2014
DOI: 10.1016/s1873-9946(14)50088-8
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O-22: Partial enteral nutrition with a Crohn’s disease exclusion diet (CDED) is effective for induction of remission in children and young adults with mild to moderate Crohn’s disease

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Cited by 47 publications
(81 citation statements)
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“…Recent studies using formula based therapies have amended standard EEN with the addition of dietary foods. 12 We, as well as others, have shown diet itself may be able to modify both inflammatory processes and symptoms in Crohn's disease. 9,10 Dietary therapy in the form of SCD has been integrated into our clinical practice for those patients and patient families invested in trying a monitored nutritionbased therapy with clearly outlined goals including clinical remission and growth improvement.…”
Section: Comparative Analysismentioning
confidence: 89%
See 1 more Smart Citation
“…Recent studies using formula based therapies have amended standard EEN with the addition of dietary foods. 12 We, as well as others, have shown diet itself may be able to modify both inflammatory processes and symptoms in Crohn's disease. 9,10 Dietary therapy in the form of SCD has been integrated into our clinical practice for those patients and patient families invested in trying a monitored nutritionbased therapy with clearly outlined goals including clinical remission and growth improvement.…”
Section: Comparative Analysismentioning
confidence: 89%
“…11 Since our initial report of efficacy of the SCD, further studies showing efficacy of dietary intervention have been reported. 10,12 Based upon emerging data, M A N U S C R I P T…”
Section: Introductionmentioning
confidence: 99%
“…This diet was evaluated initially in 47 children and adults with mild-to-moderate disease. Clinical remission was achieved in 70% of patients; this was accompanied by a significant drop in ESR and CRP and was associated with mucosal healing among patients who achieved remission and were evaluated during the maintenance phase of the diet 77. The diet is low in animal fat, rich in complex carbohydrates, with moderate exposure to soluble fibre.…”
Section: Introductionmentioning
confidence: 99%
“…who similarly prescribed 50% of energy intake as liquid formula but requested that patients follow a structured ‘Crohn’s disease exclusion diet’ with specific foods excluded as opposed to an unrestricted one. In their study, higher rates of remission were noted, with 72% of patients entering remission assessed by the PCDAI, although patients with mild‐moderate disease were more likely to respond that those with severe disease ( P < 0.05) The final study reviewed applied a higher percentage of the EAR as liquid formula with patients being prescribed 80–90% EAR, infused via NGT overnight and allowed the remaining 10–20% EAR from solid food during the day. Overall, 65% achieved clinical remission by week 8, with a further 22% demonstrating a clinically significant response …”
Section: Resultsmentioning
confidence: 99%
“…However, unfortunately, mixed results were seen. In the strongest of these studies, using 50% of EAR with formula in addition to a free diet was shown to have some clinical benefit in terms of improved well‐being and weight gain, although it did not suppress intestinal inflammation, with only 15% of patients entering remission by the end of therapy It is worth noting, however, that only patients with moderate‐severe disease were included, and a subsequent study treating patients mostly with mild‐moderate disease found much higher remission rates (70%) on a PEN protocol similarly providing 50% EAR as liquid formula and 50% as free diet…”
Section: Discussionmentioning
confidence: 99%