Management of students' research activities in recent years has been following the principles of project management, which involves the inclusion of project lifecycle management models. The aim is to determine the possibilities of using project lifecycle management models based on the Project Management Institute Project Management Body of Knowledge-6 methods in the research projects made by students receiving higher pharmaceutical education. The models under study are rigid (cascade, iterative, V-model) and flexible models (Agile models, AZ model). The assessment was carried out by 19 experts in the fields of knowledge of the Six-Pointed Star Project Management Body of Knowledge model according to the Likert scale. It has been established that rigid and flexible models can be selectively applied in the research of junior and senior students, depending on the priority of individual areas of knowledge of the Six-Pointed Star Project Management Body of Knowledge model and the scale of work. Among rigid models, the iterative model and the V-model were better than the cascade model in some areas of knowledge and at a certain scale of the research project. Among flexible models, Agile models outperformed the AZ model in terms of time and cost, and the AZ model was better than Agile models in terms of quality and risk. The preferential opportunities for the application of project lifecycle management models in the students' research projects in each of the fields of knowledge of the Six-Pointed Star Project Management Body of Knowledge model have been shown. For a more detailed study of the process of choosing a project lifecycle management model for students' research projects, it is necessary to create an algorithm for this process.