O epitélio respiratório em ratos Wistar nascidos em ruído de baixa frequência e expostos a ruído adicional

Branco, N. A. A. Castelo; Monteiro, Eliseu; Silva, António Costa e; Ferreira, J.M. Reis; Alves-Pereira, Mariana

doi:10.1016/s0873-2159(15)30702-9

Cited by 10 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is a lack of studies on the effect of LFN on the human respiratory system; however, there is evidence from animal studies. 29 30 31 The respiratory cilia are composed of tubulin, and they are anchored to the actin cytoskeleton (CSK). With prolonged exposure to LFN, these cilia become shaggy, sheared, and clipped.…”

Section: Introductionmentioning

confidence: 99%

Audiological, Phonatory and Cardiac Correlates of Individuals Exposed to Low-Frequency Noise or at Risk of Vibroacoustic Disease

Verma

Shah²,

Singh³

et al. 2022

Int Arch Otorhinolaryngol

View full text Add to dashboard Cite

Introduction Low-frequency noise (LFN) is hazardous to hearing. Long-term exposure to LFN may lead to vibroacoustic disease (VAD), which not only affects a specific organ but the physiological function of entire systems, such as the auditory, phonatory, respiratory, and cardiac systems. Moreover, VAD may lead to many psychological problems and hence affect the quality of life. Objective To investigate the adverse effects of LFN on hearing, acoustic and perceptual correlates of the voice, blood pressure, cardiac rate, and anxiety level. Method A total of 20 subjects exposed to LFN and 20 not exposed to LFN were included, and a detailed case history was recorded. The patients were submitted to pure tone audiometry, otoscopic examination, acoustic and perceptual analyses of the voice, maximum phonation time, and an assessment of the s/z ratio. We also assessed blood pressure, and the results of a voice-related quality of life questionnaire and of the Hamilton anxiety rating scale. Results The results indicate that LFN had an adverse impact on the high-frequency threshold. The present study found a significant difference in shimmer and harmonics-to-noise ratio (HNR) values. Few subjects had high blood pressure and showed the sign of anxiety on the Hamilton anxiety rating scale. Conclusion Low-frequency noise has adverse effects on entire systems of the body and causes many psychological issues, which, in turn negatively affect quality of life.

show abstract

Section: Introductionmentioning

confidence: 99%

Audiological, Phonatory and Cardiac Correlates of Individuals Exposed to Low-Frequency Noise or at Risk of Vibroacoustic Disease

Verma

Shah²,

Singh³

et al. 2022

Int Arch Otorhinolaryngol

View full text Add to dashboard Cite

show abstract

Vibroacoustic disease: Biological effects of infrasound and low-frequency noise explained by mechanotransduction cellular signalling

Alves-Pereira

Branco²

2007

Progress in Biophysics and Molecular Biology

View full text Add to dashboard Cite

At present, infrasound (0-20 Hz) and low-frequency noise (20-500 Hz) (ILFN, 0-500 Hz) are agents of disease that go unchecked. Vibroacoustic disease (VAD) is a whole-body pathology that develops in individuals excessively exposed to ILFN. VAD has been diagnosed within several professional groups employed within the aeronautical industry, and in other heavy industries. However, given the ubiquitous nature of ILFN and the absence of legislation concerning ILFN, VAD is increasingly being diagnosed among members of the general population, including children. VAD is associated with the abnormal growth of extra-cellular matrices (collagen and elastin), in the absence of an inflammatory process. In VAD, the end-product of collagen and elastin growth is reinforcement of structural integrity. This is seen in blood vessels, cardiac structures, trachea, lung, and kidney of both VAD patients and ILFN-exposed animals. VAD is, essentially, a mechanotransduction disease. Inter- and intra-cellular communication is achieved through both biochemical and mechanotranduction signalling. When the structural components of tissue are altered, as is seen in ILFN-exposed specimens, the mechanically mediated signalling is, at best, impaired. Common medical diagnostic tests, such as EKG, EEG, as well as many blood chemistry analyses, are based on the mal-function of biochemical signalling processes. VAD patients typically present normal values for these tests. However, when echocardiography, brain MRI or histological studies are performed, where structural changes can be identified, all consistently show significant changes in VAD patients and ILFN-exposed animals. Frequency-specific effects are not yet known, valid dose-responses have been difficult to identify, and large-scale epidemiological studies are still lacking.

show abstract

O aparelho respiratório na doença vibroacústica: 25 anos de investigação

Branco

Ferreira

Alves-Pereira

2007

Revista Portuguesa de Pneumologia

View full text Add to dashboard Cite

O epitélio respiratório em ratos Wistar nascidos em ruído de baixa frequência e expostos a ruído adicional

Cited by 10 publications

References 7 publications

Audiological, Phonatory and Cardiac Correlates of Individuals Exposed to Low-Frequency Noise or at Risk of Vibroacoustic Disease

Audiological, Phonatory and Cardiac Correlates of Individuals Exposed to Low-Frequency Noise or at Risk of Vibroacoustic Disease

Vibroacoustic disease: Biological effects of infrasound and low-frequency noise explained by mechanotransduction cellular signalling

O aparelho respiratório na doença vibroacústica: 25 anos de investigação

Contact Info

Product

Resources

About