OBJECTIVE: To evaluate the prevalence and the clinical characteristics of wheezing in
infants aged 12 to 15 months in the city of Cuiabá, Mato Grosso State, Midwest
Brazil. METHODS: Parents and/or guardians of infants were interviewed and completed a written
standardized questionnaire of the Estudio Internacional de Sibilancia en Lactantes
(EISL) - phase 3 at primary healthcare clinics at the same day of children
vaccination or at home, from August of 2009 to November of 2010. RESULTS: 1,060 parents and/or guardians completed the questionnaire, and 514 (48.5%)
infants were male. Among the studied infants, 294 (27.7%) had at least one episode
of wheezing during the first year of life, beggining at 5.8±3.0 months of age,
with a predominance of male patients. The prevalence of occasional wheezing (<3
episodes of wheezing) was 15.0% and recurrent wheezing (≥3 episodes) was 12.7%.
Among the infants with recurrent wheezing, the use of inhaled β2-agonist, oral
corticosteroid, leukotriene receptor antagonist, as well as night symptoms,
respiratory distress, and hospitalization due to severe episodes were
significantly more frequent. Physician-diagnosed asthma was observed in 28 (9.5%)
of the wheezing infants. Among the wheezing infants, 80 (27.7%) were diagnosed
with pneumonia, of whom 33 (11.2%) required hospitalization; neverthless, no
differences between occasional and recurrent wheezing infants were found. CONCLUSIONS: The prevalence of recurrent wheezing and physician-diagnosed asthma in infants
were lower compared with those observed in other Brazilian studies. Recurrent
wheezing had early onset and high morbity.