Nutritional status and food intake in patients with systemic lupus erythematosus

Borges, Mariane; Santos, Fabiana de Miranda Moura dos; Telles, Rosa Weiss; Lanna, Cristina Costa Duarte; Correia, María Isabel Toulson Davisson

doi:10.1016/j.nut.2012.01.015

Cited by 64 publications

(62 citation statements)

References 26 publications

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“…Although several studies have reported the positive correlation between obesity and a higher prevalence or worse prognosis of SLE [6,7,35,37], to our knowledge, this is the first study to demonstrate that the SLE onset is influenced by weight gain and is preceded by an increase in ROS production by blood neutrophils.…”

Section: Discussionmentioning

confidence: 63%

Systemic lupus erythematosus onset in lupus-prone B6.MRL/lpr mice Is influenced by weight gain and Is preceded by an increase in neutrophil oxidative burst activity

Toller-Kawahisa

Canicoba

Venâncio

et al. 2015

Free Radical Biology and Medicine

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In this study, we assessed whether weight gain influenced the systemic lupus erythematosus (SLE) onset and/or outcome, and examined the role that reactive oxygen species (ROS) production by neutrophils played in the SLE onset and/or outcome. Female control (C57BL/6) and lupus-prone B6.MRL/lpr mice (CM and LPM, respectively) at 4 weeks old were fed standard diet or standard diet plus cafeteria diet during 12 weeks. SLE diagnosis relied on the presence of both antinuclear antibodies (ANA) and renal abnormalities. We found that the percentage of weight gain in CM and LPM increased as a function of the length of cafeteria diet feeding period, but it was not associated with energy intake. Cafeteria diet-fed CM and LPM at 8 and 12 weeks old were overweight, while CM and LPM at 16 weeks old were obese. Compared with standard diet-fed CM and LPM, cafeteria diet-fed CM and LPM exhibited elevated glucose and total cholesterol levels, and diminished triglycerides levels. Standard diet-fed 16-week-old LPM and cafeteria diet-fed 12-week-old LPM had nephritis, characterized by the increased interstitial infiltration of leukocytes. Cafeteria diet-induced weight gain rose the frequency of homogeneous and speckled ANA staining patterns in the 12- and 16-week-old LPM groups. Together, these results indicated that weight gain anticipated the SLE onset. In addition, neutrophils from cafeteria diet-fed 8-week-old LPM exhibited augmented ROS production capacity; in standard diet-fed LPM, such rise occurred only in the 16-week-old group. Thus, the neutrophil ROS production capacity was increased before the SLE onset and during its outcome. Overweight and obese CM and LPM displayed elevated levels of kidney, liver, heart, and spleen lipid peroxidation. In conclusion, cafeteria diet-induced weight gain is associated with the increased production of ANA and neutrophil-derived ROS, which may contribute to accelerate the SLE onset.

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Section: Discussionmentioning

confidence: 63%

Systemic lupus erythematosus onset in lupus-prone B6.MRL/lpr mice Is influenced by weight gain and Is preceded by an increase in neutrophil oxidative burst activity

Toller-Kawahisa

Canicoba

Venâncio

et al. 2015

Free Radical Biology and Medicine

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“…AND/ASPEN considers that if ≥2 of the following 6 characteristics are present, the patient is malnourished: insufficient energy intake, weight loss, loss of muscle mass, loss of subcutaneous fat, localized or generalized fluid accumulation that may sometimes mask weight loss, and diminished functional status as measured by handgrip strength. In addition, several authors have compared these 2 tools with other used instruments that provide the diagnosis and predict morbidity, mortality, length of stay, and costs …”

Section: Nutrition Assessmentmentioning

confidence: 99%

Nutrition Screening vs Nutrition Assessment: What’s the Difference?

Correia

2017

Nut in Clin Prac

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Screening and assessment imply different processes, with the former indicating risk factors for a deprived nutrition condition and the latter providing the nutrition diagnosis. Both should be routinely performed at hospital admission according to recommended guidelines; however, this is not the reality worldwide, and undernutrition remains highly prevalent in the hospital setting. Therefore, the objective of the current review is to delve into the principles leading to nutrition status deficiencies and how they should be addressed by screening and assessment. A critical appraisal for the reasons associated with the misunderstanding between screening and assessing is proposed without further discussing the many available screening tools while approaching some of the assessment instruments. (Nutr Clin Pract. 2018;33:62-72)

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“…Elevated IL-37 levels in humans are generally found in patients with inflammatory diseases such as nonallergic asthma [32] and systemic lupus erythematosus (SLE) [33]. SLE patients have indeed been reported to have inadequate food intake [34], which would be consistent with higher IL-37, but the complexity and versatility of the immune system makes it challenging to attribute this effect to a specific inflammatory component. Recent genetic studies on body mass index revealed that a majority of the tissues and cell types in which genes near BMI-associated SNPs are highly expressed, are part of the central nervous system [35].…”

Section: Discussionmentioning

confidence: 99%

IL-37 Expression Reduces Lean Body Mass in Mice by Reducing Food Intake

Kuipers

Ballak

Wit

et al. 2018

IJMS

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The human cytokine interleukin (IL)-37 is an anti-inflammatory member of the IL-1 family of cytokines. Transgenic expression of IL-37 in mice protects them from diet-induced obesity and associated metabolic complications including dyslipidemia, inflammation and insulin resistance. The precise mechanism of action leading to these beneficial metabolic effects is not entirely known. Therefore, we aimed to assess in detail the effect of transgenic IL-37 expression on energy balance, including food intake and energy expenditure. Feeding homozygous IL-37 transgenic mice and wild-type (WT) control mice a high-fat diet (HFD; 45% kcal palm fat) for 6 weeks showed that IL-37 reduced body weight related to a marked decrease in food intake. Subsequent mechanistic studies in mice with heterozygous IL-37 expression versus WT littermates, fed the HFD for 18 weeks, confirmed that IL-37 reduces food intake, which led to a decrease in lean body mass, but did not reduce fat mass and plasma lipid levels or alterations in energy expenditure independent of lean body mass. Taken together, this suggests that IL-37 reduces lean body mass by reducing food intake.

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Nutritional status and food intake in patients with systemic lupus erythematosus

Abstract: The results showed that patients with SLE have inadequate nutritional status and food intake.

Cited by 64 publications

References 26 publications

Systemic lupus erythematosus onset in lupus-prone B6.MRL/lpr mice Is influenced by weight gain and Is preceded by an increase in neutrophil oxidative burst activity

Systemic lupus erythematosus onset in lupus-prone B6.MRL/lpr mice Is influenced by weight gain and Is preceded by an increase in neutrophil oxidative burst activity

Nutrition Screening vs Nutrition Assessment: What’s the Difference?

IL-37 Expression Reduces Lean Body Mass in Mice by Reducing Food Intake

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