O polimorfismo AGT*M235T na disfunção cardíaca de etiologia isquêmica aguda: projeto gisca

Saud, Claudia Guerra Murad; Reis, Amália Faria dos; Dias, Arlisa Monteiro de Castro; Cardoso, Rosemery Nunes; Carneiro, Ana Cristina Klem Vargas; Souza, Leandro Pereira de; Fonseca, Ana Beatriz Monteiro; Ribeiro, Georgina Severo; Faria, Carlos Augusto

doi:10.1590/s0066-782x2010005000070

Cited by 2 publications

(1 citation statement)

References 32 publications

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“…Pre-eclampsia Vasoconstriction and dysregulation of salt and water homeostasis [110] Diabetic Nephropathy Increased peripheral and renal resistance, proteinuria and oxidative stress lead to endothelial damage [111] Acute Ischemic Cardiac Dysfunction Modification of extracellular matrix and myocytes in the heart [112] Heart Failure Sodium retention, myocardial fibrosis and vasoconstriction [113] Hypertrophic Cardiomyopathy Angiotensin II exerts positive inotropic, apoptotic and hypertrophic effects [114] Ischemic Stroke Activation of vascular cell apoptosis, and vasoconstriction [115] Chronic Heart Disease (CHD) Increased vasoconstriction and sodium retention leads to hypertension which promotes the progression of CHD [116] Myocardial Infarction Cardiac fibrosis, collagen synthesis and modified growth of cardiac fibroblast led to the development of atherosclerosis [117] Obesity and dyslipidemia Upregulation of lipid synthesis through AT II receptors and downregulation of lipolysis through AT I receptors [48,118] Depression Increased plasma level of AGT produces increased corticotrophin releasing factor which stimulates the hypothalamic-pituitary-adrenal, regulation of norepinephrine, increased release of cytokines, and inhibition of neurogenesis process [119,120] AGT G-217A…”

Section: Agt M235tmentioning

confidence: 99%

Genetic Polymorphism in Angiotensinogen and Its Association with Cardiometabolic Diseases

et al. 2022

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Angiotensinogen (AGT) is one of the most significant enzymes of the renin-angiotensin-aldosterone system (RAAS) which is involved in the regulation and maintenance of blood pressure. AGT is involved in the production of angiotensin I which is then converted into angiotensin II that leads to renal homeostasis. However, various genetic polymorphisms in AGT have been discovered in recent times which have shown an association with various diseases. Genetic polymorphism increases the level of circulating AGT in blood which exaggerates the effects produced by AGT. The associated diseases occur due to various effects produced by increased AGT levels. Several cardiovascular diseases including myocardial infarction, coronary heart disease, heart failure, hypertrophy, etc. are associated with AGT polymorphism. Other diseases such as depression, obesity, diabetic nephropathy, pre-eclampsia, and liver injury are also associated with some variants of AGT gene. The most common variants of AGT polymorphism are M235T and T174M. The two variants are associated with many diseases. Some other variants such as G-217A, A-6G, A-20C and G-152A, are also present but they are not as significant as that of M235T and T174M variants. These variants increase the level of circulating AGT and are associated with prevalence of different diseases. These diseases occur through various pathological pathways, but the initial reason remains the same, i.e., increased level of AGT in the blood. In this article, we have majorly focused on how genetic polymorphism of different variants of AGT gene is associated with the prevalence of different diseases.

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