O-glycans Expand Lubricin and Attenuate its Viscosity and Shear Thinning
Saber Boushehri,
Hannes Holey,
Matthias Brosz
et al.
Abstract:Lubricin, an intrinsically disordered glycoprotein, plays a pivotal role in facilitating smooth movement and ensuring the enduring functionality of synovial joints. The central domain of this protein serves as a source of this excellent lubrication, and is characterized by its highly glycosylated, negatively charged, and disordered structure. However, the influence of O-glycans on the viscosity of lubricin remains unclear. In this study, we employ molecular dynamics simulations in absence and presence of shear… Show more
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