O<scp>ral</scp> L<scp>ichen</scp> P<scp>lanus and</scp> M<scp>alignant</scp> T<scp>ransformation</scp>: I<scp>s a</scp> R<scp>ecall of</scp> P<scp>atients</scp> J<scp>ustified</scp>?

Mattsson, Ulf; Jontell, Mats; Holmstrup, Palle

doi:10.1177/154411130201300503

Cited by 142 publications

(52 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our study, complete remission was observed in 66.7% (n=10) and partial remission in 33.4% (n=5) of patients after eight weeks of treatment with prednisolone 40 mg/day along with tapered doses, which was more or less similar to the results reported by Carbone M et al [24] A double blind placebo controlled randomized clinical trial conducted by Saawar N et al [6] transformation (up to 0.2-2%) as compared to another forms. [25,26] Therefore, it may be presumed that lycopene and prednisolone may decrease the risk of malignant transformation in OLP.…”

Section: Discussionmentioning

confidence: 99%

Comparative Study of the Efficacy of Lycopene Versus Prednisolone in the Management of Oral Lichen Planus- A Randomized, Double Blind Clinical Trial.

Kushwaha¹

2017

WJPPS

View full text Add to dashboard Cite

Oral lichen planus (OLP) is a chronic inflammatory, immunologically mediated mucocutaneous disorder. Numerous topical and systemic therapies have been used in the treatment of OLP. Most of the current available treatments are palliative rather than curative. Corticosteroids are considered as the main treatment drugs. Unfortunately, some patients may develop refractory or resistance to corticosteroids therapy. This study aims to evaluate and compare the efficacy of lycopene and prednisolone in the management of OLP. This was a double-blind randomized comparative study in which clinically and histopathologically proven symptomatic OLP patients were enrolled and divided into two groups. Lycopene group received oral lycopene 4 mg/day (n=13) and prednisolone group received oral prednisolone 40 mg/day (n=15) for eight consecutive weeks. Assessments were made at baseline and after 2, 4, 6 and 8 weeks of treatment, based on the Numerical Rating Scale (NRS) and the Piboonniyom REU (Reticular, Erythematous and Ulceration) severity score. From the results obtained, the reduction of NRS burning sensation scores was statistically significant after two weeks of treatment in both groups. REU severity scores were decreased by 74% (p=0.005) and 91% (p=0.001) in lycopene and prednisolone groups respectively. Complete remission (EI=100%) of lesion was observed in two (15.4%) patients treated with lycopene and ten (66.7%) patients treated with prednisolone. However, the overall treatment response was

show abstract

Section: Discussionmentioning

confidence: 99%

Comparative Study of the Efficacy of Lycopene Versus Prednisolone in the Management of Oral Lichen Planus- A Randomized, Double Blind Clinical Trial.

Kushwaha¹

2017

WJPPS

View full text Add to dashboard Cite

show abstract

“…The rate of malignant potential has been controversial, possibly due to a wide range of reported incidences of 0%-12.5% (16,17). Further studies are needed to better predict OLP patients who are at risk of developing oral squamous cell carcinoma (OSCC).…”

Section: Discussionmentioning

confidence: 99%

“…The malignancy of OLP has been controversial with malignant transformation rates ranging from 0.2% up to 12.5%, these rates being up to 60 times higher as compared to the general population (13,16,17). The malignant transformation of OLP lesions has been attributed to both intrinsic (inflammation mediators) and extrinsic factors (18).…”

Section: Introductionmentioning

confidence: 99%

Oral lichen planus: a 4-year clinical follow-up study

Rimkevičius¹,

Aleksejūnienė²,

Pūrienė³

et al. 2017

Turk J Med Sci

View full text Add to dashboard Cite

Background/aim: This study aimed to examine oral lichen planus (OLP) cases histopathologically and cytologically, describe different clinical aspects of OLP manifestations, and associate different OLP clinical forms with self-reported oral health and with local and systemic risk factors. Materials and methods:All patients with a referral diagnosis of OLP received biopsies. The histological evaluation assessed infiltration with lymphocytes, epithelial hyperplasia, and hyperkeratosis. Histology was used to validate the OLP diagnosis and to evaluate the malignant transformation of OLP lesions. Clinical manifestations of OLP and potential local oral environment-related risks were clinically assessed. Systemic risks were evaluated by a structured questionnaire.Results: A total of 133 patients with a histologically confirmed OLP diagnosis were followed. There were more females (N = 109) than males (N = 24) and the majority of patients were older than 50 years. The reticular form (45.1%) was the most prevalent clinical form followed by the erosive-ulcerative form (33.8%). The histological characteristics were most pronounced in the erosive-ulcerative form. Of the OLP cases, 2.3% had a malignant transformation. Conclusion:Reticular and erosive-ulcerative were the most prevalent OLP forms. There were more female than male OLP patients. Except for medication use, there were no statistically significant differences among different clinical OLP forms in either local or systemic risk factor distributions.

show abstract

“…Whether OLP has a premalignant potential is a matter of discussion. The reported transformation incidence to oral cancer changes from 0-9% (14). For this reason, a clinical follow-up of patients with OLP, including repeated biopsies of recurrent or recalcitrant lesions is recommendable for any treatment (12,15).…”

Section: Discussionmentioning

confidence: 99%

The Effectiveness of Topical Pimecrolimus in the Treatment of Oral Lichen Planus

Mülayim¹,

Öztürk²,

Uzun³

2016

tdd

View full text Add to dashboard Cite

Objectives: Oral lichen planus (OLP) is a chronic inflammatory disorder of unknown etiology that affects the skin and the mucosa, especially the oral mucosa. Several therapeutic agents have been investigated for the treatment of OLP. All agents used in the OLP therapy are palliative. Potent topical steroids are used as the conventional therapy for OLP. Since side-effects or steroid resistance may be encountered, alternative treatments may be necessary. This study aimed to evaluate the efficacy and safety of the topical pimecrolimus in the treatment of OLP. Methods: Seventeen patients with OLP were recruited into this study. Topical pimecrolimus 1% cream was applied twice a day to the affected areas. Patients were followed up for 3-6 months. Photographs of the lesions were taken and analyzed for areas of ulceration, erythema, and reticulation in every clinical examination. Results: We found that topical pimecrolimus 1% cream was an effective treatment for OLP. Two patients could not complete the treatment protocol because of the side effects such as local irritation and nausea. Conclusion: Topical pimecrolimus may be a valuable second treatment choice for patients with steroid-related side-effects or steroid-resistant OLP. However further randomized controlled studies have to be conducted to compare conventional treatment of topical corticosteroid with topical pimecrolimus. Keywords: Oral lichen planus, pimecrolimus, calcineurin inhibitor, treatment, efficacy, safety Öz Abstract Amaç: Oral liken planus (OLP) deri ve mukozaları özellikle de oral mukozayı tutan, etiyolojisi bilinmeyen kronik enflamatuvar bir hastalıktır. OLP tedavisi için birkaç terapötik ajan araştırılmıştır. OLP'nin tedavisinde kullanılan bütün ajanlar palyatif etkilidir. OLP'nin geleneksel tedavisinde potent topikal steroidler kullanılır. Steroidlerin yan etkileri veya steroide direnç ile karşılaşılabileceğinden alternatif tedaviler gerekli olabilir. Bu çalışmada topikal pimekrolimusun OLP'nin tedavisindeki etkinliğini ve güvenirliğini değerlendirmek amaçlandı. Yöntemler: OLP'li 17 hasta çalışmaya alındı. Topikal pimekrolimus %1 krem etkilenmiş bölgelere günde 2 kez uygulandı. Hastalar 3-6 ay süreyle aylık olarak takip edildi. Her kontrolde lezyonların fotoğrafı çekilerek ülserasyon, eritem ve ağ yapısı gibi özellikleri değerlendirildi. Bulgular: Biz OLP'nin tedavisinde topikal %1 pimekrolimusu etkili bulduk. Çalışmaya alınan iki hasta bulantı hissi ve lokal irritasyon gibi yan etkiler nedeni ile tedavi protokolünü tamamlayamadı. Sonuç: Topikal pimekrolimus, steroid ile ilişkili yan etkileri olan hastalarda veya steroide dirençli OLP'nin tedavisinde ikinci seçenek olarak düşünülebilir. Ancak etkinliği tam olarak değerlendirebilmek için OLP'nin geleneksel tedavisi olan topikal steroid ile topikal pimekrolimusun karşılaştırmalı, randomize, kontrollü çalışmaları yapılmalıdır.

show abstract

Oral Lichen Planus and Malignant Transformation: Is a Recall of Patients Justified?

Cited by 142 publications

References 69 publications

Comparative Study of the Efficacy of Lycopene Versus Prednisolone in the Management of Oral Lichen Planus- A Randomized, Double Blind Clinical Trial.

Comparative Study of the Efficacy of Lycopene Versus Prednisolone in the Management of Oral Lichen Planus- A Randomized, Double Blind Clinical Trial.

Oral lichen planus: a 4-year clinical follow-up study

The Effectiveness of Topical Pimecrolimus in the Treatment of Oral Lichen Planus

Contact Info

Product

Resources

About