Nutritional Supplementation with the Mushroom <i>Agaricus sylvaticus</i> Reduces Oxidative Stress in Children with HIV

Figueira, Marcela Souza; Sá, Luana A; Vasconcelos, Amanda Soares de; Moreira, Danilo Reymão; Laurindo, Paula S. O. C.; Ribeiro, Danielle Rg; Santos, Rogério Silva; Guzzo, Paulo; Dolabela, Maria Fâni; Percário, Sandro

doi:10.1155/2014/609016

Cited by 10 publications

(5 citation statements)

References 40 publications

(45 reference statements)

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“…HIV infection and highly active antiretroviral therapy (HAART) can cause oxidative stress. Nutrition supplementation with mushroom extracts could reduce oxidative stress in HIV patients ( Figueira et al, 2014 ). From these findings, mushroom extracts can be used to treat HIV-infected patients in the form of crude extracts/purified bioactive substances or sole extracts/drug tonics against HIV itself as well as be a part of nutrition supplementation or skin cream to treat skin infection.…”

Section: Discussionmentioning

confidence: 99%

Anti-HIV-1 reverse transcriptase property of some edible mushrooms in Asia

Choengpanya

Ratanabunyong

Seetaha

et al. 2021

Saudi Journal of Biological Sciences

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Human immunodeficiency virus (HIV) causes acquired immunodeficiency syndrome (AIDS), which is a serious health threat worldwide. One of its core enzymes, reverse transcriptase (RT), is a target for HIV inhibition. A number of bioactive compounds have been successfully used for HIV treatment. However, HIV rapidly mutates, and long-term treatment can cause drug-resistant strains. Therefore, new inhibitors are required to overcome this problem. In this study, the aqueous, ethanolic and hexane crude extracts of 19 edible and medicinal mushrooms, which are widely grown and available commercially in Thailand, were screened against HIV-1 RT. The results showed that the water extracts of A. blazei and I. obliquus , the ethanol extracts of I. obliquus and P. igniarius and the hexane extract of I. obliquus exhibited strong anti-HIV-1 RT activity with IC 50 values of 1.92 ± 0.15, 4.39 ± 0.79, 6.17 ± 0.76 and 7.75 ± 246 µg/ml, respectively. These mushrooms have the potential for HIV treatment, and further study on identification of the bioactive compounds against HIV-1 RT should be performed.

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Section: Discussionmentioning

confidence: 99%

Anti-HIV-1 reverse transcriptase property of some edible mushrooms in Asia

Choengpanya

Ratanabunyong

Seetaha

et al. 2021

Saudi Journal of Biological Sciences

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“…Os resultados observados corroboram diversos autores (ALLARD et al, 1998;BATTERHAM et al, 2001;JARUGA et al, 2002, DJOHAN et al 2009FIGUEIRA et al, 2014) A suplementação antioxidante, com vitamina A, C, E, selênio, realmente melhora a atividade de substâncias importantes no mecanismo da defesa antioxidante, como a glutationa e a glutationa peroxidase na infecção pelo HIV (BATTERHAM et al, 2001;SUDFELD et al, 2019), além disso, a intervenção nutricional com antioxidantes sintéticos e minerais conclui podem melhorar o estado nutricional e manter a função do sistema imune, através de uma redução no estresse oxidativo induzido pelas ERON (SUTTAJIT, 2007, ELZOHARY et al, 2019.…”

Section: Resultsunclassified

Coronavírus: Sars-Cov-2

Fagundes¹,

Silva²

2020

Atualidades Em Medicina Tropical No Brasil: Microbiologia

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RESUMOEm dezembro de 2019 foi isolado na cidade Wuhan, na China, um novo betacoronavírus, agente etiológico de uma nova doença. Foi denominado SARS-CoV-2 e a doença COVID-19. Este vírus se liga com alta afinidade ao receptor ECA2 e pode desencadear uma liberação maciça de citocinas e lesões em múltiplos órgãos. A Organização Mundial da Saúde (OMS) declarou em janeiro de 2020, que o surto da doença causada pelo novo coronavírus (COVID-19) constitui uma Emergência de Saúde Pública de Importância Internacional e 40 dias depois, caracterizou a COVID-19 como pandemia. No Brasil foram registrados até o dia 20/05/2020, 271.628 casos, com 17.971 óbitos, perfazendo uma taxa de letalidade de 6,6 %. Observa-se uma ascensão importante no número de casos, mesmo levando-se em conta que o Brasil apresenta uma elevadíssima taxa de subnotificação. A doença é transmitida por gotículas e/ou contato e se desenvolve em até 14 dias após a exposição. Em 81% dos casos apresenta-se de forma leve, porém em 14% dos casos apresenta-se de forma grave, com dispneia ou hipóxia ou envolvimento pulmonar acima de 50% em 24 a 48 horas de evolução. Doença crítica ocorre em 5% dos pacientes, manifestando-se com insuficiência respiratória, choque e disfunção de múltiplos órgãos. Não há tratamento ou profilaxias específicas estabelecidas; múltiplos estudos estão em andamento. As medidas não-farmacológicas ainda se constituem na única forma comprovadamente eficaz de se deter ou pelo menos tornar mais lenta a propagação desta doença, para ganhar tempo, e assim atender de forma adequada estes doentes, com uma compreensão maior desta patologia e possivelmente medicações e/ou vacinas eficazes.

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“…For example, NAC is an exogenous source of glutathione [ 36 , 37 ], which is one of the most important endogenous antioxidant molecules, whereas mushroom A. sylvaticus is composed of various antioxidant molecules that, in combination, have one of the highest values of antioxidant capacity currently found in natural products [ 14 ]. It is responsible for several therapeutic and preventive effects reported in recent literature [ 11 , 38 – 42 ]. Nevertheless, it was never used before against malaria.…”

Section: Discussionmentioning

confidence: 99%

N-acetyl cysteine and mushroom Agaricus sylvaticus supplementation decreased parasitaemia and pulmonary oxidative stress in a mice model of malaria

Gomes

Silva

Gomes

et al. 2015

Malar J

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BackgroundMalaria infection can cause high oxidative stress, which could lead to the development of severe forms of malaria, such as pulmonary malaria. In recent years, the role of reactive oxygen species in the pathogenesis of the disease has been discussed, as well as the potential benefit of antioxidants supplementation. The aim of this study was to investigate the effects of N-acetyl cysteine (NAC) or mushroom Agaricus sylvaticus supplementation on the pulmonary oxidative changes in an experimental model of malaria caused by Plasmodium berghei strain ANKA.MethodsSwiss male mice were infected with P. berghei and treated with NAC or AS. Samples of lung tissue and whole blood were collected after one, three, five, seven or ten days of infection for the assessment of thiobarbituric acid reactive substances (TBARS), trolox equivalent antioxidant capacity (TEAC), nitrites and nitrates (NN) and to assess the degree of parasitaemia.ResultsAlthough parasitaemia increased progressively with the evolution of the disease in all infected groups, there was a significant decrease from the seventh to the tenth day of infection in both antioxidant-supplemented groups. Results showed significant higher levels of TEAC in both supplemented groups, the highest occurring in the group supplemented with A. sylvaticus. In parallel, TBARS showed similar levels among all groups, while levels of NN were higher in animals supplemented with NAC in relation to the positive control groups and A. sylvaticus, whose levels were similar to the negative control group.ConclusionOxidative stress arising from plasmodial infection was attenuated by supplementation of both antioxidants, but A. sylvaticus proved to be more effective and has the potential to become an important tool in the adjuvant therapy of malaria.Electronic supplementary materialThe online version of this article (doi:10.1186/s12936-015-0717-0) contains supplementary material, which is available to authorized users.

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Nutritional Supplementation with the Mushroom Agaricus sylvaticus Reduces Oxidative Stress in Children with HIV

Cited by 10 publications

References 40 publications

Anti-HIV-1 reverse transcriptase property of some edible mushrooms in Asia

Anti-HIV-1 reverse transcriptase property of some edible mushrooms in Asia

Coronavírus: Sars-Cov-2

N-acetyl cysteine and mushroom Agaricus sylvaticus supplementation decreased parasitaemia and pulmonary oxidative stress in a mice model of malaria

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