Nutritional Status of Patients With Leprosy Attending a Tertiary Care Institute in North India

Jindal, Rashmi; Nagrani, Prateek; Chauhan, Payal; Bisht, Yashwant Singh; Sethi, Sheenam; Roy, Samarjit

doi:10.7759/cureus.23217

Cited by 3 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…16 Jindal et al in 2021 observed 49.5% cases in Borderline Tuberculoid (BT) followed by 21.3% in Lepromatous Leprosy (LL), 14.5% in Borderline Lepromatous (BL), 5.3% in Mid Borderline (BB) and 1.9% cases of Tuberculoid Leprosy (TT). 19 In our study, paucibacillary cases comprised of 30 (66.7%), followed by multibacillary cases; 15 (33.3%). Quaresma et al in 2012 reported equal percentage of paucibacillary and multibacillary cases.…”

Section: Discussionmentioning

confidence: 46%

Immunoexpression of TGF-β: An utility marker in hansen’s disease

Akhtar¹,

Warsi

Lubna³

et al. 2023

ACHR

View full text Add to dashboard Cite

TGF-β is a pleiotropic cytokine that deploys several functions on different types of cells. In the lepromatous (LL) form of Leprosy, there is predominance of M2 macrophages, which induce the production of growth factors, such as TGF-β which is important for the mechanisms that cause apoptosis and healing. To study the immunoexpression of TGF-β in Hansen’s disease and to assess the severity of infection with potential response to treatment. The present study was carried out in 45 patients of Hansen’s disease after a detailed history and thorough physical examination performed in every subject and punch biopsies were performed. The specimens were fixed, paraffin embedded and sections of 3-5 microns thickness were cut and stained with hematoxylin and eosin stains. Additional sections of 3-4 microns thickness were cut and immunohistochemical staining by TGF-β antibody was performed. Of the 45 cases of Hansen’s disease, most of the cases were of Borderline Tuberculoid and Borderline Lepromatous, constituting 14 (31.1%) cases each, followed by 9 (20.0%) cases of Lepromatous Leprosy. Maximum cases, 12 (26.7%) each with intense reaction were of Borderline Tuberculoid and Borderline Lepromatous, followed by 6 (13.3%) cases of Lepromatous Leprosy. Most of the cases, 9 (20.0%) were of Borderline Lepromatous category with highest proportion score, followed by 7 cases (15.6%) of Borderline Tuberculoid. Highest number of cases, 9 (20.0%) with high immunoreactivity score were in Borderline Lepromatous, whereas most of the cases, 7(15.6%) with low immunoreactivity score were in Borderline Tuberculoid. The immunoexpression of TGF-β was more intense in lepromatous side of the spectrum as compared to the tuberculoid, which indicates the severity of the disease with less cure potential.

show abstract

Section: Discussionmentioning

confidence: 46%

Immunoexpression of TGF-β: An utility marker in hansen’s disease

Akhtar¹,

Warsi

Lubna³

et al. 2023

ACHR

View full text Add to dashboard Cite

show abstract

“…These studies showed no association between leprosy reactional states and BMI. Furthermore, BMI failed to correlate with the presence of reaction leprosy and deformities or multibacillary disease in the reported studies (p>0.05) [41,42]. Another study from Indonesia reported no significant association between poor nutrition and leprosy (p = 0.008, OR = 0.422) [43].…”

Section: Discussionmentioning

confidence: 77%

The nutritional status of mycetoma affected patients seen at the Mycetoma Research Center, Sudan

Gabani,

Ahmed,

Hassan

et al. 2024

PLoS Negl Trop Dis

View full text Add to dashboard Cite

Nutrition plays a critical and crucial role in addressing neglected tropical diseases (NTDs) and their complications, as they often contribute to malnutrition, which can worsen the impact of these conditions. Therefore, it is necessary to investigate the nutritional status of mycetoma patients, which has not been explored previously. This descriptive cross-sectional hospital-based study was conducted at the Mycetoma Research Center (MRC), University of Khartoum, Sudan. The study included 179 confirmed mycetoma patients and an equal number of age- and sex-matched normal controls. The nutritional status of the mycetoma patients was assessed and compared with that of the control group. The majority of the patients were young adults with varying educational levels, predominantly from Central Sudan. The foot was the most commonly affected part; most patients had lesions more than 10 cm in diameter. The Body Mass Index (BMI) was calculated for both study groups, revealing that 43.5% of the patients and 53.6% of controls had a normal BMI. Furthermore, 36% of patients were underweight, contrasting with only 11% in the control group. Correlation analyses indicated no significant associations between BMI and age groups, educational levels, daily meals, food quantity, and appetite in the study population (p > 0.05). Similarly, no significant differences were observed in BMI concerning disease duration and affected sites (p = 0.0577). The Kruskal-Wallis test did not reveal significant differences in BMI means among the groups. The study revealed that most participants consumed three meals daily, and the control group showed a more robust appetite and consumed more food than the patient group (p = 0.005). Nevertheless, there were no significant differences in the consumption of different food types between the patient and control groups and among different BMI categories (p = 0.025 and 0.040, respectively).

show abstract

A Scoping Review of Nutrition and Diet-Related Factors in Combating Leprosy Disease

Rusyda

2024

Journal of Nutrition College

View full text Add to dashboard Cite

Background: Indonesia still faces several challenges concerning the control of neglected tropical diseases (NTDs). Leprosy is one of the bacterial infectious NTDs caused by Mycobacterium leprae. The most obvious risk factors include undernutrition, poverty, food scarcity, food insecurity and a lack of food diversity. According to immunity beneficiaries and preventable or protecting factors, nutrition and food are essential.Objectives: To synthesize the diet and nutrition risk factors and consequences with the most substantial evidence related to leprosy disease.Methods: Five databases were searched systematically, following punctuation and conventions-based keyword searches and criteria and free-text terms. Selected articles included systematic reviews and other studies involving human subjects published between 2013 and 2023. Finding articles (n=588) were interpreted using preferred reporting of items for systematic reviews and meta-analyses (PRISMA). Eligible articles (n=16) were described by author’s name, publication year, study objectives, locations, study design, participants, methods, intervention and exposure, and critical findings and impacts/outputs.Results: In 16 studies, there were nutrition explanations correlated to leprosy disease. Malnutrition, either undernutrition or overnutrition, may lead to a worse disease prognosis. A comprehensive approach to food security, diet quality, and dietary behaviors is needed to protect against the disease. Affected individuals tend to have lower essential nutrition serum levels to obtain multiple micronutrient supplements such as vitamins A, C, D, E, zinc and selenium.Conclusion: Regarding immunity beneficiaries and impacted factors, there are several potential risk factors related to nutrition and diet in leprosy that are necessary considerations, including nutritional status, food and nutritional security (food environment-related) and dietary behavior. Keywords: Food insecurity; Immune responses; Leprosy; Neglected tropical disease; Nutrition vulnerability.

show abstract

Nutritional Status of Patients With Leprosy Attending a Tertiary Care Institute in North India

Cited by 3 publications

References 9 publications

Immunoexpression of TGF-β: An utility marker in hansen’s disease

Immunoexpression of TGF-β: An utility marker in hansen’s disease

The nutritional status of mycetoma affected patients seen at the Mycetoma Research Center, Sudan

A Scoping Review of Nutrition and Diet-Related Factors in Combating Leprosy Disease

Contact Info

Product

Resources

About

Nutritional Status of Patients With Leprosy Attending a Tertiary Care Institute in North India

Cited by 3 publications

References 9 publications

Immunoexpression of TGF-&beta;: An utility marker in hansen’s disease

Immunoexpression of TGF-&beta;: An utility marker in hansen’s disease

The nutritional status of mycetoma affected patients seen at the Mycetoma Research Center, Sudan

A Scoping Review of Nutrition and Diet-Related Factors in Combating Leprosy Disease

Contact Info

Product

Resources

About

Immunoexpression of TGF-β: An utility marker in hansen’s disease

Immunoexpression of TGF-β: An utility marker in hansen’s disease