Nutritive utilization of calcium in rats: Effects of dietary fat components and vitamin D3 on intestinal resected rats.

Abstract

SummaryThe nutritive utilization of calcium was studied in adult rats in which 50% of the distal small intestine (DSI) had been resected and in sham-operated controls one month and three months after the operation. Resection of half the DSI reduced the digestive utilization of Ca as reflected by mineral content in bone. Three months after resection, nutritive utilization of Ca had still not recovered. Feeding the resected rats with a diet in which fat content consisted of equal parts of medium-chain triglycerides (MCT), sunflower seed oil, and olive oil failed to improve nutritive utilization of Ca after one or three months in comparison with a diet containing olive oil as the only source of lipids. Supplementation with vitamin D3 (0.04mg/100g diet) enhanced nutritive utilization of Ca in resected rats after one month, the beneficial effect becoming much more patent after three months. At the dose used, vitamin D3 favored calcium deposition in bone tissue. Serum levels of Ca remained unchanged under all experimental conditions, both one month and three months after 50% DSI resection.

Stereological study of the effect of black olive hydroalcoholic extract on osteoporosis in vertebra and tibia in ovariectomized rats

“…Recent studies demonstrated that oleuropein and hydroxytyrosol in olive were able to enhance deposition of calcium ions in osteoblastic MC 3 T 3 -E 1 cells and to inhibit osteoclast formation [24]. Also, olive enhanced the intestinal absorption of calcium [27]. Moreover, olive is an excellent source of gamma linolenic acid (GLA) which has been shown to reduce the excretion of calcium, inhibit bone reabsorption and markers of bone turnover, and at the same time increase the calcium content in the bone [28].…”

Olive Oil effectively mitigates ovariectomy-induced osteoporosis in rats

“…Olive oil enhances intestinal absorption of calcium [24]. Moreover, olive oil is an excellent source of gamma linolenic acid (GLA), which has been shown to reduce the excretion of calcium, inhibit bone reabsorption and markers of bone turnover while at the same time increases the calcium content in the bone [25].…”

Copper Malabsorption after Intestinal Resection in Rats

“…This effect, nonetheless, appears to play a smaller role in copper uptake than in calcium uptake [22], as active transport contributes less to the intestinal absorption of copper [10]. Some increase in the intestinal permeability might be expected (in control animals) in a long term administration of cholecalciferol.…”

“…An earlier study of the influence of this operation showed that biliary physiology was altered in rats subjected to DSI resection [13][14][15][16][17], These findings suggested that dietary fat consisting of equal parts of medium-chain triglycerides, sunflower oil and olive oil helped compensate for the impairment in mineral metabolism, as this source of fat has previously been shown to improve altered digestive function [16,17], and to improve the digestive utilization of fats [16, 20. 21] and of calcium and magnesium [22,23], Biliary copper excretion is the major ho meostatic regulator of body copper balance. Because intestinal resection alters biliary se cretion, it may secondarily reduce the diges tive utilization of copper.…”