Nutritional supplementation on wound healing in diabetic foot: What is known and what is new?

Porto, Andrea Da; Miranda, Cesare; Brosolo, Gabriele; Zanette, Giorgio; Michelli, Andrea; Ros, Roberto Da

doi:10.4239/wjd.v13.i11.940

Cited by 8 publications

(3 citation statements)

References 49 publications

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“…There are various ways to treat diabetic ulcers, and specific treatment plans should be formulated according to the condition and individual needs. [44][45][46][47] At present, there are some research and developments on the new methods and directions of treating diabetic ulcer nonunion at home and abroad. The following are the more significant new approaches and tips: 1.…”

Section: Discussionmentioning

confidence: 99%

Effect of Diabetes on Wound Healing: A Bibliometrics and Visual Analysis

Lang,

Li,

et al. 2024

JMDH

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Objective The quality of life of diabetic patients is seriously affected by wound healing difficulty, which can lead to increased infection, skin deep tissue injury and continuous pain. By analyzing the research trends and hot spots in this field, the visualization analysis map is constructed. Methods The contents of the selected articles were sorted out and analyzed by bibliometrics. We use CiteSpace, Vosviewer and HistCite to visualize literature information, including national publication statistics, institutions, authors, journal partnerships, and citations of published articles. Results Among the 2942 articles, the United States and China ranked first in both article circulation and TGCS, and many countries also cooperated. The collaboration between schools and research institutions is a core part of dissertation research institution collaboration, with most authors coming from the same institution. Most of the literature studies on the mechanisms and methods of promoting diabetic wound healing. Improving cell function or making innovative attempts in local treatment are the fruits of researchers’ efforts to promote diabetic wound healing in recent years. Conclusion Through the metrology method, the time distribution, author institution, cooperation network, research status, research hotspot and development trend of the literature on the influence of diabetes on wound healing were intuitively displayed, which provided a reference for further research and development direction.

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Section: Discussionmentioning

confidence: 99%

Effect of Diabetes on Wound Healing: A Bibliometrics and Visual Analysis

Lang,

Li,

et al. 2024

JMDH

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“…For example, it was recently reported that the MADADORE acronym corresponds to the recommended DFU management principles: Metabolic control, Assessment of foot, Debridement, Antibiotics, Dressing, Offloading pressure, Referral to multidisciplinary teams, and Education [ 50 ]. Metabolic control involves the management of associated medical conditions such as hyperglycemia and hyperlipidemia, through adequate medication and dietary counseling [ 51 ]. Assessment of foot concerns the correct evaluation of the associated risk factors and classification of the ulcer according to the perfusion, extent, depth, infection, and sensation (PEDIS) scale [ 52 ].…”

Section: Diabetic Foot Ulcer: a Multifactorial Emerging Issuementioning

confidence: 99%

Innovative Functional Biomaterials as Therapeutic Wound Dressings for Chronic Diabetic Foot Ulcers

Silva

Leal

Carvalho

et al. 2023

IJMS

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The imbalance of local and systemic factors in individuals with diabetes mellitus (DM) delays, or even interrupts, the highly complex and dynamic process of wound healing, leading to diabetic foot ulceration (DFU) in 15 to 25% of cases. DFU is the leading cause of non-traumatic amputations worldwide, posing a huge threat to the well-being of individuals with DM and the healthcare system. Moreover, despite all the latest efforts, the efficient management of DFUs still remains a clinical challenge, with limited success rates in treating severe infections. Biomaterial-based wound dressings have emerged as a therapeutic strategy with rising potential to handle the tricky macro and micro wound environments of individuals with DM. Indeed, biomaterials have long been related to unique versatility, biocompatibility, biodegradability, hydrophilicity, and wound healing properties, features that make them ideal candidates for therapeutic applications. Furthermore, biomaterials may be used as a local depot of biomolecules with anti-inflammatory, pro-angiogenic, and antimicrobial properties, further promoting adequate wound healing. Accordingly, this review aims to unravel the multiple functional properties of biomaterials as promising wound dressings for chronic wound healing, and to examine how these are currently being evaluated in research and clinical settings as cutting-edge wound dressings for DFU management.

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“…However, the number of high-quality randomized controlled trials is small, and the evidence on the effects of nutritional interventions in patients with diabetic foot ulcers is uncertain. The IWGDF (International Working Group on the Diabetic Foot) 2019 guidelines [24] are as follows: Do not use interventions aimed at correcting the nutritional status (including supplementation of protein, vitamins, trace elements, and pharmacotherapy with agents promoting angiogenesis) of patients with diabetic foot ulcers to improve healing, in preference to the best standard of care (GRADE recommendation: Strong; Quality of evidence: Low) [25].…”

Section: Nutrition Guidelines For Diabetic Foot Ulcer Patientsmentioning

confidence: 99%

Role of nutrition in wound healing and nutritional recommendations for promotion of wound healing: a narrative review

Ju,

Kim,

Seo

2023

Ann Clin Nutr Metab

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Addressing both malnutrition and wound healing requires strategic intervention. However, guidelines for adequate nutrition for a variety of wounds are lacking. Based on the latest literature review, we summarize the role of nutrition in each stage of wound healing and nutritional recommendations for wound healing. Current concept: Wounds undergo three healing phases: inflammatory, proliferative, and remodeling. The inflammatory phase involves clotting and cleaning the wound. The proliferative phase builds the wound bed through tissue growth. In the remodeling phase, collagen strength increases. Proper nutrition is crucial throughout. During inflammation, calcium, vitamin K, A, and E, zinc, and proteins are essential. In proliferation, amino acids, B vitamins, lipids, zinc, and iron play key roles. During remodeling, vitamins C and E, zinc, and water are critical for collagen synthesis and skin cell maturation. Vulnerable groups like the elderly, newborns, and obese patients need proper nutrition for skin maintenance. For pressure ulcers with malnutrition risk, recommendations are 30-35 kcal/kg/day energy, 1.25-1.5 g/kg/day protein, and 30 mL/kg water. Supplements might be added if regular meals don't meet needs. For diabetic foot ulcers, despite common deficiencies, the 2019 International Working Group on the Diabetic Foot advises against prioritizing nutritional interventions over standard care due to limited high-quality evidence. Conclusion: Despite limited guidelines, nutrition assessment is vital for wound evaluation. A multidisciplinary approach is key, emphasizing nutrition's role in wound healing. Implementing nutritional interventions tailored to the wound and the individual's nutritional status is essential. This comprehensive strategy ensures the best wound care outcomes.

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Nutritional supplementation on wound healing in diabetic foot: What is known and what is new?

Cited by 8 publications

References 49 publications

Effect of Diabetes on Wound Healing: A Bibliometrics and Visual Analysis

Effect of Diabetes on Wound Healing: A Bibliometrics and Visual Analysis

Innovative Functional Biomaterials as Therapeutic Wound Dressings for Chronic Diabetic Foot Ulcers

Role of nutrition in wound healing and nutritional recommendations for promotion of wound healing: a narrative review

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