Nutritional support in children undergoing bone marrow transplantation

Papadopoulou, Argyro; Williams, Michael D.; Darbyshire, P J; Booth, I W

doi:10.1016/s0261-5614(98)80306-3

Cited by 44 publications

(67 citation statements)

References 31 publications

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“…Similarly, Donaldson et al also claimed a deterioration of the nutritional status in 1/4 of the children who had radiotherapy due to abdominal and pelvic malignancies and did not receive parenteral nutrition (Donaldson et al, 1982). In our recent study in children undergoing BMT, the changes in weight and mid-arm circumference z-scores were greater in children receiving supplementary nasogastric tube feeding than in those who received conventional diet with added supplements and close dietetic counselling (Papadopoulou et al, 1997). The need, therefore, to provide nutritional support to this group of patients is almost universal.…”

Section: Nutritional Intervention Following Bmt: Which Route?supporting

confidence: 57%

“…In patients undergoing BMT, marrow recovery correlated signi®cantly with nutritional status at diagnosis (Yokohama et al, 1989). In our recent study in children undergoing BMT, poor nutritional status was associated with a greater frequency of febrile and vomiting episodes and longer hospital stay (Papadopoulou et al, 1998).…”

Section: Nutritional Status As a Determinant Of Outcomementioning

confidence: 80%

“…According to the same study, 11% of the patients admitted for BMT due to acute lymphocytic leukaemia had an admission weight less than 90% of IBW, 21% an AMA less than the 10th centile and 6% an AFA less than the 10th centile. In our recent study in children undergoing BMT, wasting and stunting were present in 18% and 31%, respectively, of children admitted for BMT (Papadopoulou et al, 1998).…”

Section: Indications For Bone Marrow Transplantation As Determinants mentioning

confidence: 80%

“…According to that study, an 11% decrease in skeletal muscle protein reserves was observed during the ®rst month following BMT. In our recent study in 47 children undergoing BMT, vomiting and diarrhoea occurred in 40% and 57% of the patients following BMT (Papadopoulou et al, 1996a;Papadopoulou et al, 1998). Poor nutritional status on admission was associated with a greater frequency of febrile and vomiting episodes and a longer hospital stay.…”

Section: Nutritional Insult Following Bone Marrow Transplantationmentioning

confidence: 85%

“…Decreases in serum magnesium have been also reported to occur following BMT (June et al, 1985). We reported recently that hypomagnesaemia was common in children following BMT and occurred irrespective of infections or diarrhoea, suggesting that its aetiology is probably multifactorial (Papadopoulou et al, 1997).…”

Section: Micronutrient De®cienciesmentioning

confidence: 86%

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Nutritional considerations in children undergoing bone marrow transplantation

Papadopoulou

1998

Eur J Clin Nutr

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Bone marrow transplantation is often associated with multiple organ failure which is usually reversible. Oral mucositis and dysphagia, vomiting, diarrhoea, protein losing enteropathy, transient exocrine pancreatic impairment, hypoalbuminaemia, biochemical trace element and mineral de®ciencies are all common following transplantation and have profound nutritional consequences. Malnutrition affects negatively the clinical outcome. Nutritional support is provided to malnourished patients and those who suffer deterioration in nutritional status despite the provision of dietetic counselling. Only a few randomised studies comparing enteral with parenteral nutrition after transplant exist. Both enteral tube feeding (in the absence of mucositis) and parenteral nutrition are effective in maintaining nutritional status. However, enteral nutrition is associated with a better nutritional response and fewer complications than parenteral. With existing enteral and parenteral nutrition regimens close monitoring of trace element and mineral status is required.

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Section: Nutritional Intervention Following Bmt: Which Route?supporting

confidence: 57%

Section: Nutritional Status As a Determinant Of Outcomementioning

confidence: 80%

Section: Indications For Bone Marrow Transplantation As Determinants mentioning

confidence: 80%

Section: Nutritional Insult Following Bone Marrow Transplantationmentioning

confidence: 85%

Section: Micronutrient De®cienciesmentioning

confidence: 86%

See 3 more Smart Citations