Nylon cloth macular amyloidosis

Macsween, Rnm; Saihan, E.M.

doi:10.1046/j.1365-2230.1997.1770598.x

Cited by 15 publications

(11 citation statements)

References 4 publications

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“…Similar features of thinning of epidermis, moderate acanthosis and hyperkeratosis, focal distribution of the basal layer with pigmentary incontinence as observed by us have been consistently described. [24273839] Amyloid on H&E stain shows amorphous eosinophilic masses and small deposits of amyloid can be missed with routine H&E stains. [39] Congo red produces an apple green birefringence under a polarizing microscope and is the most specific stain for detection of amyloid.…”

Section: Discussionmentioning

confidence: 99%

“…[24273839] Amyloid on H&E stain shows amorphous eosinophilic masses and small deposits of amyloid can be missed with routine H&E stains. [39] Congo red produces an apple green birefringence under a polarizing microscope and is the most specific stain for detection of amyloid. [319] We observed an increased rate of detection of amyloid with Congo red and polarized light confirming its superiority for staining amyloid on histological sections…”

Section: Discussionmentioning

confidence: 99%

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A clinico-epidemiological study of macular amyloidosis from North India

2012

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Background:Macular amyloidosis (MA) is the most subtle form of cutaneous amyloidosis, characterized by brownish macules in a rippled pattern, distributed predominantly over the trunk and extremities. MA has a high incidence in Asia, Middle East, and South America. Its etiology has yet to be fully elucidated though various risk factors such as sex, race, genetic predisposition, exposure to sunlight, atopy and friction and even auto-immunity have been implicated.Aim:This study attempts to evaluate the epidemiology and risk factors in the etiology of MA.Materials and: Methods:Clinical history and risk factors of 50 patients with a clinical diagnosis of MA were evaluated. Skin biopsies of 26 randomly selected patients were studied for the deposition of amyloid.Results:We observed a characteristic female preponderance (88%) with a female to male ratio of 7.3:1, with a mean age of onset of MA being earlier in females. Upper back was involved in 80% of patients and sun-exposed sites were involved in 64% cases. Incidence of MA was high in patients with skin phototype III. Role of friction was inconclusiveConclusion:Lack of clear-cut etiological factors makes it difficult to suggest a reasonable therapeutic modality. Histopathology is not specific and amyloid deposits can be demonstrated only in a small number of patients. For want of the requisite information on the natural course and definitive etiology, the disease MA remains an enigma and a source of concern for the suffering patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A clinico-epidemiological study of macular amyloidosis from North India

2012

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“…This suggests that genetic, environmental and even cultural factors may be implicated in PCA. 7 This type of amyloidosis is more frequent in females, particularly those in the 21-to 50-year age range, suggesting that hormonal factors may be involved in the etiopathogenesis of the disease. 2 The patient described here is South American and lies in this age range.…”

Section: Discussionmentioning

confidence: 99%

Amiloidose macular de localização atípica

Melo

Costa

et al. 2011

An. Bras. Dermatol.

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Macular amyloidosis is a form of cutaneous amyloidosis characterized by dusky-brown lesions usually located on the upper back between the shoulder blades. This report describes the case of a 45-year-old female presenting with hyperpigmented macules and lace-like, non-pruritic erythema in the sacral and cervical region as well as on both arms and legs. Histology revealed amyloid deposits in the papillary dermis which exhibited apple-green birefringence after Congo red staining. There were no systemic findings. This is a case of macular amyloidosis with an unusual presentation. The literature on the subject is also reviewed. Keywords: Amyloidosis; Congo Red; Hyperpigmentation Resumo: A amiloidose macular é uma forma cutânea primária de amiloidose, caracterizada tipicamente por máculas acastanhadas, acometendo predominantemente a região interescapular. O presente caso é o de uma mulher de 45 anos, há um ano com manchas hipercrômicas, rendilhadas e não pruriginosas, em membros superiores, região cervical, sacral e membros inferiores. No estudo histopatológico da biópsia de pele, foi evidenciada substância amiloide amorfa no topo das papilas dérmicas, que se tornou mais evidente após a coloração pelo vermelho Congo. Não havia alterações sistêmicas associadas. Além da localização atípica e extensa da amiloidose cutânea macular, o presente caso procura acrescentar dados para esclarecimento do tema.

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“…"friction amyloidosis" am Rücken durch Nylonbürsten oder -tücher beschrieben ist [6,9,10,16]. "friction amyloidosis" am Rücken durch Nylonbürsten oder -tücher beschrieben ist [6,9,10,16].…”

Section: Ablagerung Von Amyloid Durch Kratzen Und Scheuernunclassified