Discussionmentioning

confidence: 99%

Effect of different preoperative nutritional treatments on postoperative recovery and clinical outcomes in patients with gastric cancer and early gastric outlet obstruction

Wang,

Yang

2024

Oncol Lett

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The use of clinical and biochemical tools of nutritional status assessment in predicting the course of liver cirrhosis

PENTIUK,

MOTSIUK,

PENTIUK

et al. 2023

Eksp.Klin.fiziol.biohim

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Malnutrition is a common complication of liver cirrhosis (LC) and is associated with a poor prognosis. Optimal tools for monitoring the nutritional status in LC have not been determined. The aim of the work was to evaluate the diagnostic agreement and prognostic value of the Nutritional Risk Index (NRI) and the Controlling Nutritional Status (CONtrolling NUTritional status, CONUT) score in LC patients. Materials and methods. 161 LC patients (mean age 55.2 ± 11.6 years) were included. 23 patients had LC class A, 57 – class B, and 81 – CTP class C. During the follow-up period (median 489 (interquartile range 293–639) days), 50 patients died of LC complications. The nutritional status of patients was assessed according to the CONUT score and the NRI. The results. Moderate and severe malnutrition was found in 95 and 83 % of class C LC patients according to NRI and CONUT, respectively. Diagnostic agreement between NRI and CONUT was weak (k = 0.306, p ˂ 0.001). The numerical CONUT score predicted the long-term mortality of patients (AUC 0.771, p ˂ 0.001) with an optimal cut-off ≥ 7 points. NRI had a worse predictive ability (AUC 0.673, p ˂ 0.001). Conclusion. The Controlling Nutritional Status (CONUT) score is an acceptable tool for diagnosing malnutrition in LC patients and can predict the long-term mortality of patients. The Nutritional Risk Index (NRI) has low diagnostic agreement with CONUT and lower predictive value.

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Inflammatory status predicts prognosis in patients with gastric cancer with early pyloric stenosis who underwent radical resection: A propensity score‑matching analysis

He,

Li,

et al. 2024

Oncol Lett

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The inflammatory status of patients is closely related to their nutritional status, and the impact of inflammatory status on patients with pyloric stenosis remains unclear. The present study aimed to investigate the impact of inflammatory status on the prognosis of patients with gastric cancer with early pyloric stenosis who underwent radical resection. A retrospective analysis included 242 patients with gastric cancer who underwent radical resection at the Affiliated Hospital of Southwest Medical University between July 2016 and December 2020. All patients were diagnosed with early pyloric stenosis. Correlation analysis was used to assess variations among different factors, and survival analysis was conducted to evaluate differences in overall survival (OS). To identify independent prognostic indicators, both univariate and multivariate Cox regression analyses were performed, addressing potential multicollinearity using Lasso analysis. Propensity score matching (PSM) was employed to eliminate potential confounding factors. Additionally, a prognostic risk model and nomogram based on inflammatory indicators were developed to comprehensively explore their impact on prognosis. Initial survival analysis revealed significant associations between neutrophil-to-lymphocyte ratio (NLR; χ 2 =10.522, P<0.001), systemic immune-inflammation index (SII; χ 2 =6.733, P=0.025), systemic inflammation response index (SIRI; χ 2 =15.490, P<0.001) and OS of the patients, while there was no significant survival difference among patients with different platelet-to-lymphocyte ratio (PLR; χ 2 =2.561, P=0.050). SIRI not only had the highest area under the curve but was also found to be an independent prognostic indicator (hazard ratio=1.851, P=0.046) in the present study. Following PSM on SIRI, a total of 174 patients were included in the subsequent analysis. Time-receiver operating characteristic and survival curves for SIRI after PSM consistently demonstrated its robust prognostic predictive capability. Furthermore, the prognostic risk model based on SIRI and the nomogram incorporating SIRI both exhibited high prognostic value. Inflammatory status was significantly associated with the prognosis of patients with gastric cancer with early pyloric stenosis who underwent radical resection. The NLR, SII and SIRI could all predict patient outcomes. Moreover, SIRI exhibited the highest prognostic value among the inflammatory indices and has been identified as an independent prognostic factor in the present study.

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Nutritional risk index predicts the prognosis of gastric cancer patients with pyloric stenosis who received preoperative parenteral nutrition

Cited by 3 publications

References 45 publications

Effect of different preoperative nutritional treatments on postoperative recovery and clinical outcomes in patients with gastric cancer and early gastric outlet obstruction

Effect of different preoperative nutritional treatments on postoperative recovery and clinical outcomes in patients with gastric cancer and early gastric outlet obstruction

The use of clinical and biochemical tools of nutritional status assessment in predicting the course of liver cirrhosis

Inflammatory status predicts prognosis in patients with gastric cancer with early pyloric stenosis who underwent radical resection: A propensity score‑matching analysis

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