O volume plaquetário médio está reduzido em adultos com lúpus ativo

Delgado‐García, Guillermo; Galarza‐Delgado, Dionicio Ángel; Colunga-Pedraza, I. J.; Borjas-Almaguer, Omar D.; Mandujano‐Cruz, Ilse; Benavides-Salgado, D.E.; Martínez‐Granados, Rolando Jacob; Atilano‐Díaz, Alexandro

doi:10.1016/j.rbr.2015.12.003

Cited by 12 publications

(7 citation statements)

References 17 publications

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“…Other studies have found results similar to ours [ 13 , 15 , 19 ]. In rheumatoid arthritis, there is a study that also demonstrated diminished results of MPV in the active disease.…”

Section: Discussionsupporting

confidence: 92%

“…MPV has been considered a possible marker of platelet activation and inflammatory process [ 13 ]. The pathophysiology of SLE involves the presence of inflammatory cytokines and deregulation of the complement system, which interferes with the activation of platelets [ 15 ]. A probable mechanism that may explain the relationship between reduced MPV and disease activity is the consumption of large platelets at sites of inflammation [ 6 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…This index has been shown to be associated with the inflammatory process, and it is also an important marker of platelet activation and function [ 5 , 6 , 13 - 18 ]. Several studies suggest that MPV may be a good marker of disease activity in SLE, presenting low cost and wide availability [ 5 , 13 , 15 , 19 ]. Recent studies have found that MPV significantly reduced in patients with active disease [ 15 , 19 ], including negative correlation with SLEDAI [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

“…Several studies suggest that MPV may be a good marker of disease activity in SLE, presenting low cost and wide availability [ 5 , 13 , 15 , 19 ]. Recent studies have found that MPV significantly reduced in patients with active disease [ 15 , 19 ], including negative correlation with SLEDAI [ 19 ]. Other study performed in a juvenile SLE (JSLE) population, however, showed significantly higher MPV values in patients compared to healthy controls and in the active disease group when compared to the remission group.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Mean Platelet Volume in Patients with Systemic Lupus Erythematosus

Hartmann¹,

Alegretti²,

Machado³

et al. 2018

TORJ

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Introduction:The Mean Platelet Volume (MPV) is a platelet activation biomarker that has been recently correlated with disease activity in SLE. We aimed to evaluate the MPV in patients with SLE comparing it with healthy individuals, to study the correlation between MPV and SLE Disease Activity Index (SLEDAI) in SLE patients and to analyze possible correlation between MPV and Erythrocyte Sedimentation Rate (ESR), C-Reactive Protein (CRP), and complement components C3 and C4.Methods:This is a cross-sectional study in which 81 patients with SLE according to the American College of Rheumatology (ACR) diagnostic classification criteria and 58 healthy controls were included. Active disease was defined as SLEDAI>0.Results:Patients with active SLE had decreased MPV when compared to inactive disease group (10.0±0.7fL vs. 10.7±1.0fL, p=0.005, respectively) and when compared to control group (10.9±1.0fL, p<0.001). Our study found a weak negative correlation between the SLEDAI and the MPV (r=-0.29, p=0.009). There was no correlation between MPV and CRP, ESR, C3 and C4. Also, no correlation between SLEDAI and CRP, ESR, C3 and C4 was found.Conclusion: MPV decreases in patients with active SLE and is inversely correlated with SLEDAI.

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“…Other studies have found results similar to ours [ 13 , 15 , 19 ]. In rheumatoid arthritis, there is a study that also demonstrated diminished results of MPV in the active disease.…”

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Assessment of Mean Platelet Volume in Patients with Systemic Lupus Erythematosus

Hartmann¹,

Alegretti²,

Machado³

et al. 2018

TORJ

View full text Add to dashboard Cite

show abstract

“…Perhaps the worst aspect of diabetes is the systemic inflammation and oxidative stress and they are almost accused of being the real reasons underlying many complications of diabetes [14] [15] [16]. MPV is now well known as a predictor of inflammation and has been shown in many cases as a marker of inflammation [17] [18] [19]. In our previous research, we have shown that we can use MPV in the diagnosis of uveitis and venous thrombosis in patients with Behçet's syndrome [20] [21].…”

Section: Introductionmentioning

confidence: 99%

Dipeptidyl Peptidase-4 Inhibitors and Inflammation: Dpp-4 Inhibitors Improve Mean Pleatelet Volume and Gamma Glutamyl Transferase Level

Avcı¹

2019

JBM

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AIM: The purpose of this research was to determine the changes of the inflammatory parameters in the long term with the use of dipeptidyl peptidase-4 inhibitors. Material and Methods: In this research we have retrospectively reviewed the records of 80 patients who had added dipeptidyl peptidase-4 inhibitors (40 sitagliptin and 40 vildagliptin) to their ongoing therapies. Patients' values of inflammation at the beginning of this process were taken as initial values, while values at the end of this process were considered as final values. Results: A total of 80 patients [38.8% (n = 31) of the patients were male, while 61.3% (n = 49) were female] enrolled in the study. When the whole group was evaluated, the mean age was 56.1 ± 9.7 years. The median follow-up time of the patients with DPP-4 inhibitors was 18 (2-64) months. The mean MPV value was measured as 8.79 ± 1.71 fL before DPP-4 inhibitors and it was 10.06 ± 1.42 fL after the follow-up period (p < 0.001). The median value serum GGT was 30.5 (13-194) U/L before DPP-4 inhibitor and 29.5 (12-112) U/L at the end (p = 0.048). The mean uric acid level before the use of dipeptidyl peptidase-4 inhibitors was 4.7 ± 1.6 mg/dL, and this level was 5.0 ± 1.5 mg/dL after the follow-up period (p = 0.048). Conclusion: In this study, it was observed that MPV and GGT levels were improved by dipeptidyl peptidase-4 inhibitors in long-term.

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From blood coagulation to innate and adaptive immunity: the role of platelets in the physiology and pathology of autoimmune disorders

2018

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Thrombosis and cardiovascular complications are common manifestations of a variety of pathological conditions, including infections and chronic inflammatory diseases. Hence, there is great interest in determining the hitherto unforeseen immune role of the main blood coagulation executor—the platelet. Platelets store and release a plethora of immunoactive molecules, generate microparticles, and interact with cells classically belonging to the immune system. The observed effects of platelet involvement in immune processes, especially in autoimmune diseases, are conflicting—from inciting inflammation to mediating its resolution. An in-depth understanding of the role of platelets in inflammation and immunity could open new therapeutic pathways for patients with autoimmune disorders. This review aims to summarize the current knowledge on the role of platelets in the patomechanisms of autoimmune disorders and suggests directions for future research.

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O volume plaquetário médio está reduzido em adultos com lúpus ativo

Abstract: In summary, MPV is decreased in adult patients with active lupus disease, and positively correlated with albumin, another biomarker of disease activity. Prospective studies are needed to evaluate the prognostic value of this biomarker.

Cited by 12 publications

References 17 publications

Assessment of Mean Platelet Volume in Patients with Systemic Lupus Erythematosus

Assessment of Mean Platelet Volume in Patients with Systemic Lupus Erythematosus

Dipeptidyl Peptidase-4 Inhibitors and Inflammation: Dpp-4 Inhibitors Improve Mean Pleatelet Volume and Gamma Glutamyl Transferase Level

From blood coagulation to innate and adaptive immunity: the role of platelets in the physiology and pathology of autoimmune disorders

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