O<sub>2</sub>-Aufnahme und Kreislaufverhalten während Narkosen mit EEG-gesteuerter Anästhetikadosierung

Hausmann, D.; Schwilden, H.; Nadstawek, J.; Krajewski, W.

doi:10.1055/s-2007-1001075

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“…Hypothermia in patients during anesthesia has been shown to decrease the metabolic rate but does not change DO 2 . According to Hausmann et al (30), oxygen consumption during general anesthesia did not de-pend on the type of anesthetic administered. Abad Gurumeta and Lopez Quesada (31) showed that during prolonged anesthesia, an increase in the need for O 2 could have an adverse effect on hemodynamics.…”

Section: Discussionmentioning

confidence: 98%

Influence of Anesthetics on Cardiac Index and Metabolic Outcomes in Mitral and Aortic Valve Replacement in Adults: A Randomized Clinical Study

Baiterek¹,

Mustafin²

2023

Anesth Pain Med

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Background: Cardiac index (CI) and metabolic response to surgery are important indicators of the course of the intraoperative period. Objectives: This study aimed to determine the effect of sevoflurane, isoflurane, and propofol on CI and metabolic outcomes during aortic and mitral valve replacement in adults. Methods: In this single-center prospective randomized controlled clinical study, a total of 75 patients were randomly assigned into 3 groups according to the type of anesthesia: the propofol group (n = 25), the sevoflurane group (n = 25), and the isoflurane group (n = 25). Cardiac stroke volume (SV) was determined by intraesophageal echocardiography (SV = end-diastolic volume – end-systolic volume). Cardiac output (CO) and CI were calculated according to the formulas. Oxygen consumption during surgery = CI × arteriovenous difference. Indirect calorimetry was used to determine energy expenditure during anesthesia using a spirometry device. Results: The use of anesthetics did not change CI. Cardiac index decreased from 3 to 2.9 L/min/m2 in the propofol group, increased from 3.1 to 3.2 L/min/m2 in the sevoflurane group, and decreased from 2.9 to 2.7 L/min/m2 in the isoflurane group. Compared to inhaled anesthetics, propofol significantly reduced VO2 from 179.1 to 135.7 mL/min/m2. Propofol reduced energy expenditure from 1483.7 to 1333.5 kcal. Conclusions: Volatile anesthetics, propofol has practically no effect on CI in an uncomplicated surgery. Anesthesia with propofol is associated with lower VO2 and better oxygen delivery to tissues. Energy consumption during propofol anesthesia decreases.

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Section: Discussionmentioning

confidence: 98%

Influence of Anesthetics on Cardiac Index and Metabolic Outcomes in Mitral and Aortic Valve Replacement in Adults: A Randomized Clinical Study

Baiterek¹,

Mustafin²

2023

Anesth Pain Med

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O₂-Aufnahme und Kreislaufverhalten während Narkosen mit EEG-gesteuerter Anästhetikadosierung

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Influence of Anesthetics on Cardiac Index and Metabolic Outcomes in Mitral and Aortic Valve Replacement in Adults: A Randomized Clinical Study

Influence of Anesthetics on Cardiac Index and Metabolic Outcomes in Mitral and Aortic Valve Replacement in Adults: A Randomized Clinical Study

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O2-Aufnahme und Kreislaufverhalten während Narkosen mit EEG-gesteuerter Anästhetikadosierung

Cited by 1 publication

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Influence of Anesthetics on Cardiac Index and Metabolic Outcomes in Mitral and Aortic Valve Replacement in Adults: A Randomized Clinical Study

Influence of Anesthetics on Cardiac Index and Metabolic Outcomes in Mitral and Aortic Valve Replacement in Adults: A Randomized Clinical Study

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O₂-Aufnahme und Kreislaufverhalten während Narkosen mit EEG-gesteuerter Anästhetikadosierung