O tratamento das cicatrizes de esternotomia mediana com injeções de
                        triancinolona, placas de silicone e terapia combinada: um estudo prospectivo
                        randomizado

Oliveira, Gisele Viana de; Alvarenga, Lara Rodrigues de Morais Gambogi; Stuhr, Petra Maria de Oliveira Duarte; Cantaruti, Thiago A.; Ferreira, Álida Rosária Silva; Kitten, Gregory T.

doi:10.5935/scd1984-8773.202012104

Cited by 2 publications

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The tool will undergo routine calibration. Tissue tonometry is a simple, repeatable, and objective method of measuring tissue density and is clinically useful for assessing individual scar tissue [ 70 – 72 ].…”

Section: Data Collection and Managementmentioning

confidence: 99%

A randomised clinical trial study assessing the efficacy of 5% losartan potassium loaded in ethosomal gel to treat human keloids: a trial protocol

Anggraini,

Trisnowati,

Martien

et al. 2024

Trials

View full text Add to dashboard Cite

Background Keloid is a skin disorder that results from excessive fibrous tissue growth in the area of the initial trauma. Treating keloids can be challenging since the success of various treatments varies from one study to another. Triamcinolone acetonide injection, a standard treatment, can cause undesirable side effects. Meanwhile, the effectiveness of existing topical therapies for keloids is not always reliable. The pro-inflammatory, pro-proliferative, and pro-fibrotic effects of angiotensin II in human skin contribute to keloid formation. Losartan potassium, an angiotensin II blocker, has the potential to act as an anti-keloid agent. Due to the thicker skin structure of a keloid and ease of application, ethosome gel is chosen as a safe and comfortable carrier for losartan potassium, making it a good choice for treating keloids. Methods In this randomised clinical trial, 46 adults with keloids were divided into two treatment groups. One group of 23 participants received 5% losartan potassium loaded in ethosomal gel, while the other group of 23 participants received intralesional injections of 10% triamcinolone acetonide. Over 12 weeks, changes in POSAS 3.0 scores, degree of erythema and pigmentation, surface area, thickness, and pliability of the keloids will be measured at four different times: baseline, 4 weeks, 8 weeks, and 12 weeks. Statistical analysis will be conducted using SPSS software version 24, with a significance level of p < 0.05. Discussion Losartan potassium is believed to be beneficial for keloid management because it inhibits the angiotensin II receptor, which plays a role in inflammation, proliferation, and fibrosis. This study examines the efficacy of 5% losartan potassium loaded in ethosomal gel for human keloids. Trial registration Clinicaltrial.gov identifier NCT05893108. Registered on 7 June 2023.

show abstract

Section: Data Collection and Managementmentioning

confidence: 99%

A randomised clinical trial study assessing the efficacy of 5% losartan potassium loaded in ethosomal gel to treat human keloids: a trial protocol

Anggraini,

Trisnowati,

Martien

et al. 2024

Trials

View full text Add to dashboard Cite

show abstract

“…The tool will undergo routine calibration. Tissue tonometry is a simple, repeatable and objective method of measuring tissue density and is clinically useful for assessing individual scar tissue (68)(69)(70).…”

Section: Plans For Assessment and Collection Of Outcomes {18a}mentioning

confidence: 99%

A randomised clinical trial study assessing the efficacy of 5% losartan potassium loaded in ethosomal gel based on POSAS 3.0 score, degree of erythema and pigmentation, surface area, thickness and pliability of human keloids: a study protocol

Anggraini,

Trisnowati,

Martien

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Keloid is a skin disorder that results from excessive fibrous tissue growth in the area of the initial trauma. Treating keloids can be challenging since the success of various treatments varies from one study to another. Triamcinolone acetonide injection, a standard treatment, can cause undesirable side effects. Meanwhile, the effectiveness of existing topical therapies for keloids is not always reliable. The pro-inflammatory, pro-proliferative, and pro-fibrotic effects of angiotensin II in human skin contribute to keloid formation. Losartan potassium, an angiotensin II blocker, has the potential to act as an anti-keloid agent. Due to the thicker skin structure of a keloid and ease of application, ethosome gel is chosen as a safe and comfortable carrier for losartan potassium, making it a good choice for treating keloids. Methods: In this randomised clinical trial, 46 adults with keloids were divided into two treatment groups. One group of 23 participants received 5% losartan potassium loaded in ethosomal gel, while the other group of 23 participants received intralesional injections of 10% triamcinolone acetonide. Over 12 weeks, changes in POSAS 3.0 scores, erythema and pigmentation, surface area, thickness, and pliability of the keloids will be measured at four different times: baseline, four weeks, eight weeks, and twelve weeks. Statistical analysis will be conducted using SPSS software version 24, with a significance level of p<0.05. Discussion: Losartan potassium is believed to be beneficial for keloid management because it inhibits the angiotensin II receptor, which plays a role in inflammation, proliferation, and fibrosis. This study aims to examine the efficacy of 5% losartan potassium loaded in ethosomal gel for human keloids. Trial registration: Clinicaltrial.gov identifier NCT05893108. Registered on 7 June 2023.

show abstract

O tratamento das cicatrizes de esternotomia mediana com injeções de triancinolona, placas de silicone e terapia combinada: um estudo prospectivo randomizado

Cited by 2 publications

References 26 publications

A randomised clinical trial study assessing the efficacy of 5% losartan potassium loaded in ethosomal gel to treat human keloids: a trial protocol

A randomised clinical trial study assessing the efficacy of 5% losartan potassium loaded in ethosomal gel to treat human keloids: a trial protocol

A randomised clinical trial study assessing the efficacy of 5% losartan potassium loaded in ethosomal gel based on POSAS 3.0 score, degree of erythema and pigmentation, surface area, thickness and pliability of human keloids: a study protocol

Contact Info

Product

Resources

About