2020
DOI: 10.3390/cells9030741
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O-acetylated Gangliosides as Targets for Cancer Immunotherapy

Abstract: O-acetylation of sialic acid residues is one of the main modifications of gangliosides, and modulates ganglioside functions.O-acetylation of gangliosides is dependent on sialyl-O-acetyltransferases and sialyl-O-acetyl-esterase activities. CAS1 Domain-Containing Protein 1 (CASD1) is the only human sialyl-O-acetyltransferases (SOAT) described until now. O-acetylated ganglioside species are mainly expressed during embryonic development and in the central nervous system in healthy adults, but are re-expressed duri… Show more

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Cited by 40 publications
(25 citation statements)
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“…Some O -acetylated gangliosides, which are transiently expressed during development, reemerge during tumorigenesis and can be used as tumor markers [ 56 ]. GM3 is expressed in melanoma, but not in normal melanocytes [ 57 ].…”
Section: Sphingolipids In Cancermentioning
confidence: 99%
“…Some O -acetylated gangliosides, which are transiently expressed during development, reemerge during tumorigenesis and can be used as tumor markers [ 56 ]. GM3 is expressed in melanoma, but not in normal melanocytes [ 57 ].…”
Section: Sphingolipids In Cancermentioning
confidence: 99%
“…O -acetylated GD2 has recently received significant attention as a novel antigen to target GD2-positive cancers. O AcGD2 is highly expressed by GD2-positive tumors such as sarcomas, neuroblastomas, gliomas, and in small cell lung cancer and breast cancer cells [ 59 , 60 ]. GD2 has been considered for more than two decades as a tumor-associated antigen and a highly valuable therapeutic target in these cancers.…”
Section: Expression and Roles Of Cancer-associated Ganglioside In Malignant Propertiesmentioning
confidence: 99%
“…Thus, 9- O -Ac-GD3 is considered a marker of neuroblastoma, melanoma, and breast cancer, whereas acetylated GD2 has been revealed in neuroblastoma, glioblastoma, lung tumours, etc. [ 112 ]. 8B6 monoclonal antibody targeted O -acetylated GD2 has been demonstrated to reduce glioblastoma cell growth in vitro and in vivo [ 113 ] and to increase temozolomide efficacy toward glioblastoma stem cells [ 114 ].…”
Section: Employment Of Glycosphingolipids In Immunotherapy Against Cancermentioning
confidence: 99%