O conduto valvulado bovino contegra, um biomaterial para o tratamento cirúrgico de cardiopatias congênitas

Yuan, Shi‐Min

doi:10.1590/s0066-782x2012005000105

Cited by 12 publications

(2 citation statements)

References 33 publications

(85 reference statements)

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“…В систематическом обзоре 2012 г. S.-M. Yuan проанализировал более 1 700 случаев применения кондуита Contegra за 10 лет и показал его преимущества не только со стороны низкой частоты стенозирования в отдаленном периоде, но и низкой частоты развития значимой недостаточности на собственном клапане. При этом в анализ включены случаи использования участка Contegra в качестве моностворчатого клапана [25].…”

Section: Discussionunclassified

Bovine monocusp in surgery for tetralogy of Fallot

Свободов¹,

Левченко²,

Неталиева³

et al. 2020

PKiK

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Aim. To evaluate the functionality of a bovine monocusp in surgery for tetralogy of Fallot.Methods. We analyzed the results of surgical treatment in the early postoperative period in eight infants and one year after surgery in seven infants (age range, 0–12 months; mean weight = 7.5 ± 2.3 kg). We used echocardiography to evaluate the residual pressure gradient between the right ventricle and the pulmonary artery, the degree of regurgitation on the pulmonary valve after surgery and to calculate Z-score and the fibrous ring diameter of the pulmonary valve in the late follow-up period. The degree of insufficiency was assessed by the width and depth of the regurgitation flow using the color Doppler mode.Results. The pressure gradient on the eve of discharge did not exceed 25 mmHg for any patient. Pulmonary valve regurgitation was mild in four patients and moderate in the remaining patients. Seven children passed the observation one year after surgery. In one case, we discovered a right ventricle outflow tract obstruction. In other cases, the systolic pressure gradient did not exceed 25 mmHg. Four patients in the late follow-up period had severe valve regurgitation. Despite such valve insufficiency, the leaflet mobility in the bovine jugular vein patch was normal.Conclusion. Early postoperative results for reconstructive surgery to repair tetralogy of Fallot with a bovine monocusp were promising. However, long-term results are comparable with those using other materials. The mobility of the native leaflet remains full even a year after surgery. Consequently, we have positive prospects in material improvement for making patches with native monocusps.Received 14 May 2020. Revised 8 June 2020. Accepted 10 June 2020.Funding: The study did not have sponsorship.Conflict of interest: Authors declare no conflict of interest.Author contributions Conception and study design: A.A. Svobodov, E.G. Levchenko, V.T. Kostava Data collection and analysis: G.S. Netalieva, M.V. Zelivyanskaya Statistical analysis: E.G. Levchenko, M.V. Zelivyanskaya Drafting the article: A.A. Svobodov, V.S. Rasumovsky Critical revision of the article: V.S. Rasumovsky Final approval of the version to be published: A.A. Svobodov, E.G. Levchenko, G.S. Netalieva, V.T. Kostava, M.V. Zelivyanskaya, V.S. Rasumovsky

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Section: Discussionunclassified

Bovine monocusp in surgery for tetralogy of Fallot

Свободов¹,

Левченко²,

Неталиева³

et al. 2020

PKiK

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“…Bioprosthetic valves made of bovine pericardium with chemical modifications have become widely accepted as artificial bioprosthetic valves because of their good durability ( 5 , 6 , 9 ). Nevertheless, there is a risk of hyperacute and acute rejection or vascular injury of the xenogeneic tissues.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of a novel, completely biomaterial valved pulmonary arterial conduit: An in�vivo study

Ren

Duan

et al. 2020

Exp Ther Med

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As a pre-clinical assessment, the present study aimed to investigate the safety and effectiveness of a novel valved pulmonary arterial conduit constructed entirely from biomaterials by transplanting it in the outflow tract of the right ventricle in sheep. Under extracorporeal circulation, the valved pulmonary arterial conduit was used to replace the pulmonary artery of sheep with a beating heart. The performance was assessed at 30, 90 and 180 days post-surgery. Hemodynamic and structural changes were evaluated, and safety was assessed after 180 postoperative days. The hemodynamic effect and biosafety of the implant were further evaluated by observing the changes in various pressure indicators of the heart, echocardiographic results, anatomical and pathological examination results, liver and kidney functions, routine blood tests, a blood coagulation test, and other test results following implantation of the purely biotic valved conduit. The conduit was successfully implanted in 12 sheep and no mortality occurred postoperatively. During the 180-day follow-up, there was no obvious stenosis or regurgitation of the right ventricular outflow tract and pulmonary valve after valved conduit implantation. The findings of autopsy, pathology and laboratory examinations were unremarkable. The implantation of this biosynthetic vascular graft into animals meets the safety and effectiveness requirements for clinical application. This pulmonary arterial conduit has potential clinical application for children with complex congenital heart disease who require pulmonary artery reconstruction to achieve a radical cure.

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Handmade tri-leaflet ePTFE conduits versus homografts for right ventricular outflow tract reconstruction

Wang

Mao

et al. 2022

World J Pediatr

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O conduto valvulado bovino contegra, um biomaterial para o tratamento cirúrgico de cardiopatias congênitas

Cited by 12 publications

References 33 publications

Bovine monocusp in surgery for tetralogy of Fallot

Bovine monocusp in surgery for tetralogy of Fallot

Effectiveness of a novel, completely biomaterial valved pulmonary arterial conduit: An in�vivo study

Handmade tri-leaflet ePTFE conduits versus homografts for right ventricular outflow tract reconstruction

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