Nutritive value of daily food rations of patients with psoriasis vulgaris: a preliminary report

Abstract

A b s t r a c t I In nt tr ro od du uc ct ti io on n: : Psoriasis is a chronic inflammatory systemic disorder. It has been suggested that dietary factors may influence the course and severity of the disease. A Ai im m: : To assess nutritive values of daily food rations (DFRs) of patients with psoriasis vulgaris and to correlate them with the severity of the disease, as well as to compare them with DFRs of patients with other chronic inflammatory skin disorders. M Ma at te er ri ia al l a an nd d m me et th ho od ds s: : The study was conducted among 39 out-patients with psoriasis vulgaris and 18 patients with other chronic inflammatory skin disorders. The severity of psoriasis was assessed using the Psoriasis Area and Severity Index (PASI). The dietary habits were evaluated using a 24-hour interview. The energetic and nutritive value of DFRs were calculated using Dieta 2 software and the statistical analysis was performed using Statistica 9.0 software. R Re es su ul lt ts s: : Daily food rations in psoriasis patients were characterized by an excessive intake of fats and energy derived from fats in both groups. Males and females with psoriasis consumed more monounsaturated fatty acids than controls. The PASI value in females correlated with the total intake of fatty acids and that of monounsaturated fatty acids. The intake of vitamin D 3 in females of both groups was very low. C Co on nc cl lu us si io on ns s: : The nutritive value of DFRs both in psoriasis patients and in controls was imbalanced taking into consideration various nutrients. K Ke ey y w wo or rd ds s: : psoriasis vulgaris, Psoriasis Area and Severity Index, body mass index, daily food rations, nutrients.

The Molecular Mechanisms by Which Vitamin D Prevents Insulin Resistance and Associated Disorders

“…It was revealed that vitamin D mediated, not only adipokines release, but also energetic homeostasis via the regulation of leptin formation. Another study showed that vitamin D suppressed the secretion of leptin by adipose tissue [ 257 ]. Additionally, CYP27B1 knockout mice were hypoleptinemic and consumed more food as compared to their wild type counterparts.…”

Obesity, adipose tissue function and the role of vitamin D

“…Many studies describe the link between vitamin D deficiencies and cardiovascular risk, diabetes mellitus, hypertension, and dyslipidemia [ 4 , 5 , 7 , 8 , 15 , 16 ]. Lower concentrations of circulating vitamin D were associated with a higher fasting glucose level, reduced insulin sensitivity, and increased risk of type II diabetes mellitus [ 8 , 11 , 13 , 17 ]. Moreover, low concentrations of vitamin D were observed in neoplasms, e.g.…”

“…Several studies prove the relationship between vitamin D concentrations and leptin. Vitamin D powerfully inhibits in vitro leptin secretion by human adipose tissue [ 17 ]. The clinical significance of the connections between leptin and vitamin D remains to be ascertained.…”

Psoriasis and Nutrition Interactions

“…Psoriasisli hastaları ve sağlıklı bireyler üzerinde yapılan başka bir çalışmada, hasta grubunun sağlıklı bireylere göre günlük enerji, karbonhidrat, kolesterol (sadece kadınlarda), posa, çoklu doymamış yağ asitleri, potasyum, kalsiyum, magnezyum alımları düşük ve protein, toplam yağ, doymuş yağ asitleri, sodyum, demir ve E vitamini tüketimleri yüksek bulunmuştur. Psoriasis Alan ve Şiddet İndeksi (PAŞİ, Psoriasis Area and Severity Index) skorları sadece kadın hastalarda toplam yağ asitleri ve özellikle tekli doymamış yağ asitleri tüketimleri ile ilişkilidir (4). Psoriasis ve diyet arasındaki ilişkiyi değerlendirmek üzere yapılan çalışmalarda yüksek miktarda posa (5), vitamin A ve α-karoten, havuç, domates gibi taze sebze ve meyve ile β-karoten alımı olan bireylerde psoriasis riskinin düşük olduğu ifade edilmiştir (6).…”