Nutritive vitamins as epidrugs

Nur, Suza Mohammad; Rath, Suvasmita; Ahmad, Varish; Ahmad, Abrar; Ateeq, Bushra; Khan, Mohammad Imran

doi:10.1080/10408398.2020.1712674

Cited by 62 publications

(44 citation statements)

References 105 publications

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“…However, they do not solve the problem of hypermethylation of specific loci of genes associated with DNA repair, apoptosis, and cancer suppression [ 886 , 887 , 888 ]. Intake of vitamin A and retinoic acid, vitamin C, vitamin E, vitamin D can potentially modulate the global DNA methylation profile, histone modifications, and microRNA activity [ 763 , 774 , 889 , 890 ]. Polyamines spermine and spermidine stimulate the activity of DNMT and inhibit aberrant DNA methylation [ 891 ].…”

Section: Pharmacological Interventions Protecting Genomementioning

confidence: 99%

Genome-Protecting Compounds as Potential Geroprotectors

Proshkina

Shaposhnikov

Moskalev

2020

IJMS

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Throughout life, organisms are exposed to various exogenous and endogenous factors that cause DNA damages and somatic mutations provoking genomic instability. At a young age, compensatory mechanisms of genome protection are activated to prevent phenotypic and functional changes. However, the increasing stress and age-related deterioration in the functioning of these mechanisms result in damage accumulation, overcoming the functional threshold. This leads to aging and the development of age-related diseases. There are several ways to counteract these changes: (1) prevention of DNA damage through stimulation of antioxidant and detoxification systems, as well as transition metal chelation; (2) regulation of DNA methylation, chromatin structure, non-coding RNA activity and prevention of nuclear architecture alterations; (3) improving DNA damage response and repair; (4) selective removal of damaged non-functional and senescent cells. In the article, we have reviewed data about the effects of various trace elements, vitamins, polyphenols, terpenes, and other phytochemicals, as well as a number of synthetic pharmacological substances in these ways. Most of the compounds demonstrate the geroprotective potential and increase the lifespan in model organisms. However, their genome-protecting effects are non-selective and often are conditioned by hormesis. Consequently, the development of selective drugs targeting genome protection is an advanced direction.

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Section: Pharmacological Interventions Protecting Genomementioning

confidence: 99%

Genome-Protecting Compounds as Potential Geroprotectors

Proshkina

Shaposhnikov

Moskalev

2020

IJMS

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“…Despite the exact relationship between diet and the epigenome remains unclear, several studies reported an association between epigenetic modifications and dietary depletion or supplementation (1,(42)(43)(44)(45)(46)(47)(48).…”

Section: Discussionmentioning

confidence: 99%

Sperm DNA Methylation at Metabolism-Related Genes in Vegan Subjects

et al. 2021

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ObjectiveTo investigate if epigenome of sperm cells could be dynamically affected by nutrition.Design and MethodsWe assessed 40 healthy volunteers with different dietary habits and collected their demographic characteristics, as well as clinical and anthropometric parameters. We compared methylation profiles in sperm quantified by bisulfite pyrosequencing, at promoter-associated CpG sites of genes involved in metabolism including fat mass and obesity-associated (FTO) and melanocortin-4 receptor (MC4R) from six vegans and 34 omnivores. In addition, the FTO rs9939609 (T>A) was genotyped.ResultsHigher DNA methylation levels were detected in the sperm of vegan at FTO gene CpG1 (p=0.02), CpG2 (p=0.001), CpG3 (p=0.004), and CpG4 (p=0.003) sites and at MC4R-CpG2 site [p=0.016] as compared to sperm of omnivores. This association was not related to FTO genotype.ConclusionsAlthough limited by the small number of investigated cases, our data provide insight into the role of diet on sperm DNA methylation in genes involved in metabolism.

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“…In the last decade, numerous studies focusing on establishing a link between nutrition and epigenetics, leaded to the concept of "Precision Nutrition"; a translational approach based on the use of dietary compounds to direct epigenetic changes and drive normal cellular development (Zeisel, 2020). Natural compounds, like vitamins C and D, have been shown to slow pathological processes through their impact on the epigenome (Bunce, Brown et al, 1997, Nur, Rath et al, 2020. Similarly, nutri-epigenomic approaches have been shown to prevent several disease conditions including cancer (Di Tano, Raucci et al, 2020, Meroni, Longo et al, 2020.…”

Section: Introductionmentioning

confidence: 99%

NAD modulates DNA methylation and cell differentiation

Ummarino

Bassal

Zhang

et al. 2020

Preprint

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Nutritional intake impacts the human epigenome by directing epigenetic pathways in normal cell development via as yet unknown molecular mechanisms. Consequently, imbalance in the nutritional intake is able to dysregulate the epigenetic profile and drive cells towards malignant transformation. Herein, we present a novel epigenetic effect of the essential nutrient, NAD. We demonstrate that impairment of DNMT1 enzymatic activity by NAD-promoted ADP-ribosylation, leads to demethylation and transcriptional activation of CEBPA gene, suggesting the existence of an unknown NAD-controlled region within the locus. In addition to the molecular events, NAD treated cells exhibit significant morphological and phenotypical changes that correspond to myeloid differentiation.Collectively, these results delineate a novel role for NAD in cell differentiation and indicate novel nutri-epigenetic strategy to regulate and control gene expression in human cells.

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Nutritive vitamins as epidrugs

Cited by 62 publications

References 105 publications

Genome-Protecting Compounds as Potential Geroprotectors

Genome-Protecting Compounds as Potential Geroprotectors

Sperm DNA Methylation at Metabolism-Related Genes in Vegan Subjects

NAD modulates DNA methylation and cell differentiation

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