Nutritional status of HIV-seropositive subjects in an AIDS clinic in Paris

Niyongabo, T; Bouchaud, Olivier; Henzel, D.; Melchior, J.C.; Samb, Badara; Mc, Dazza; Ruggeri, Catherine; Jc, Begue; Coulaud, J P; Larouzé, Bernard

doi:10.1038/sj.ejcn.1600461

Cited by 34 publications

(23 citation statements)

References 19 publications

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“…The signi®cantly higher percentage of patients in group III than in group I that showed depleted lean body mass (UBMA`5th centile) is in concordance with the study of HIV-infected outpatients in Abidjan, which also demonstrated a decrease in lean body mass as the disease progresses (Castetbon et al, 1997). It was also shown that a decrease in lean body mass was related to the decrease in body cell mass (Niyongabo et al, 1997) and that body cell mass depletion was out of proportion to losses of body weight for fat (Kotler, 1992). Kotler et al (1989) also demonstrated that death from wasting in AIDS is related to the body cell mass depletion rather than the speci®c underlying cause of the wasting.…”

Section: Nutritional Status Of Hiv-1 Positive Patientssupporting

confidence: 87%

Nutritional status of HIV-1 seropositive patients in the Free State Province of South Africa: Anthropometric and dietary profile

et al. 1999

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Objective: To evaluate the nutritional intake and status of HIV-1 seropositive patients, as well as the relationship between malnutrition and disease stage. Design: A cross-sectional study. Settings: The Immunology Clinic at the Pelonomi Hospital in Bloemfontein, South Africa. Subjects: Eighty-one HIVaAIDS patients in different stages of disease were recruited consecutively from January to May 1995. Eleven of these patients were followed in 1997. Main outcome measures: Anthropometric data including current weight, height, triceps skinfold thickness, midupper-arm circumference, body mass index and bone-free arm muscle area were collected. Nutrient intake was estimated using a diet history in combination with a standardised food frequency questionnaire. The patients were divided into 3 groups according to their CD4 T cell counts. Results: The men were leaner (BMI 18.9) than the women (BMI 22.7) and patients with a CD4T cell count`200 (stage III) tended to have the lowest median values for all anthropometric measurements. More than half the patients had a low intake (`67% of the recommended dietary allowances) of vitamin C, vitamin B 6 , vitamin D, vitamin A, calcium, iron and zinc. Conclusions: The results con®rms that HIVaAIDS patients from this population are malnourished. There was, however, no association between disease stage and nutritional status. Nutritional supplementation of HIVaAIDS patients should be considered, as this might lead to improved immune function in these patients.

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Section: Nutritional Status Of Hiv-1 Positive Patientssupporting

confidence: 87%

Nutritional status of HIV-1 seropositive patients in the Free State Province of South Africa: Anthropometric and dietary profile

et al. 1999

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“…According to the usual criteria (Morgan et al, 1980;Ysseldyke, 1991;Niyongabo et al, 1997), patients were categorised into three classes on the basis of the percentage of body weight loss (BWL), calculated by reference to the usual body weight (UBW), as follows: (i)BWL 10% (no malnutrition) (ii) 10%`BWL 20% (moderate malnutrition) (iii)BWL b 20% (severe malnutrition).…”

Section: Methodsmentioning

confidence: 99%

Nutritional status of adult inpatients in Bujumbura, Burundi (impact of HIV infection)

et al. 1999

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Objective: To determine the prevalence and analyse the characteristics and causes of malnutrition among inpatients in an HIV highly endemic area. Design: Prospective cross-sectional study. Setting: Department of Internal Medicine, University Hospital, Bujumbura, Burundi. Subjects: 226 adult inpatients. Main outcomes measures: Evaluation of nutritional status using anthropometry. Degree of malnutrition de®ned by the percentage of body weight loss (BWL), calculated by reference to the usual body weight. Results: Among the 226 patients recruited (mean age: 34.4 AE 11.9 y, M:F sex ratio: 1.72), 102 (45.1%) were HIV seropositive. 62 (60.8%) of these HIV seropositive were AIDS cases. The AIDS de®ning criterion was wasting syndrome' for 25 (40.3%) and opportunistic infection (OI) for 37 (59.7%) including 34 cases of tuberculosis (TB). The nutritional status of 119a226 patients (52.7%) was normal (BWL 10%). Moderate malnutrition (10% BWL 20%) was observed in 47 (20.8%) and severe malnutrition (BWL b 20%) was observed in 60 (26.5%). HIV seroprevalence and, among HIV seropositive subjects, the percentage of AIDS cases increased according to decreasing level of nutrition (Chi2 for trends: P`0.001 in both instances). The fat free mass mass of malnourished subjects was lower and the fat body mass was higher among HIV seropositive subjects than HIV seronegative subjects. Among HIV seropositive subjects, malnutrition was associated with TB (P`0.001) and dysphagia (P`0.05). Among HIV seronegative subjects, malnutrition was associated with decreased food availability (P`0.003) and TB (P`0.05). One week after admission, the mortality rate was higher among HIV seropositive subjects (10.8%) than seronegative subjects (2.4%, P 0.009). Other factors associated with death were decreased fat free mass (P`0.01) and tricipital skinfold thickness (P`0.04). Conclusions: The prevalence of malnutrition is high among the inpatients investigated. Main factors are HIV infection and TB. Strategies adapted to the African context should be developed to prevent, detect and treat malnutrition and associated factors, particularly among HIV seropositive subjects.

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“…This finding is similar to that reported by Castetbon et al (Kennedy et al, 2001) and (Dannhauser et al, 1999). It has been shown that a decrease in the lean body mass is related to the decrease in body cell mass (Niyongabo et al, 1997) and that body cell mass depletion is out of proportion to losses of body weight for fat (MacClave & Mittoraj, 1992;Castetbon et al, 1997;Kotler, 1992). It has also been shown that death from wasting in AIDS is related to the body cell mass depletion rather than to the specific underlying cause of the wasting (Kotler et al, 1989).…”

Section: Studies In Developed Countries Have Reported the Impact Of Hmentioning

confidence: 99%

“…Research has shown that in the early period of HIV infection, weight gain or maintenance might be achieved through nutrition intervention, and this has helped to reduce the consequences of wasting in people living with HIV/AIDS [Babamento & Kotler, 1997;Dwyer, 1998;Cimoch, 1997;Niyongabo et al, 1997). In the developing world, where the majority of people living with HIV cannot afford antiretroviral therapy, good nutrition combined with mineral and vitamin supplementation could be a strategic alternative source of therapy.…”

Section: Introductionmentioning

confidence: 99%

“…Few studies (Dannhauser et al, 1999;Niyongabo et al, 1999) have examined the relationship between HIV infection and adult anthropometry in South Africa and elsewhere in Africa. However, none has examined the association between HIV infection, anthropometry and nutrient supplementation in adult male and female populations, hence the reason to examine the potential effect of nutrient supplementation on anthropometric profiles of HIV-positive/AIDS patients.…”

Section: Introductionmentioning

confidence: 99%

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Potential effects of nutrient supplement on the anthropometric profiles of HIV-positive patients: complementary medicine could have a role in the management of HIV/AIDS

Oguntibeju¹,

Heever²,

Schalkwyk³

2010

African Journal of Biomedical Research

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This is a purposive open-ended study that consisted of a baseline, monthly and final measurements (at the end of nutrient supplementation) that lasted for six months. Anthropometric measurements (BMI, percentage fat, waist-to-hip ratio and lean body mass) were done at baseline, monthly and at the end of study (final measurement) using known standard methods. The Tlymphocytes subsets were determined using flow cytometer. Participants fulfilled certain criteria for inclusion in the study. At baseline, of the 35 patients recruited into the study, 32 (94.1%) showed a fat percentage below normal range. Twenty-four of the patients (68.6%) had body mass index (BMI) within normal range, while a greater percentage of the patients had a normal waist-to-hip ratio (WHR). Of the 28 patients that completed the study, 26 (96.3%) reported a fat percentage of below 18.5%. There was no significant difference (P>0.05) between the fat percentage at baseline and end of the study in the whole group. The results showed that 19 (67.9%) of the 28 patients had a BMI within the normal range after nutrient intervention. There was a significant positive correlation between the BMI and fat percentage. At the end of the study, the CD4 + T-cell count showed no positive correlation with any of the anthropometric indices. The supplement showed no significant effect on the anthropometrics. Further study with large sample size is recommended to confirm supplement effect on the anthropometric profiles. The short duration of the study probably limited the positive trend of the supplement on the anthropometric profiles.

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Nutritional status of HIV-seropositive subjects in an AIDS clinic in Paris

Cited by 34 publications

References 19 publications

Nutritional status of HIV-1 seropositive patients in the Free State Province of South Africa: Anthropometric and dietary profile

Nutritional status of HIV-1 seropositive patients in the Free State Province of South Africa: Anthropometric and dietary profile

Nutritional status of adult inpatients in Bujumbura, Burundi (impact of HIV infection)

Potential effects of nutrient supplement on the anthropometric profiles of HIV-positive patients: complementary medicine could have a role in the management of HIV/AIDS

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