O-006 Expansion of Immunologically-Relevant E. Coli in the Intestinal Microbiota of Patients with IBD-Associated Spondyloarthritis Promotes Mucosal RORgt-Dependent Immunity

Kivolowitz, Charles; Abdulhamid, Ahmed; Victorio, Daniel; Castellanos, Jim G.; Simpson, Kenneth W.; Scherl, Ellen; Longman, Randy S.

doi:10.1097/01.mib.0000480044.73384.2d

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T a B L E 4 Association Of Tfrsf1a1

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2017

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“…AS and RA are different diseases, have different mechanisms and our results may offer a crucial supplement for AS genetic diagnosis . TNF blockers have been proven to be highly effective in reducing Spondyloarthritis (SpA) and inflammatory bowel diseases (IBDs) . Currently, there are a few TNF‐α inhibitors available for clinical treatments.…”

Section: Discussionmentioning

confidence: 99%

“…38 TNF blockers have been proven to be highly effective in reducing Spondyloarthritis (SpA) and inflammatory bowel diseases (IBDs). 39,40 Currently, there are a few TNFα inhibitors available for clinical treatments. These inhibitors act to block the binding of TNFα to its receptors and therefore, interfering with TNFα signaling T A B L E 1 1 Association between TFRSF1A haplotypes and tradition treatment for AS (primarily to its soluble form) with a high affinity and blocks the effects of TNF.…”

Section: T a B L E 4 Association Of Tfrsf1amentioning

confidence: 99%

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