O-025. Effects of chlorinated hydrocarbons on the acrosome reaction of human spermatozoa in vitro

Pflieger-Bruss, S.; Hagemann, Sandra; Heitkamp, S.; Köhn, F.‐M.; Körner, Wolfgang; Hanf, Volker; Schill, W.‐B.

doi:10.1093/humrep/14.suppl_3.14

Cited by 5 publications

(6 citation statements)

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“…After human spermatozoa had been exposed to different single PCB congeners during capacitation, the spontaneous acrosome reaction was determined. No significant differences were found between PCB‐exposed spermatozoa and the control group (Pflieger‐Bruss et al. , 1999a).…”

Section: Chlorinated Hydrocarbonsmentioning

confidence: 81%

“…, 1989). Data from our own laboratory suggest that very high concentrations of PCB 77, 126, 153 and 118 do not affect the motility and vitality of human spermatozoa in vitro (Pflieger‐Bruss et al. , 1999a).…”

Section: Chlorinated Hydrocarbonsmentioning

confidence: 99%

“…, 1974), temperature (Jung et al. , 2001), stress, environmental chemicals (Pflieger‐Bruss et al. , 1999a), nicotine (Marshburn et al.…”

Section: Introductionmentioning

confidence: 99%

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The male reproductive system and its susceptibility to endocrine disrupting chemicals

2004

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Summary. In the past years, there has been increased interest in assessing the relationship between impaired male fertility and environmental factors. Human male fertility is a complex process and therefore a great variety of sites may be affected by exogenous noxae. Lifestyle factors as well as various environmental and occupational agents may impair male fertility. Many studies have been published reporting on reproductive dysfunctions in male animals and humans. Especially environmental pollutants with endocrine activity are discussed as a possible cause of this detrimental development. Evidence from animal experiments show that substances with oestrogenic and antiandrogenic properties may cause hypospadia, cryptorchidism, reduction of sperm density and an increase of testicular tumours. Many adverse effects on animal male fertility have been documented for phthalates and some chlorinated hydrocarbons such as polychlorinated biphenyls and polychlorinated dibenzo‐p‐dioxins. For other chemicals such as bisphenol A and nonylphenols animal data are conflicting. Environmental pollutants may mediate their effects by receptor binding, modulation of hormone‐regulated mechanisms or direct toxic effects. Data on environmental chemicals and human male fertility are scarce, and risk assessment is mostly based on the results of animal studies. However, there are indications that exposure to endocrine active chemicals during early development may alter hormone responsiveness in adulthood. Furthermore, some of the chemicals are found in fluids that are associated with human reproduction, such as follicular fluid, seminal fluid and cervical mucus. Recent studies suggest a correlation between pesticide exposure and standard semen parameters as well as in vitro fertilization rates.

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Section: Chlorinated Hydrocarbonsmentioning

confidence: 81%

Section: Chlorinated Hydrocarbonsmentioning

confidence: 99%

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The male reproductive system and its susceptibility to endocrine disrupting chemicals

2004

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“…Additionally, induction of the acrosome reaction was reported ( Roediger et al ., 1989 ). Data from our own laboratory suggest that very high concentrations (2.5–20 μg ml −1 ) of PCB 77, 126, 153 and 118 do not affect motility and vitality of human spermatozoa in vitro ( Pflieger‐Bruss et al ., 1999b ). After human spermatozoa had been exposed to different single PCB congeners during capacitation, the spontaneous acrosome reaction was determined.…”

Section: Sperm Function and Chlorinated Hydrocarbonsmentioning

confidence: 99%

Effects of chlorinated hydrocarbons on sperm function in vitro

Pflieger-Bruss

Schill

2000

Andrologia

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For the past few years there has been controversial discussion of whether environmental pollutants in general, and chlorinated hydrocarbons in particular, may impair male fertility. Organochlorine compounds, e.g. dichlorodiphenyltrichlorothane (DDT) and metabolites, polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) are highly persistent in the environment and there is therefore some concern about human exposure. These chlorinated compounds are universally found in human body fluids. Substantial amounts are detected in human body fluids associated with reproduction such as follicular fluid, seminal fluid and cervical mucus. The available data on male fertility and organochlorines are scarce and controversial. Fertilization rates in in vitro fertilization procedures were found to be decreased in couples in whom the male partner was exposed to pesticides. Data on the effects of PCBs on human sperm motility and acrosome reaction in vitro are controversial. Various PCDD congeners had no effect on human sperm motility in vitro. Effects of chlorinated hydrocarbons on sperm function in vivo seem to be unlikely since the concentrations used in vitro were far higher than those found in fluids of the human reproductive tract. However, negative effects on human spermatozoa in vivo cannot be totally excluded because other organohalogen compounds can be identified in the genital tract and little is known about their synergistic effects.

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“…Die Motilität der Mäusespermatozoen war nach Inkubation mit 1 und 10 µg/ml Aroclor 1254 nicht beeinträchtigt. Die Inkubation humaner kapazitierender Spermatozoen mit unterschiedlichen Konzentrationen einzelner PCB-Kongenere (PCB 77, PCB 126, PCB 118 und PCB 153) beeinflusst die spontane und induzierte akrosomale Reaktion und die Spermatozoenmotilität nicht [20].…”

Section: Chlorierte Kohlenwasserstoffeunclassified