O-221. Laser-assisted hatching at the extremes of the IVF spectrum: first cycle and after 6 cycles; a randomized prospective trial

Antinori, S.; Versaci, C.; Dani, Lara; Barbara, E.; Antinori, Monica; Cerusico, C.; Vidali, Andrea

doi:10.1093/humrep/14.suppl_3.122-a

Cited by 5 publications

(1 citation statement)

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“…These studies were published between 1992 and 2014. Of these studies, eight studies were conducted in the USA 5 6 7 8 9 10 11 12 , five studies each in China 13 14 15 16 17 and Turkey 18 19 20 21 22 , three studies each in Brail 23 24 25 and Italy 26 27 28 , two studies each in Iran 29 30 and Israel 31 32 , and one study each in Canada 33 , Germany 34 , Egypt 35 , Switzerland 36 , the Czech Republic 37 , Japan 38 , Australia 39 , and Belgium 40 . Women received either in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI) were observed in fourteen, nine, and seven studies, respectively.…”

Section: Resultsmentioning

confidence: 99%

Effect of assisted hatching on pregnancy outcomes: a systematic review and meta-analysis of randomized controlled trials

Yang

et al. 2016

Sci Rep

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Emerging evidence suggests that assisted hatching (AH) techniques may improve clinical pregnancy rates, particularly in poor prognosis patients; however, there still remains considerable uncertainty. We conducted a meta-analysis to verify the effect of AH on pregnancy outcomes. We searched for related studies published in PubMed, Web of Science, and Cochrane library databases from start dates to October 10, 2015. Totally, 36 randomized controlled trials with 6459 participants were included. Summary odds ratios (ORs) with 95% confidence intervals (CIs) for whether by AH or not were estimated. We found a significant increase in clinical pregnancy (OR = 1.16, 95% CI = 1.00–1.36, I2 = 48.3%) and multiple pregnancy rates (OR = 1.50, 95% CI = 1.11–2.01, I2 = 44.0%) with AH when compared to the control. Numerous subgroup analyses stratified by hatching method, conception mode, extent of AH, embryos transfer status, and previous failure history were also carried out. Interestingly, significant results of clinical pregnancy as well as multiple pregnancy rates were observed among women who received intracytoplasmic sperm injection, and who received AH which the zona were completely removed. In summary, this meta-analysis supports that AH was associated with an increased chance of achieving clinical pregnancy and multiple pregnancy. Whether AH significantly changes live birth and miscarriage rates needs further investigations.

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Section: Resultsmentioning

confidence: 99%

Effect of assisted hatching on pregnancy outcomes: a systematic review and meta-analysis of randomized controlled trials

Yang

et al. 2016

Sci Rep

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Assisted hatching in assisted reproduction: a state of the art

Hammadeh

Fischer-Hammadeh

Ali

2010

J Assist Reprod Genet

106

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The World Health Organization estimates that one in six couples experience some delay in conception and an increasing number require treatment by the assisted conception (AC) procedures of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI).The implantation rate of embryos resulting from in vitro fertilization cycles is generally less than 20%. The exposure of oocytes and embryos to the artificial conditions of in vitro culture may have negative effects on the embryo's ability to undergo normal hatching, resulting in low rates of implantation following IVF and embryo transfer. Human embryos resulting from superovulation develop more slowly in vitro compared to embryos in vivo, manifest a relatively high degree of cytogenetic abnormalities and undergo cellular fragmentation. Artificially disrupting the zona pellucida is known as assisted hatching (AH) and there is some evidence that embryos that have undergone zona manipulation for assisted hatching tend to implant one day earlier than unhatched embryos. A variety of techniques have since been employed to assist embryo hatching, including partial mechanical zona dissection, zona drilling and zona thinning, making use of acid tyrodes, proteinases, piezon vibrator manipulators and lasers. This review will consider the impact of IVF conditions on zona pellucida physiology, zona hardening, different techniques of assisted hatching, who may benefit from assisted hatching and potential hazards.

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Laser assisted zona hatching: What’s the evidence to justify its use?

Helw¹

2011

Middle East Fertility Society Journal

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O-221. Laser-assisted hatching at the extremes of the IVF spectrum: first cycle and after 6 cycles; a randomized prospective trial

Cited by 5 publications

References 0 publications

Effect of assisted hatching on pregnancy outcomes: a systematic review and meta-analysis of randomized controlled trials

Effect of assisted hatching on pregnancy outcomes: a systematic review and meta-analysis of randomized controlled trials

Assisted hatching in assisted reproduction: a state of the art

Laser assisted zona hatching: What’s the evidence to justify its use?

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