Nuts and Plasma Lipids: An Almond-Based Diet Lowers LDL-C while Preserving HDL-C

Spiller, Gene A.; Jenkins, David A. J.; Bosello, O; Gates, Joan E.; Cragen, Liz N.; Bruce, Bonnie

doi:10.1080/07315724.1998.10718761

Cited by 180 publications

(137 citation statements)

References 17 publications

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“…However, there were no significant changes in the body weight throughout the study period. None of the well-controlled metabolic-type feeding studies show significant changes in body weight compared to the nut and the nut-free control diet (Abbey et al, 1994;Spiller et al, 1998;Almario et al, 2001;Rajaram et al, 2001;Sabaté, 2003). An inverse relation between frequent nut consumption and BMI has been reported (Garg et al, 2003;Sabaté, 2003).…”

Section: Discussionmentioning

confidence: 99%

“…It is possible that significant reduction in total and LDL cholesterol concentrations in our study may be attained by increased supplementation of hazelnut in the human diet. Spiller et al (1998) reported that adding 100 g of almonds, as MUFA-rich foods, to the diet of hypercholesterolemic volunteers reduced total and LDL cholesterol from 9 to 12% compared with baseline values, respectively. Hazelnut-enriched diet significantly (Po0.05) increased the concentrations of HDL cholesterol by 12.6 and 13.6% compared both with baseline and control diet, respectively.…”

Section: Effects Of Hazelnut-enriched Diet On Plasma Lipid Profiles Smentioning

confidence: 99%

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Effects of hazelnut-enriched diet on plasma cholesterol and lipoprotein profiles in hypercholesterolemic adult men

Mercanlıgil

Arslan

Alasalvar³

et al. 2006

Eur J Clin Nutr

105

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Objective: Frequent consumption of nuts is associated with favorable plasma lipid profiles and reduced risk of coronary heart disease (CHD). This study was conducted to investigate the effects of hazelnut-enriched diet on plasma cholesterol and lipoprotein profiles in hypercholesterolemic adult men compared with baseline and control diet, and also to measure the anthropometric parameters, habitual physical activities, nutrient intake and endothelial function. Subjects and design: Fifteen hypercholesterolemic men aged 4878 years were recruited voluntarily. A well-controlled, 2-period (P 1 and P 2 ) study design with a total of 8-week was implemented. In the P 1 , subjects consumed a control diet (low-fat, low-cholesterol and high-carbohydrate). During the P 2 , the control diet was supplemented with MUFA-rich hazelnut (40 g/day), which provided 11.6% of total energy content. Anthropometric parameters and habitual physical activities were recorded. Plasma total and HDL cholesterol, TAG, ApoA-1, Apo B, total homocysteine and glucose concentrations were measured. All parameters and measurements were obtained at baseline and end of each 4-week diet period. Results: Body weights of subjects remained stable throughout the study. Compared with baseline, the hazelnut-enriched diet decreased (Po0.05) the concentrations of VLDL cholesterol, triacylglycerol, apolipoprotein B by 29.5, 31.8, and 9.2%, respectively, while increasing HDL cholesterol concentrations by 12.6%. Total/HDL cholesterol and LDL/HDL cholesterol ratios favorably decreased (Po0.05). Although insignificant there was a decreasing trend for the rest of parameters, particularly in total (5.2%) and LDL cholesterol (3.3%) in subjects consuming a hazelnut-enriched diet compared to that of the baseline. No changes were found in fasting levels of glucose, Apo A-1 and homocysteine between the control and hazelnut-enriched diets. Conclusions: This study demonstrated that a high-fat and high-MUFA-rich hazelnut diet was superior to a low-fat control diet because of favorable changes in plasma lipid profiles of hypercholesterolemic adult men and, thereby positively affecting the CHD risk profile. Sponsorship:

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Section: Discussionmentioning

confidence: 99%

Section: Effects Of Hazelnut-enriched Diet On Plasma Lipid Profiles Smentioning

confidence: 99%

Effects of hazelnut-enriched diet on plasma cholesterol and lipoprotein profiles in hypercholesterolemic adult men

Mercanlıgil

Arslan

Alasalvar³

et al. 2006

Eur J Clin Nutr

105

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show abstract

“…Another approach that might invigorate current knowledge is the addition of a whole food to the existing diet for the same beneficial effect. Nuts, as whole food, have received particular attention because of the epidemiological association of frequent intake with protection from coronary heart disease (Fraser et al, 1992;Sabaté and Fraser, 1994;Kushi et al, 1996;Hu et al, 1998;Spiller et al, 1998;Hu and Stampfer, 1999). Walnuts have a high fat content, as do other nuts, but are low in saturated fatty acids.…”

Section: Introductionmentioning

confidence: 99%

Long-term walnut supplementation without dietary advice induces favorable serum lipid changes in free-living individuals

et al. 2010

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Background/Objectives: Walnuts have been shown to reduce serum lipids in short-term well-controlled feeding trials. Little information exists on the effect and sustainability of walnut consumption for longer duration in a free-living situation. Subjects/Methods: A randomized crossover design in which 87 subjects with normal to moderate high plasma total cholesterol were initially assigned to a walnut-supplemented diet or habitual (control) diet for a 6-month period, then switched to the alternate dietary intervention for a second 6-month period. Each subject attended seven clinics 2 months apart. At each clinic, body weight was measured, and in five clinics (months 0, 4, 6, 10 and 12), a blood sample was collected. Results: Our study showed that supplementing a habitual diet with walnuts (12% of total daily energy intake equivalent) improves the plasma lipid profile. This beneficial effect was more significant in subjects with high plasma total cholesterol at baseline. Significant changes in serum concentrations of total cholesterol (P ¼ 0.02) and triglycerides (P ¼ 0.03) were seen and nearly significant changes in low-density lipoprotein cholesterol (LDL-C) (P ¼ 0.06) were found. No significant change was detected in either high-density lipoprotein (HDL) cholesterol LDL to HDL ratio. Conclusions: Including walnuts as part of a habitual diet favorably altered the plasma lipid profile. The lipid-lowering effects of walnuts were more evident among subjects with higher lipid baseline values, precisely those people with greater need of reducing plasma total and LDL-C.

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“…Almonds lower serum total cholesterol, LDL cholesterol concentration, and total cholesterol/HDL ratio while preserving HDL cholesterol [109]. Almonds are a great source of fiber, vitamins, and minerals, especially vitamin E and B complex, iron, calcium, potassium, zinc, and magnesium, and are gluten-free.…”

Section: Nutsmentioning

confidence: 99%

Complementary and alternative medicine: Herbals and supplements: A review for the primary care physician

Davuluri¹,

Dharmarajan²

2014

Cureus

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Nuts and Plasma Lipids: An Almond-Based Diet Lowers LDL-C while Preserving HDL-C

Abstract: Results suggest that the more favorable lipid-altering effects induced by the almond group may be due to interactive or additive effects of the numerous bioactive constituents found in almonds.

Cited by 180 publications

References 17 publications

Effects of hazelnut-enriched diet on plasma cholesterol and lipoprotein profiles in hypercholesterolemic adult men

Effects of hazelnut-enriched diet on plasma cholesterol and lipoprotein profiles in hypercholesterolemic adult men

Long-term walnut supplementation without dietary advice induces favorable serum lipid changes in free-living individuals

Complementary and alternative medicine: Herbals and supplements: A review for the primary care physician

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