Nuts and Bolts of Oil and Temperature in Topical Preparations of Salicylic Acid

Abstract

Citation: Ashara KC, Shah KV. Nuts and bolts of oil and temperature in topical preparations of salicylic acid.Folia Medica 2017;59(3): 279-288. doi: 10.1515/folmed-2017-0034 Background: Traditional formulations of salicylic acid in ointment bases have disadvantages of being greasy and irritant due to free crystals. Aim: To explore the method for selection of oils and their ratio for topical preparation on the basis of equilibrium solubility study of salicylic acid and to evaluate temperature eff ect. Materials and methods: Scanning and calibration curve of salicylic acid in methanol were developed. Among available oils, those that had no interference of absorbance of salicylic acid were short-listed for screening purpose. Selections of oils were carried out on the basis of equilibrium solubility study. Compatibility study was made by Fourier Transform Infra-Red spectroscopy analysis. Primitive study of oil mixtures was done. Selections of the ratio of oils were carried out on basis of constrained simplex-centroid design. Results: Salicylic acid had shown linearity in the range of 15-65 μg/mL in methanol at wavelength maximum (300 nm). From the equilibrium solubility study, Parker Neem® Oil (11.81 ± 0.5 mg/g), Isopropyl Myristate (11.29 ± 0.04 mg/g), Mogra Oil (9.62 ± 0.94 mg/g) were selected. The study possessed the same main Fourier transform infra-red peaks of salicylic acid in the salicylic acid-oils physical mixture. 58.64% Parker Neem® oil and 41.36% isopropyl myristate mixture was selected as optimized batch with the desirability of 0.391. Conclusion:The oils mixture could be selected for topical preparation of salicylic acid like paste, cream, ointment etc. BACKGROUND

Kombi̇ne Sali̇si̇li̇k Asi̇t Ve Povi̇don-İyot İçeren Nanoemüljelleri̇n Hazirlanmasi Ve Karakteri̇zasyonu: Ön Çalişma

“…At the end of 8 hours of the release study, approximately 50% of the SA nanoemulsion was released. However, pure SA solution in methanol showed about 99% release after 2 hours [23]. When compared with our study, it is quite clear that entrapping the SA nanoemulsion in a hydrogel slows the release of SA a little more.…”

“…There are not many studies on the solubility of SA in oils in the literature. Many oils have been tested in the solubility study of SA in oils by Ashara et al [23]. The study was carried out in a shaking incubator at 30 °C for 1 day.…”

Recent Applications of Mixture Designs in Beverages, Foods, and Pharmaceutical Health: A Systematic Review and Meta-Analysis

“…Used to improve solubility of poorly soluble drugs [142]; medicated chewing gums [120]; bioactive dressings [128]; or tablets [121,139], oleogels [144,145], organogels for cardiovascular diseases [118], nanoparticles with amoxicillin trihydrate and thymol [131,134], novel excipients [129,136,146] and oils mixture with salicylic acid for ointment [143] formulation; itraconazole for oral [27,127], gel with loratadine [148], tablets of metformin [130], controlled release of ketoprofen [23] and excipients with finasteride [126] formulation; emulsion formulation of vitamins [119], of aceclofenac [122], of raloxifen [135], of aprepitant [123], of catechin [28], of darunavir [117], of lopinavir [116], of butenafine hydrochloride [132], of cathepsin K inhibitor [140], of telmisartan [138], of olmesartan medoxomil [137], of bovine serum albumin [141], of nelfinavir mesylate [124], of docetaxel [125], of nutraceutical products [147] and oxidative stability avocado oil [133].…”